Colony stimulating factor 1 receptor
| Colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | |||||||||||
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| Symbols | CSF1R ; C-FMS; CD115; CSFR; FIM2; FMS | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3817 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Colony stimulating factor 1 receptor (CSF1R) also known as CD115 (Cluster of Differentiation 115), is a human gene.[1]
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates this receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.[1]
See also
References
Further reading
- Rettenmier CW, Roussel MF, Sherr CJ (1989). "The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand". J. Cell Sci. Suppl. 9: 27–44. PMID 2978516.
- Stanley ER, Berg KL, Einstein DB; et al. (1997). "Biology and action of colony--stimulating factor-1". Mol. Reprod. Dev. 46 (1): 4–10. doi:10.1002/(SICI)1098-2795(199701)46:1<4::AID-MRD2>3.0.CO;2-V. PMID 8981357.
- Gout I, Dhand R, Panayotou G; et al. (1993). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system". Biochem. J. 288 ( Pt 2): 395–405. PMID 1334406.
- Galland F, Stefanova M, Lafage M, Birnbaum D (1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenet. Cell Genet. 60 (2): 114–6. PMID 1611909.
- Boultwood J, Rack K, Kelly S; et al. (1991). "Loss of both CSF1R (FMS) alleles in patients with myelodysplasia and a chromosome 5 deletion". Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6176–80. PMID 1829836.
- Roussel MF, Cleveland JL, Shurtleff SA, Sherr CJ (1991). "Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling". Nature. 353 (6342): 361–3. doi:10.1038/353361a0. PMID 1833648.
- Reedijk M, Liu XQ, Pawson T (1990). "Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor". Mol. Cell. Biol. 10 (11): 5601–8. PMID 2172781.
- Ridge SA, Worwood M, Oscier D; et al. (1990). "FMS mutations in myelodysplastic, leukemic, and normal subjects". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1377–80. PMID 2406720.
- Sherr CJ, Rettenmier CW, Sacca R; et al. (1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1". Cell. 41 (3): 665–76. PMID 2408759.
- Coussens L, Van Beveren C, Smith D; et al. (1986). "Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus". Nature. 320 (6059): 277–80. doi:10.1038/320277a0. PMID 2421165.
- Hampe A, Shamoon BM, Gobet M; et al. (1989). "Nucleotide sequence and structural organization of the human FMS proto-oncogene". Oncogene Res. 4 (1): 9–17. PMID 2524025.
- Visvader J, Verma IM (1989). "Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes". Mol. Cell. Biol. 9 (3): 1336–41. PMID 2524648.
- Roberts WM, Look AT, Roussel MF, Sherr CJ (1988). "Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes". Cell. 55 (4): 655–61. PMID 2846185.
- Xu DQ, Guilhot S, Galibert F (1985). "Restriction fragment length polymorphism of the human c-fms gene". Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2862–5. PMID 2986142.
- Sherr CJ, Rettenmier CW (1987). "The fms gene and the CSF-1 receptor". Cancer Surv. 5 (2): 221–32. PMID 3022923.
- Le Beau MM, Westbrook CA, Diaz MO; et al. (1986). "Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders". Science. 231 (4741): 984–7. PMID 3484837.
- Wheeler EF, Roussel MF, Hampe A; et al. (1986). "The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences". J. Virol. 59 (2): 224–33. PMID 3525854.
- Browning PJ, Bunn HF, Cline A; et al. (1986). ""Replacement" of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 7800–4. PMID 3532121.
- Verbeek JS, Roebroek AJ, van den Ouweland AM; et al. (1985). "Human c-fms proto-oncogene: comparative analysis with an abnormal allele". Mol. Cell. Biol. 5 (2): 422–6. PMID 3974576.
External links
- CSF1R+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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