CD18

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
PDB rendering based on 1l3y.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1l3y​, 1yuk​
Identifiers
Symbols	ITGB2 ; LAD; LFA-1; MAC-1; CD18; LCAMB; MF17; MFI7
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20092
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), also known as CD18 or ITGB2, is a human gene.

CD18 is the beta subunit of three different structures:

• LFA-1 (paired with CD11a)
• Macrophage-1 antigen (paired with CD11b)
• Integrin alphaXbeta2 (paired with CD11c)

The ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Further reading

• Bunting M, Harris ES, McIntyre TM; et al. (2002). "Leukocyte adhesion deficiency syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands". Curr. Opin. Hematol. 9 (1): 30–5. PMID 11753075.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roos D, Law SK (2003). "Hematologically important mutations: leukocyte adhesion deficiency". Blood Cells Mol. Dis. 27 (6): 1000–4. doi:10.1006/bcmd.2001.0473. PMID 11831866.
• Gahmberg CG, Fagerholm S (2003). "Activation of leukocyte beta2-integrins". Vox Sang. 83 Suppl 1: 355–8. PMID 12617168.
• Schymeinsky J, Mócsai A, Walzog B (2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms and clinical implications". Thromb. Haemost. 98 (2): 262–73. PMID 17721605.CS1 maint: Multiple names: authors list (link)

See also

• leukocyte adhesion deficiency
• integrin

External links

• CD18+antigen at the US National Library of Medicine Medical Subject Headings (MeSH)