NCR3: Difference between revisions

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{{Infobox_gene}}
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'''Natural cytotoxicity triggering receptor 3''' is a [[protein]] that in humans is encoded by the ''NCR3'' [[gene]].<ref name="pmid8824804">{{cite journal | vauthors = Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM | title = Genes in a 220-kb region spanning the TNF cluster in human MHC | journal = Genomics | volume = 31 | issue = 2 | pages = 215–22 |date=Mar 1997 | pmid = 8824804 | pmc = | doi = 10.1006/geno.1996.0034 }}</ref><ref name="pmid11782277">{{cite journal | vauthors = Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga K, Yabe T | title = Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells | journal = Tissue Antigens | volume = 58 | issue = 4 | pages = 255–8 |date=Jan 2002 | pmid = 11782277 | pmc =  | doi =10.1034/j.1399-0039.2001.580406.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCR3 natural cytotoxicity triggering receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=259197| accessdate = }}</ref> NCR3 has also been designated as '''CD337''' ([[cluster of differentiation]] 337) and as '''NKp30'''.
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| image = 
| image_source = 
| PDB =
| Name = Natural cytotoxicity triggering receptor 3
| HGNCid = 19077
| Symbol = NCR3
| AltSymbols =; 1C7; CD337; LY117; NKp30
| OMIM = 
| ECnumber = 
| Homologene = 51827
| MGIid = 
| GeneAtlas_image1 = PBB_GE_NCR3_211010_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCR3_210763_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCR3_211583_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 259197
    | Hs_Ensembl = ENSG00000204475
    | Hs_RefseqProtein = NP_667341
    | Hs_RefseqmRNA = NM_147130
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 31664639
    | Hs_GenLoc_end = 31668741
    | Hs_Uniprot = O14931
    | Mm_EntrezGene =   
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Natural cytotoxicity triggering receptor 3''', also known as '''NCR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NCR3 natural cytotoxicity triggering receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=259197| accessdate = }}</ref> NCR3 has also been designated as '''CD337''' ([[cluster of differentiation]] 337).


