The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[1]
Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID7832990.
Yoshida T, Imai T, Kakizaki M, et al. (1998). "Identification of single C motif-1/lymphotactin receptor XCR1". J. Biol. Chem. 273 (26): 16551–4. doi:10.1074/jbc.273.26.16551. PMID9632725.
Shan L, Qiao X, Oldham E, et al. (2000). "Identification of viral macrophage inflammatory protein (vMIP)-II as a ligand for GPR5/XCR1". Biochem. Biophys. Res. Commun. 268 (3): 938–41. doi:10.1006/bbrc.2000.2235. PMID10679309.
Maho A, Bensimon A, Vassart G, Parmentier M (2000). "Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome". Cytogenet. Cell Genet. 87 (3–4): 265–8. doi:10.1159/000015443. PMID10702689.
Kurt RA, Bauck M, Harma S, et al. (2001). "Role of C chemokine lymphotactin in mediating recruitment of antigen-specific CD62L(lo) cells in vitro and in vivo". Cell. Immunol. 209 (2): 83–8. doi:10.1006/cimm.2001.1790. PMID11446740.
Shinkai H, Morozumi T, Toki D, et al. (2005). "Genomic structure of eight porcine chemokine receptors and intergene sharing of an exon between CCR1 and XCR1". Gene. 349: 55–66. doi:10.1016/j.gene.2004.10.017. PMID15777643.
Lüttichau HR, Johnsen AH, Jurlander J, et al. (2007). "Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3". J. Biol. Chem. 282 (24): 17794–805. doi:10.1074/jbc.M702001200. PMID17403668.