P-selectin

selectin P (granule membrane protein 140kDa, antigen CD62)
Identifiers
Symbol	SELP
Alt. symbols	GRMP
Entrez	6403
HUGO	10721
OMIM	173610
RefSeq	NM_003005
UniProt	P16109
Other data
Locus	Chr. 1 q23-q25

P-selectin is a cell adhesion molecule (CAM) found in granules in endothelial cells (cells lining blood vessels) and activated platelets. Other names for P-selectin include CD62P, Granule Membrane Protein 140 (GMP-140), and Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM). It was first shown to be found in endothelial cells in 1989.

Function

P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by molecules such as histamine or thrombin during inflammation, P-selectin moves from an internal cell location to the endothelial cell surface.

Thrombin is one trigger which can stimualte endothelial-cell release of P-selectin and recent studies suggest an additional Ca2+-independent pathway involved in release of P-selectin.

Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase-resistant structures, clearly different than those reported for E-selectin, and suggest disparate roles for P-selectin and E-selectin during recruitment during inflammatory responses.

Location

Endothelial cells: stored in the membrane of Weibel-Palade bodies.

Platelets: stored in alpha-granules.

See also

• Selectin

External links

• P-Selectin at the US National Library of Medicine Medical Subject Headings (MeSH)