CD9
| CD9 molecule | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CD9 ; 5H9; BA2; BTCC-1; DRAP-27; GIG2; MIC3; MRP-1; P24; TSPAN29 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 20420 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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CD9 molecule, also known as CD9, is a human gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration and also trigger platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.[1]
See also
References
Further reading
- Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Lett. 288 (1–2): 1–4. PMID 1879540.
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Ninomiya H, Sims PJ (1992). "The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9". J. Biol. Chem. 267 (19): 13675–80. PMID 1377690.
- Miyake M, Koyama M, Seno M, Ikeyama S (1992). "Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility". J. Exp. Med. 174 (6): 1347–54. PMID 1720807.
- Boucheix C, Benoit P, Frachet P; et al. (1991). "Molecular cloning of the CD9 antigen. A new family of cell surface proteins". J. Biol. Chem. 266 (1): 117–22. PMID 1840589.
- Iwamoto R, Senoh H, Okada Y; et al. (1991). "An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor". J. Biol. Chem. 266 (30): 20463–9. PMID 1939101.
- Benoit P, Gross MS, Frachet P; et al. (1991). "Assignment of the human CD9 gene to chromosome 12 (region P13) by use of human specific DNA probes". Hum. Genet. 86 (3): 268–72. PMID 1997380.
- Lanza F, Wolf D, Fox CF; et al. (1991). "cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins". J. Biol. Chem. 266 (16): 10638–45. PMID 2037603.
- Higashihara M, Takahata K, Yatomi Y; et al. (1990). "Purification and partial characterization of CD9 antigen of human platelets". FEBS Lett. 264 (2): 270–4. PMID 2358073.
- Katz F, Povey S, Parkar M; et al. (1984). "Chromosome assignment of monoclonal antibody-defined determinants on human leukemic cells". Eur. J. Immunol. 13 (12): 1008–13. PMID 6198179.
- Masellis-Smith A, Shaw AR (1994). "CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin". J. Immunol. 152 (6): 2768–77. PMID 7511626.
- Chalupny NJ, Kanner SB, Schieven GL; et al. (1993). "Tyrosine phosphorylation of CD19 in pre-B and mature B cells". EMBO J. 12 (7): 2691–6. PMID 7687539.
- Ikeyama S, Koyama M, Yamaoko M; et al. (1993). "Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA". J. Exp. Med. 177 (5): 1231–7. PMID 8478605.
- Rubinstein E, Benoit P, Billard M; et al. (1993). "Organization of the human CD9 gene". Genomics. 16 (1): 132–8. doi:10.1006/geno.1993.1150. PMID 8486348.
- Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochem. Biophys. Res. Commun. 222 (1): 13–8. doi:10.1006/bbrc.1996.0690. PMID 8630057.
- Schmidt C, Künemund V, Wintergerst ES; et al. (1996). "CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1". J. Neurosci. Res. 43 (1): 12–31. doi:10.1002/jnr.490430103. PMID 8838570.
- Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem. 45 (4): 515–25. PMID 9111230.
- Rubinstein E, Poindessous-Jazat V, Le Naour F; et al. (1997). "CD9, but not other tetraspans, associates with the beta1 integrin precursor". Eur. J. Immunol. 27 (8): 1919–27. PMID 9295027.
- Tachibana I, Bodorova J, Berditchevski F; et al. (1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46): 29181–9. PMID 9360996.
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