CD6
| CD6 molecule | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | CD6 ; TP120 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4893 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[1]
See also
References
Further reading
- Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins". J. Exp. Med. 174 (4): 949–52. PMID 1919444.
- Swack JA, Mier JW, Romain PL; et al. (1991). "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137–43. PMID 2016320.
- Tsuge I, Utsumi KR, Ueda R; et al. (1985). "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11". Somat. Cell Mol. Genet. 11 (3): 217–22. PMID 3923629.
- Whitney GS, Starling GC, Bowen MA; et al. (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site". J. Biol. Chem. 270 (31): 18187–90. PMID 7543097.
- Robinson WH, Neuman de Vegvar HE, Prohaska SS; et al. (1995). "Human CD6 possesses a large, alternatively spliced cytoplasmic domain". Eur. J. Immunol. 25 (10): 2765–9. PMID 7589069.
- Wee S, Schieven GL, Kirihara JM; et al. (1993). "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219–23. PMID 7678115.
- Bowen MA, Whitney GS, Neubauer M; et al. (1997). "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms". J. Immunol. 158 (3): 1149–56. PMID 9013954.
- Kobarg J, Whitney GS, Palmer D; et al. (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol. 27 (11): 2971–80. PMID 9394826.
- Singer NG, Mitra R, Lialios F; et al. (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett. 58 (1): 9–14. PMID 9436462.
- Gimferrer I, Farnós M, Calvo M; et al. (2003). "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564–71. doi:10.1074/jbc.M209591200. PMID 12473675.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Shin BK, Wang H, Yim AM; et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
- Gimferrer I, Ibáñez A, Farnós M; et al. (2005). "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains". J. Immunol. 175 (3): 1406–14. PMID 16034076.
- Kato Y, Tanaka Y, Hayashi M; et al. (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. Immunol. 177 (2): 877–84. PMID 16818742.
- Ibáñez A, Sarrias MR, Farnós M; et al. (2006). "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor". J. Immunol. 177 (2): 1152–9. PMID 16818773.
- Hassan NJ, Simmonds SJ, Clarkson NG; et al. (2006). "CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76". Mol. Cell. Biol. 26 (17): 6727–38. doi:10.1128/MCB.00688-06. PMID 16914752.
- Castro MA, Oliveira MI, Nunes RJ; et al. (2007). "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse". J. Immunol. 178 (7): 4351–61. PMID 17371992.
- Sarrias MR, Farnós M, Mota R; et al. (2007). "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11724–9. doi:10.1073/pnas.0702815104. PMID 17601777.
External links
- CD6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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