TRPM3: Difference between revisions

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{{Infobox_gene}}
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'''Transient receptor potential cation channel subfamily M member 3''' is a [[protein]] that in humans is encoded by the ''TRPM3'' [[gene]].<ref name="pmid16382100">{{cite journal | vauthors = Clapham DE, Julius D, Montell C, Schultz G | title = International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 427–50 |date=Dec 2005 | pmid = 16382100 | pmc =  | doi = 10.1124/pr.57.4.6 }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Transient receptor potential cation channel, subfamily M, member 3
| HGNCid = 17992
| Symbol = TRPM3
| AltSymbols =; GON-2; LTRPC3; MLSN2
| OMIM = 608961
| ECnumber = 
| Homologene = 62287
| MGIid = 2443101
| GeneAtlas_image1 = 216452_at
| GeneAtlas_image2 = 233022_at
| GeneAtlas_image3 = 1555252_a_at
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| DateOfBotUpdate = 03:26, 2 October 2007 (UTC)
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005262 |text = calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 80036
    | Hs_Ensembl = ENSG00000083067
    | Hs_RefseqProtein = NP_001007471
    | Hs_RefseqmRNA = NM_001007470
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 72339769
    | Hs_GenLoc_end = 73251640
    | Hs_Uniprot = Q9HCF6
    | Mm_EntrezGene = 226025
    | Mm_Ensembl = ENSMUSG00000052387
    | Mm_RefseqmRNA = NM_001035239
    | Mm_RefseqProtein = NP_001030316
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 22206216
    | Mm_GenLoc_end = 23055913
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'''Transient receptor potential cation channel, subfamily M, member 3''', also known as '''TRPM3''', is a human [[gene]].


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80036| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of [[transient receptor potential]] (TRP) channels. TRP channels are cation-selective [[ion channel|channels]] important for cellular [[calcium signaling]] and [[homeostasis]]. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.<ref>{{cite web | title = Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80036| accessdate = }}</ref>
}}
}}
TRPM3 was shown to be activated by the [[neurosteroid]] [[pregnenolone]] sulphate in pancreatic [[beta cell]]. The activation causes [[calcium]] influx and subsequent [[insulin release]], therefore it is suggested that TRPM3 modulates [[glucose]] homeostasis.<ref name="pmid18978782">{{cite journal  |vauthors=Wagner TF, Loch S, Lambert S, etal |title=Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells |journal=Nature Cell Biology |volume= 10|issue= 12|pages= 1421–30|date=November 2008 |pmid=18978782 |doi=10.1038/ncb1801 |url=}}</ref>
==See also==
* [[TRPM]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Oberwinkler J, Phillipp SE |title=TRPM3. |journal=Handb Exp Pharmacol |volume= 179|issue= 179 |pages= 253–67 |year= 2007 |pmid= 17217062 |doi=10.1007/978-3-540-34891-7_15 }}
| citations =
*{{cite journal  | vauthors=Harteneck C, Reiter B |title=TRP channels activated by extracellular hypo-osmoticity in epithelia. |journal=Biochem. Soc. Trans. |volume=35 |issue= Pt 1 |pages= 91–5 |year= 2007 |pmid= 17233610 |doi= 10.1042/BST0350091 }}
*{{cite journal  | author=Clapham DE, Julius D, Montell C, Schultz G |title=International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 427-50 |year= 2006 |pmid= 16382100 |doi= 10.1124/pr.57.4.6 }}
*{{cite journal  | author=Oberwinkler J, Phillipp SE |title=TRPM3. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 253-67 |year= 2007 |pmid= 17217062 |doi=  }}
*{{cite journal  | author=Harteneck C, Reiter B |title=TRP channels activated by extracellular hypo-osmoticity in epithelia. |journal=Biochem. Soc. Trans. |volume=35 |issue= Pt 1 |pages= 91-5 |year= 2007 |pmid= 17233610 |doi= 10.1042/BST0350091 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{MeshName|TRPM3+protein,+human}}
 
{{NLM content}}
{{Ion channels|g4}}
{{Transient receptor potential channel modulators}}
 
[[Category:Ion channels]]
 
 
{{membrane-protein-stub}}

Revision as of 11:35, 1 November 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Wikidata
View/Edit Human

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.[1]

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[2] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.[3]

See also

References

  1. ↑ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
  2. ↑ "Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3".
  3. ↑ Wagner TF, Loch S, Lambert S, et al. (November 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology. 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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