LAIR1
| Leukocyte-associated immunoglobulin-like receptor 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | LAIR1 ; CD305; LAIR-1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 48097 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE LAIR1 210644 s at tn.png | |||||||||||
| File:PBB GE LAIR1 208071 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Leukocyte-associated immunoglobulin-like receptor 1, also known as LAIR1, is a human gene.[1] LAIR1 has also been designated as CD305 (cluster of differentiation 305).
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[1]
References
Further reading
- Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. PMID 10404045.
- Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells". Curr. Top. Microbiol. Immunol. 244: 151–7. PMID 10453657.
- Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents. 17 (4): 330–3. PMID 15065762.
- Meyaard L, Adema GJ, Chang C; et al. (1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. PMID 9285412.
- Poggi A, Tomasello E, Ferrero E; et al. (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. PMID 9692876.
- Meyaard L, Hurenkamp J, Clevers H; et al. (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. PMID 10229813.
- van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". Eur. J. Immunol. 29 (10): 3160–7. PMID 10540327.
- Xu M, Zhao R, Zhao ZJ (2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762.
- Poggi A, Pellegatta F, Leone BE; et al. (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. PMID 11069054.
- Sathish JG, Johnson KG, Fuller KJ; et al. (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. PMID 11160222.
- Meyaard L, van der Vuurst de Vries AR, de Ruiter T; et al. (2001). "The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR)". J. Exp. Med. 194 (1): 107–12. PMID 11435477.
- Saverino D, Fabbi M, Merlo A; et al. (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. PMID 12072189.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Aoukaty A, Lee IF, Wu J, Tan R (2004). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. PMID 12757266.
- Verbrugge A, Ruiter Td T, Clevers H, Meyaard L (2004). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. PMID 14565933.
- De Milito A, Nilsson A, Titanji K; et al. (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood. 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
External links
- LAIR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.