MSR1

Macrophage scavenger receptor 1
Identifiers
Symbols	MSR1 ; CD204; SCARA1; SR-A; phSR1; phSR2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 12822
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MSR1 214770 at tn.png
File:PBB GE MSR1 208423 s at tn.png
File:PBB GE MSR1 211887 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Macrophage scavenger receptor 1, also known as MSR1, is a human gene.

MSR1 has also recently been designated CD204 (cluster of differentiation 204).

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.

Further reading

• Asaoka H, Matsumoto A, Itakura H, Kodama T (1993). "[Structural and function of the human macrophage scavenger receptor]". Nippon Rinsho. 51 (6): 1677–83. PMID 8391600.CS1 maint: Multiple names: authors list (link)
• Naito M, Suzuki H, Mori T; et al. (1992). "Coexpression of type I and type II human macrophage scavenger receptors in macrophages of various organs and foam cells in atherosclerotic lesions". Am. J. Pathol. 141 (3): 591–9. PMID 1519666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsumoto A, Naito M, Itakura H; et al. (1991). "Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions". Proc. Natl. Acad. Sci. U.S.A. 87 (23): 9133–7. PMID 2251254.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Emi M, Asaoka H, Matsumoto A; et al. (1993). "Structure, organization, and chromosomal mapping of the human macrophage scavenger receptor gene". J. Biol. Chem. 268 (3): 2120–5. PMID 8093617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ashkenas J, Penman M, Vasile E; et al. (1993). "Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors". J. Lipid Res. 34 (6): 983–1000. PMID 8394868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Resnick D, Chatterton JE, Schwartz K; et al. (1996). "Structures of class A macrophage scavenger receptors. Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain". J. Biol. Chem. 271 (43): 26924–30. PMID 8900177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu HY, Hajjar DP, Khan KM, Falcone DJ (1998). "Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway". J. Biol. Chem. 273 (2): 1240–6. PMID 9422792.CS1 maint: Multiple names: authors list (link)
• Gough PJ, Greaves DR, Gordon S (1998). "A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake". J. Lipid Res. 39 (3): 531–43. PMID 9548586.CS1 maint: Multiple names: authors list (link)
• Teupser D, Thiery J, Seidel D (1999). "Alpha-tocopherol down-regulates scavenger receptor activity in macrophages". Atherosclerosis. 144 (1): 109–15. PMID 10381284.CS1 maint: Multiple names: authors list (link)
• Nakamura T, Hinagata J, Tanaka T; et al. (2002). "HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors". Biochem. Biophys. Res. Commun. 290 (2): 858–64. doi:10.1006/bbrc.2001.6271. PMID 11785981.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tomokiyo R, Jinnouchi K, Honda M; et al. (2002). "Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors". Atherosclerosis. 161 (1): 123–32. PMID 11882324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu J, Zheng SL, Komiya A; et al. (2002). "Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk". Nat. Genet. 32 (2): 321–5. doi:10.1038/ng994. PMID 12244320.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu J, Zheng SL, Komiya A; et al. (2003). "Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk". Am. J. Hum. Genet. 72 (1): 208–12. PMID 12471593.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kosswig N, Rice S, Daugherty A, Post SR (2003). "Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains". J. Biol. Chem. 278 (36): 34219–25. doi:10.1074/jbc.M303465200. PMID 12819208.CS1 maint: Multiple names: authors list (link)
• Miller DC, Zheng SL, Dunn RL; et al. (2003). "Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men". Cancer Res. 63 (13): 3486–9. PMID 12839931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, McDonnell SK, Cunningham JM; et al. (2003). "No association of germline alteration of MSR1 with prostate cancer risk". Nat. Genet. 35 (2): 128–9. doi:10.1038/ng1239. PMID 12958598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nupponen NN, Wallén MJ, Ponciano D; et al. (2004). "Mutational analysis of susceptibility genes RNASEL/HPC1, ELAC2/HPC2, and MSR1 in sporadic prostate cancer". Genes Chromosomes Cancer. 39 (2): 119–25. doi:10.1002/gcc.10308. PMID 14695991.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.