LAG3

Lymphocyte-activation gene 3
Identifiers
Symbols	LAG3 ; CD223
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1719
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LAG3 206486 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Lymphocyte-activation gene 3, also known as LAG3, is a human gene. LAG3 has also recently been designated CD223 (cluster of differentiation 223).

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.

Further reading

• Triebel F (2004). "LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination". Trends Immunol. 24 (12): 619–22. PMID 14644131.
• Baixeras E, Huard B, Miossec C; et al. (1992). "Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens". J. Exp. Med. 176 (2): 327–37. PMID 1380059.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Triebel F, Jitsukawa S, Baixeras E; et al. (1990). "LAG-3, a novel lymphocyte activation gene closely related to CD4". J. Exp. Med. 171 (5): 1393–405. PMID 1692078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Blum MD, Wong GT, Higgins KM; et al. (1993). "Reconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancer". J. Exp. Med. 177 (5): 1343–58. PMID 8097522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huard B, Mastrangeli R, Prigent P; et al. (1997). "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5744–9. PMID 9159144.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bruniquel D, Borie N, Triebel F (1998). "Genomic organization of the human LAG-3/CD4 locus". Immunogenetics. 47 (1): 96–8. PMID 9382927.CS1 maint: Multiple names: authors list (link)
• Bruniquel D, Borie N, Hannier S, Triebel F (1998). "Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II". Immunogenetics. 48 (2): 116–24. PMID 9634475.CS1 maint: Multiple names: authors list (link)
• Hannier S, Tournier M, Bismuth G, Triebel F (1998). "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling". J. Immunol. 161 (8): 4058–65. PMID 9780176.CS1 maint: Multiple names: authors list (link)
• Hannier S, Triebel F (1999). "The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes". Int. Immunol. 11 (11): 1745–52. PMID 10545478.
• Iouzalen N, Andreae S, Hannier S, Triebel F (2001). "LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that binds to a repeated EP motif in the intracellular region of LAG-3, may participate in the down-regulation of the CD3/TCR activation pathway". Eur. J. Immunol. 31 (10): 2885–91. PMID 11592063.CS1 maint: Multiple names: authors list (link)
• Andreae S, Piras F, Burdin N, Triebel F (2002). "Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223)". J. Immunol. 168 (8): 3874–80. PMID 11937541.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andreae S, Buisson S, Triebel F (2003). "MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223)". Blood. 102 (6): 2130–7. doi:10.1182/blood-2003-01-0273. PMID 12775570.CS1 maint: Multiple names: authors list (link)
• Cai XF, Tao Z, Yan ZQ; et al. (2004). "Molecular cloning, characterisation and tissue-specific expression of human LAG3, a member of the novel Lag1 protein family". DNA Seq. 14 (2): 79–86. PMID 12825348.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gandhi MK, Lambley E, Duraiswamy J; et al. (2006). "Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients". Blood. 108 (7): 2280–9. doi:10.1182/blood-2006-04-015164. PMID 16757686.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lundmark F, Harbo HF, Celius EG; et al. (2007). "Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations". J. Neuroimmunol. 180 (1–2): 193–8. doi:10.1016/j.jneuroim.2006.08.009. PMID 17020785.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• LAG3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.