CDCP1

CUB domain containing protein 1
Identifiers
Symbols	CDCP1 ; CD318; SIMA135; TRASK
External IDs	Template:MGI HomoloGene: 11276
Gene ontology Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

CUB domain containing protein 1, also known as CDCP1, is a human gene. CDCP1 has also been designated as CD318 (cluster of differentiation 318).

The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Xia Y, Gil SG, Carter WG (1996). "Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein". J. Cell Biol. 132 (4): 727–40. PMID 8647901.CS1 maint: Multiple names: authors list (link)
• Scherl-Mostageer M, Sommergruber W, Abseher R; et al. (2001). "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer". Oncogene. 20 (32): 4402–8. PMID 11466621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hooper JD, Zijlstra A, Aimes RT; et al. (2003). "Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen". Oncogene. 22 (12): 1783–94. doi:10.1038/sj.onc.1206220. PMID 12660814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Conze T, Lammers R, Kuci S; et al. (2003). "CDCP1 is a novel marker for hematopoietic stem cells". Ann. N. Y. Acad. Sci. 996: 222–6. PMID 12799299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brown TA, Yang TM, Zaitsevskaia T; et al. (2004). "Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia". J. Biol. Chem. 279 (15): 14772–83. doi:10.1074/jbc.M309678200. PMID 14739293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bühring HJ, Kuçi S, Conze T; et al. (2005). "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin". Stem Cells. 22 (3): 334–43. PMID 15153610.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benes CH, Wu N, Elia AE; et al. (2005). "The C2 domain of PKCdelta is a phosphotyrosine binding domain". Cell. 121 (2): 271–80. doi:10.1016/j.cell.2005.02.019. PMID 15851033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhatt AS, Erdjument-Bromage H, Tempst P; et al. (2005). "Adhesion signaling by a novel mitotic substrate of src kinases". Oncogene. 24 (34): 5333–43. doi:10.1038/sj.onc.1208582. PMID 16007225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• André M, Le Caer JP, Greco C; et al. (2006). "Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS". Proteomics. 6 (5): 1437–49. doi:10.1002/pmic.200500180. PMID 16404722.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura H, Morii E, Ikeda JI; et al. (2006). "Role of DNA methylation for expression of novel stem cell marker CDCP1 in hematopoietic cells". Leukemia. 20 (9): 1551–6. doi:10.1038/sj.leu.2404312. PMID 16926850.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Perry SE, Robinson P, Melcher A; et al. (2007). "Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells". FEBS Lett. 581 (6): 1137–42. doi:10.1016/j.febslet.2007.02.025. PMID 17335815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uekita T, Jia L, Narisawa-Saito M; et al. (2007). "CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma". Mol. Cell. Biol. 27 (21): 7649–60. doi:10.1128/MCB.01246-07. PMID 17785447.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• CDCP1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.