BTLA
| B and T lymphocyte attenuator | |||||||||||||
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 PDB rendering based on 2aw2. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | BTLA ; BTLA1; CD272; FLJ16065; MGC129743 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 52233 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
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B and T lymphocyte attenuator, also known as BTLA, is a human gene.[1] BTLA has also been designated as CD272 (cluster of differentiation 272).
BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 (MIM 600244) and CTLA4 (MIM 123890), BTLA interacts with a B7 homolog, B7H4.[supplied by OMIM][1] However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family (TNF) receptors, not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (ligand) superfamily, member 14 (TNFSF14), also known as herpes virus etry mdiator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
References
Further reading
- Pao LI, Bedzyk WD, Persin C, Cambier JC (1997). "Molecular targets of CD45 in B cell antigen receptor signal transduction". J. Immunol. 158 (3): 1116–24. PMID 9013950.
- Pao LI, Cambier JC (1997). "Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells". J. Immunol. 158 (6): 2663–9. PMID 9058799.
- Vilen BJ, Famiglietti SJ, Carbone AM; et al. (1997). "B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation". J. Immunol. 159 (1): 231–43. PMID 9200459.
- Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Watanabe N, Gavrieli M, Sedy JR; et al. (2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nat. Immunol. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776.
- Gavrieli M, Watanabe N, Loftin SK; et al. (2004). "Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2". Biochem. Biophys. Res. Commun. 312 (4): 1236–43. PMID 14652006.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Sedy JR, Gavrieli M, Potter KG; et al. (2005). "B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator". Nat. Immunol. 6 (1): 90–8. doi:10.1038/ni1144. PMID 15568026.
- Gonzalez LC, Loyet KM, Calemine-Fenaux J; et al. (2005). "A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator". Proc. Natl. Acad. Sci. U.S.A. 102 (4): 1116–21. doi:10.1073/pnas.0409071102. PMID 15647361.
- Cheung TC, Humphreys IR, Potter KG; et al. (2005). "Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway". Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13218–23. doi:10.1073/pnas.0506172102. PMID 16131544.
- Compaan DM, Gonzalez LC, Tom I; et al. (2006). "Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex". J. Biol. Chem. 280 (47): 39553–61. doi:10.1074/jbc.M507629200. PMID 16169851.
- Otsuki N, Kamimura Y, Hashiguchi M, Azuma M (2006). "Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells". Biochem. Biophys. Res. Commun. 344 (4): 1121–7. doi:10.1016/j.bbrc.2006.03.242. PMID 16643847.
- Wang XF, Chen YJ, Wang Q; et al. (2007). "Distinct expression and inhibitory function of B and T lymphocyte attenuator on human T cells". Tissue Antigens. 69 (2): 145–53. doi:10.1111/j.1399-0039.2006.00710.x. PMID 17257317.
External links
- BTLA+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.