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Djeu JY, Jiang K, Wei S |title=A view to a kill: signals triggering cytotoxicity. |journal=Clin. Cancer Res. |volume=8 |issue= 3 |pages= 636-40 |year= 2002 |pmid= 11895890 |doi=  }}
*{{cite journal  | vauthors=Djeu JY, Jiang K, Wei S |title=A view to a kill: signals triggering cytotoxicity |journal=Clin. Cancer Res. |volume=8 |issue= 3 |pages= 636–40 |year= 2002 |pmid= 11895890 |doi=  }}
*{{cite journal | author=Holzinger I, de Baey A, Messer G, ''et al.'' |title=Cloning and genomic characterization of LST1: a new gene in the human TNF region. |journal=Immunogenetics |volume=42 |issue= 5 |pages= 315-22 |year= 1995 |pmid= 7590964 |doi=  }}
*{{cite journal   |vauthors=Holzinger I, de Baey A, Messer G, etal |title=Cloning and genomic characterization of LST1: a new gene in the human TNF region |journal=Immunogenetics |volume=42 |issue= 5 |pages= 315–22 |year= 1995 |pmid= 7590964 |doi=10.1007/BF00179392  }}
*{{cite journal  | author=Nalabolu SR, Shukla H, Nallur G, ''et al.'' |title=Genes in a 220-kb region spanning the TNF cluster in human MHC. |journal=Genomics |volume=31 |issue= 2 |pages= 215-22 |year= 1997 |pmid= 8824804 |doi= 10.1006/geno.1996.0034 }}
*{{cite journal   |vauthors=de Baey A, Fellerhoff B, Maier S, etal |title=Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing |journal=Genomics |volume=45 |issue= 3 |pages= 591–600 |year= 1998 |pmid= 9367684 |doi= 10.1006/geno.1997.4963 }}
*{{cite journal | author=de Baey A, Fellerhoff B, Maier S, ''et al.'' |title=Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing. |journal=Genomics |volume=45 |issue= 3 |pages= 591-600 |year= 1998 |pmid= 9367684 |doi= 10.1006/geno.1997.4963 }}
*{{cite journal  | vauthors=Neville MJ, Campbell RD |title=A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC |journal=J. Immunol. |volume=162 |issue= 8 |pages= 4745–54 |year= 1999 |pmid= 10202016 |doi=  }}
*{{cite journal  | author=Neville MJ, Campbell RD |title=A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC. |journal=J. Immunol. |volume=162 |issue= 8 |pages= 4745-54 |year= 1999 |pmid= 10202016 |doi=  }}
*{{cite journal   |vauthors=Pende D, Parolini S, Pessino A, etal |title=Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells |journal=J. Exp. Med. |volume=190 |issue= 10 |pages= 1505–16 |year= 1999 |pmid= 10562324 |doi=10.1084/jem.190.10.1505  | pmc=2195691 }}
*{{cite journal | author=Pende D, Parolini S, Pessino A, ''et al.'' |title=Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. |journal=J. Exp. Med. |volume=190 |issue= 10 |pages= 1505-16 |year= 1999 |pmid= 10562324 |doi=  }}
*{{cite journal   |vauthors=Sivakamasundari R, Raghunathan A, Zhang CY, etal |title=Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC |journal=Immunogenetics |volume=51 |issue= 8–9 |pages= 723–32 |year= 2000 |pmid= 10941844 |doi=10.1007/s002510000192 }}
*{{cite journal | author=Sivakamasundari R, Raghunathan A, Zhang CY, ''et al.'' |title=Expression and cellular localization of the protein encoded by the 1C7 gene: a recently described component of the MHC. |journal=Immunogenetics |volume=51 |issue= 8-9 |pages= 723-32 |year= 2000 |pmid= 10941844 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Sato M, Ohashi J, Tsuchiya N, ''et al.'' |title=Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. |journal=Tissue Antigens |volume=58 |issue= 4 |pages= 255-8 |year= 2002 |pmid= 11782277 |doi= }}
*{{cite journal   |vauthors=Le Bouteiller P, Barakonyi A, Giustiniani J, etal |title=Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16963–8 |year= 2003 |pmid= 12486241 |doi= 10.1073/pnas.012681099 | pmc=139252 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Augugliaro R, Parolini S, Castriconi R, etal |title=Selective cross-talk among natural cytotoxicity receptors in human natural killer cells |journal=Eur. J. Immunol. |volume=33 |issue= 5 |pages= 1235–41 |year= 2003 |pmid= 12731048 |doi= 10.1002/eji.200323896 }}
*{{cite journal | author=Le Bouteiller P, Barakonyi A, Giustiniani J, ''et al.'' |title=Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16963-8 |year= 2003 |pmid= 12486241 |doi= 10.1073/pnas.012681099 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Augugliaro R, Parolini S, Castriconi R, ''et al.'' |title=Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. |journal=Eur. J. Immunol. |volume=33 |issue= 5 |pages= 1235-41 |year= 2003 |pmid= 12731048 |doi= 10.1002/eji.200323896 }}
*{{cite journal   |vauthors=Marcenaro E, Augugliaro R, Falco M, etal |title=CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity |journal=Eur. J. Immunol. |volume=33 |issue= 12 |pages= 3367–76 |year= 2004 |pmid= 14635045 |doi= 10.1002/eji.200324425 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Xie T, Rowen L, Aguado B, etal |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 | pmc=403804 }}
*{{cite journal | author=Marcenaro E, Augugliaro R, Falco M, ''et al.'' |title=CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity. |journal=Eur. J. Immunol. |volume=33 |issue= 12 |pages= 3367-76 |year= 2004 |pmid= 14635045 |doi= 10.1002/eji.200324425 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal   |vauthors=Nowbakht P, Ionescu MC, Rohner A, etal |title=Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias |journal=Blood |volume=105 |issue= 9 |pages= 3615–22 |year= 2005 |pmid= 15657183 |doi= 10.1182/blood-2004-07-2585 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Poggi A, Massaro AM, Negrini S, etal |title=Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors |journal=J. Immunol. |volume=174 |issue= 5 |pages= 2653–60 |year= 2005 |pmid= 15728472 |doi=  10.4049/jimmunol.174.5.2653}}
*{{cite journal | author=Nowbakht P, Ionescu MC, Rohner A, ''et al.'' |title=Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. |journal=Blood |volume=105 |issue= 9 |pages= 3615-22 |year= 2005 |pmid= 15657183 |doi= 10.1182/blood-2004-07-2585 }}
*{{cite journal   |vauthors=Vitale M, Della Chiesa M, Carlomagno S, etal |title=NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor |journal=Blood |volume=106 |issue= 2 |pages= 566–71 |year= 2005 |pmid= 15784725 |doi= 10.1182/blood-2004-10-4035 }}
*{{cite journal | author=Poggi A, Massaro AM, Negrini S, ''et al.'' |title=Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. |journal=J. Immunol. |volume=174 |issue= 5 |pages= 2653-60 |year= 2005 |pmid= 15728472 |doi=  }}
*{{cite journal   |vauthors=Warren HS, Jones AL, Freeman C, etal |title=Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan |journal=J. Immunol. |volume=175 |issue= 1 |pages= 207–12 |year= 2005 |pmid= 15972650 |doi=  10.4049/jimmunol.175.1.207}}
*{{cite journal | author=Vitale M, Della Chiesa M, Carlomagno S, ''et al.'' |title=NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor. |journal=Blood |volume=106 |issue= 2 |pages= 566-71 |year= 2005 |pmid= 15784725 |doi= 10.1182/blood-2004-10-4035 }}
*{{cite journal  |vauthors=Joyce MG, Gordon M, Tran P, etal |title=Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site |journal=PNAS |volume=108| issue=15| pages=6223–6228| pmid=    21444796| year=2011 |doi=10.1073/pnas.1100622108 | pmc=3076882}}
*{{cite journal | author=Warren HS, Jones AL, Freeman C, ''et al.'' |title=Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. |journal=J. Immunol. |volume=175 |issue= 1 |pages= 207-12 |year= 2005 |pmid= 15972650 |doi=  }}
}}
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* {{MeshName|NCR3+protein,+human}}
* {{MeshName|NCR3+protein,+human}}


{{membrane-protein-stub}}
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{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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{{DEFAULTSORT:Ncr3}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Human proteins]]
 
 
{{membrane-protein-stub}}

Latest revision as of 12:42, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Natural cytotoxicity triggering receptor 3 is a protein that in humans is encoded by the NCR3 gene.[1][2][3] NCR3 has also been designated as CD337 (cluster of differentiation 337) and as NKp30.


References

  1. ↑ Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (Mar 1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics. 31 (2): 215–22. doi:10.1006/geno.1996.0034. PMID 8824804.
  2. ↑ Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga K, Yabe T (Jan 2002). "Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells". Tissue Antigens. 58 (4): 255–8. doi:10.1034/j.1399-0039.2001.580406.x. PMID 11782277.
  3. ↑ "Entrez Gene: NCR3 natural cytotoxicity triggering receptor 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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