SSH3: Difference between revisions
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'''Protein phosphatase Slingshot homolog 3''' is an [[enzyme]] that in humans is encoded by the ''SSH3'' [[gene]].<ref name="pmid11832213">{{cite journal | vauthors = Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T | title = Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin | journal = Cell | volume = 108 | issue = 2 | pages = 233–46 | date = January 2002 | pmid = 11832213 | pmc = | doi = 10.1016/S0092-8674(01)00638-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961| accessdate = }}</ref> | '''Protein phosphatase Slingshot homolog 3''' is an [[enzyme]] that in humans is encoded by the ''SSH3'' [[gene]].<ref name="pmid11832213">{{cite journal | vauthors = Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T | title = Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin | journal = Cell | volume = 108 | issue = 2 | pages = 233–46 | date = January 2002 | pmid = 11832213 | pmc = | doi = 10.1016/S0092-8674(01)00638-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961| accessdate = }}</ref> | ||
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== Function == | == Function == | ||
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961| accessdate = }}</ref> | The [[cofilin|ADF (actin-depolymerizing factor)/cofilin family]] (see MIM 601442) is composed of stimulus-responsive mediators of [[actin]] dynamics. ADF/cofilin [[proteins]] are inactivated by [[kinases]] such as LIM domain kinase-1 ([[LIMK1]]; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961| accessdate = }}</ref> | ||
== References == | == References == | ||
Latest revision as of 21:37, 20 February 2018
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Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.[1][2]
Function
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][2]
References
- ↑ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (January 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213.
- ↑ 2.0 2.1 "Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)".
Further reading
- Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC (November 2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". The Journal of Biological Chemistry. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O (February 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
- Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K (October 2003). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes to Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860.
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