ICAM-1
| intercellular adhesion molecule 1 (CD54) | |
|---|---|
| Identifiers | |
| Symbol | ICAM1 |
| Entrez | 3383 |
| HUGO | 5344 |
| OMIM | 147840 |
| RefSeq | NM_000201 |
| UniProt | P05362 |
| Other data | |
| Locus | Chr. 19 p13.3-13.2 |
Overview
ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages and lymphocytes.
ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.[1] [2] While ICAM-1 has not been shown to be directly correlated with cerebral vasospasm, a secondary insult which affects 70% of SAH patients, treatment with anti-ICAM-1 reduced the severity of vasospasm.
References
- ↑ Polin RS, Bavbek M, Shaffrey ME, Billups K, Bogaev CA, Kassell NF, Lee KS: Detection of soluble E-selectin, ICAM-1, VCAM-1 and L-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage. Journal of Neurosurgery 89:559-567,1998.Template:Entrez Pubmed
- ↑ Frijns CJM, Kappelle LJ: Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease. Stroke 33:2115-2122,2002. Template:Entrez Pubmed
External links
- Intercellular+Adhesion+Molecule-1 at the US National Library of Medicine Medical Subject Headings (MeSH)