SIGLEC5: Difference between revisions

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{{Infobox_gene}}
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'''Sialic acid-binding Ig-like lectin 5''' is a [[protein]] that in humans is encoded by the ''SIGLEC5'' [[gene]].<ref name="pmid10343116">{{cite journal | author = Kim HS | title = Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 84 | issue = 1–2 | pages = 96 |date=Jun 1999 | pmid = 10343116 | pmc =  | doi =10.1159/000015227 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8778| accessdate = }}</ref> SIGLEC5 has also been designated '''CD170''' ([[cluster of differentiation]] 170).
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Sialic acid binding Ig-like lectin 5
| HGNCid = 10874
| Symbol = SIGLEC5
| AltSymbols =; CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5
| OMIM = 604200
| ECnumber = 
| Homologene = 55783
| MGIid = 
| GeneAtlas_image1 = PBB_GE_SIGLEC5_220000_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8778
    | Hs_Ensembl = ENSG00000105501
    | Hs_RefseqProtein = NP_003821
    | Hs_RefseqmRNA = NM_003830
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 56807156
    | Hs_GenLoc_end = 56825400
    | Hs_Uniprot = O15389
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA =   
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Sialic acid binding Ig-like lectin 5''', also known as '''SIGLEC5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8778| accessdate = }}</ref> SIGLEC5 has also been designated '''CD170''' ([[cluster of differentiation]] 170).
 


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Cornish AL, Freeman S, Forbes G, ''et al.'' |title=Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. |journal=Blood |volume=92 |issue= 6 |pages= 2123-32 |year= 1998 |pmid= 9731071 |doi=  }}
*{{cite journal   |vauthors=Cornish AL, Freeman S, Forbes G, etal |title=Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33 |journal=Blood |volume=92 |issue= 6 |pages= 2123–32 |year= 1998 |pmid= 9731071 |doi=  }}
*{{cite journal | author=Kim HS |title=Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 96 |year= 1999 |pmid= 10343116 |doi=  }}
*{{cite journal   |vauthors=Patel N, Brinkman-Van der Linden EC, Altmann SW, etal |title=OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22729–38 |year= 1999 |pmid= 10428856 |doi=10.1074/jbc.274.32.22729 }}
*{{cite journal  | author=Patel N, Brinkman-Van der Linden EC, Altmann SW, ''et al.'' |title=OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22729-38 |year= 1999 |pmid= 10428856 |doi=  }}
*{{cite journal  | vauthors=Yousef GM, Ordon MH, Foussias G, Diamandis EP |title=Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes |journal=Gene |volume=286 |issue= 2 |pages= 259–70 |year= 2002 |pmid= 11943481 |doi=10.1016/S0378-1119(02)00432-8 }}
*{{cite journal  | author=Yousef GM, Ordon MH, Foussias G, Diamandis EP |title=Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. |journal=Gene |volume=286 |issue= 2 |pages= 259-70 |year= 2002 |pmid= 11943481 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Erickson-Miller CL, Freeman SD, Hopson CB, etal |title=Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes |journal=Exp. Hematol. |volume=31 |issue= 5 |pages= 382–8 |year= 2003 |pmid= 12763136 |doi=10.1016/S0301-472X(03)00046-8 }}
*{{cite journal | author=Erickson-Miller CL, Freeman SD, Hopson CB, ''et al.'' |title=Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. |journal=Exp. Hematol. |volume=31 |issue= 5 |pages= 382-8 |year= 2003 |pmid= 12763136 |doi=  }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Avril T, Freeman SD, Attrill H, etal |title=Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19843–51 |year= 2005 |pmid= 15769739 |doi= 10.1074/jbc.M502041200 }}
*{{cite journal | author=Avril T, Freeman SD, Attrill H, ''et al.'' |title=Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19843-51 |year= 2005 |pmid= 15769739 |doi= 10.1074/jbc.M502041200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rapoport EM, Pazynina GV, Sablina MA, etal |title=Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides |journal=Biochemistry Mosc. |volume=71 |issue= 5 |pages= 496–504 |year= 2006 |pmid= 16732727 |doi=10.1134/S0006297906050051 }}
*{{cite journal | author=Rapoport EM, Pazynina GV, Sablina MA, ''et al.'' |title=Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides. |journal=Biochemistry Mosc. |volume=71 |issue= 5 |pages= 496-504 |year= 2006 |pmid= 16732727 |doi=  }}
*{{cite journal  | vauthors=Biedermann B, Gil D, Bowen DT, Crocker PR |title=Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors |journal=Leuk. Res. |volume=31 |issue= 2 |pages= 211–20 |year= 2007 |pmid= 16828866 |doi= 10.1016/j.leukres.2006.05.026 }}
*{{cite journal  | author=Biedermann B, Gil D, Bowen DT, Crocker PR |title=Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors. |journal=Leuk. Res. |volume=31 |issue= 2 |pages= 211-20 |year= 2007 |pmid= 16828866 |doi= 10.1016/j.leukres.2006.05.026 }}
*{{cite journal   |vauthors=Angata T, Hayakawa T, Yamanaka M, etal |title=Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates |journal=FASEB J. |volume=20 |issue= 12 |pages= 1964–73 |year= 2006 |pmid= 17012248 |doi= 10.1096/fj.06-5800com }}
*{{cite journal | author=Angata T, Hayakawa T, Yamanaka M, ''et al.'' |title=Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. |journal=FASEB J. |volume=20 |issue= 12 |pages= 1964-73 |year= 2006 |pmid= 17012248 |doi= 10.1096/fj.06-5800com }}
*{{cite journal  | vauthors=Zhuravleva MA, Trandem K, Sun PD |title=STRUCTURAL IMPLICATIONS OF SIGLEC-5 MEDIATED SIALO-GLYCAN RECOGNITION |journal=J. Mol. Biol. |volume=375 |issue= 2 |pages= 437–47 |year= 2007 |pmid= 18022638 |doi= 10.1016/j.jmb.2007.10.009 | pmc=2245879 }}
*{{cite journal  | author=Zhuravleva MA, Trandem K, Sun PD |title=Structural implications of Siglec-5-mediated sialoglycan recognition. |journal=J. Mol. Biol. |volume=375 |issue= 2 |pages= 437-47 |year= 2007 |pmid= 18022638 |doi= 10.1016/j.jmb.2007.10.009 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Revision as of 06:21, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene.[1][2] SIGLEC5 has also been designated CD170 (cluster of differentiation 170).


References

  1. ↑ Kim HS (Jun 1999). "Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1–2): 96. doi:10.1159/000015227. PMID 10343116.
  2. ↑ "Entrez Gene: SIGLEC5 sialic acid binding Ig-like lectin 5".

Further reading


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