TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types.
[3]
It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.[4]
The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5.
[5][6] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.[6]
History
TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPCion channel family.[1][2]
↑ 2.02.1Zhu X, Chu PB, Peyton M, Birnbaumer L (Oct 1995). "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene". FEBS Letters. 373 (3): 193–8. doi:10.1016/0014-5793(95)01038-G. PMID7589464.
↑Xu SZ, Beech DJ (Jan 2001). "TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells". Circulation Research. 88 (1): 84–7. doi:10.1161/01.res.88.1.84. PMID11139478.
↑Skopin A, Shalygin A, Vigont V, Zimina O, Glushankova L, Mozhayeva GN, Kaznacheyeva E (Feb 2013). "TRPC1 protein forms only one type of native store-operated channels in HEK293 cells". Biochimie. 95 (2): 347–53. doi:10.1016/j.biochi.2012.10.004. PMID23079337.
↑ 6.06.1Cooper, Donald; Fowler, Melissa; Varnell, Andrew; Dietrich, A.; Birnbaumer, L.; Cooper, Donald (2012). "Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine". Nature Precedings. doi:10.1038/npre.2012.7153.
↑Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/s0092-8674(03)00716-5. PMID14505576.
