TRPM6: Difference between revisions

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''TRPM6''' is a [[transient receptor potential]] [[ion channel]] associated with [[hypomagnesemia with secondary hypocalcemia]].<ref>{{cite journal |vauthors=Schlingmann KP, Weber S, Peters M, etal |title=Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family |journal=Nat. Genet. |volume=31 |issue=2 |pages=166–70 |year=2002 |pmid=12032568 |doi=10.1038/ng889}}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Transient receptor potential cation channel, subfamily M, member 6
| HGNCid = 17995
| Symbol = TRPM6
| AltSymbols =; CHAK2; HMGX; HOMG; HSH
| OMIM = 607009
| ECnumber = 
| Homologene = 9767
| MGIid = 2675603
| GeneAtlas_image1 = PBB_GE_TRPM6_221102_s_at_tn.png
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| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 140803
    | Hs_Ensembl = ENSG00000119121
    | Hs_RefseqProtein = NP_060132
    | Hs_RefseqmRNA = NM_017662
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 76527231
    | Hs_GenLoc_end = 76692830
    | Hs_Uniprot = Q9BX84
    | Mm_EntrezGene = 225997
    | Mm_Ensembl = ENSMUSG00000024727
    | Mm_RefseqmRNA = XM_987699
    | Mm_RefseqProtein = XP_992793
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 18817002
    | Mm_GenLoc_end = 18959534
    | Mm_Uniprot = Q8CIR4
  }}
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'''TRPM6''' is a [[transient receptor potential]] [[ion channel]] associated with [[hypomagnesemia with secondary hypocalcemia]].<ref>{{cite journal |author=Schlingmann KP, Weber S, Peters M, ''et al'' |title=Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family |journal=Nat. Genet. |volume=31 |issue=2 |pages=166-70 |year=2002 |pmid=12032568 |doi=10.1038/ng889}}</ref>
 
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==See also==
==See also==
* [[TRPM]]
* [[TRPM]]
* [[Ruthenium red]]


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite book | last = Islam | first = Md. Shahidul | title = Transient Receptor Potential Channels |date=January 2011 | volume = 704 | publisher = Springer |  location = Berlin | pages = 700  | series = Advances in Experimental Medicine and Biology | isbn = 978-94-007-0264-6 }}
| citations =  
*{{cite journal  | vauthors=Chubanov V, Gudermann T, Schlingmann KP |title=Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. |journal=Pflugers Arch. |volume=451 |issue= 1 |pages= 228–34 |year= 2006 |pmid= 16075242 |doi= 10.1007/s00424-005-1470-y }}
*{{cite journal  | author=Chubanov V, Gudermann T, Schlingmann KP |title=Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. |journal=Pflugers Arch. |volume=451 |issue= 1 |pages= 228-34 |year= 2006 |pmid= 16075242 |doi= 10.1007/s00424-005-1470-y }}
*{{cite journal  | vauthors=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427–50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal  | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal  | author=Bödding M |title=TRPM6: A Janus-like protein. |journal=Handb Exp Pharmacol |volume= 179|issue= 179 |pages= 299–311 |year= 2007 |pmid= 17217065 |doi= 10.1007/978-3-540-34891-7_18 }}
*{{cite journal  | author=Bödding M |title=TRPM6: A Janus-like protein. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 299-311 |year= 2007 |pmid= 17217065 |doi= 10.1007/978-3-540-34891-7_18 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|TRPM6+protein,+human}}
* {{MeshName|TRPM6+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g4}}
{{Transient receptor potential channel modulators}}
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Revision as of 00:05, 1 May 2017

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Orthologs
SpeciesHumanMouse
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Wikidata
View/Edit Human

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.[1]

See also

References

  1. ↑ Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568.

Further reading

  • Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
  • Chubanov V, Gudermann T, Schlingmann KP (2006). "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis". Pflugers Arch. 451 (1): 228–34. doi:10.1007/s00424-005-1470-y. PMID 16075242.
  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
  • Bödding M (2007). "TRPM6: A Janus-like protein". Handb Exp Pharmacol. 179 (179): 299–311. doi:10.1007/978-3-540-34891-7_18. PMID 17217065.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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