ITGA6

Integrin, alpha 6
Identifiers
Symbols	ITGA6 ; CD49f; ITGA6B; VLA-6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20091
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Integrin, alpha 6, also known as ITGA6, is a human gene.

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.

See also

• Cluster of differentiation
• Integrins

Further reading

• Lipscomb EA, Mercurio AM (2006). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer Metastasis Rev. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.

External links

• CD49f+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)