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''For the older type of computer memory, see [[DDR SDRAM]].''
{{for|the type of computer memory|DDR SDRAM}}


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Discoidin domain receptor family, member 1''', also known as '''DDR1''' or '''CD167a''' ([[cluster of differentiation]] 167a), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDR1 discoidin domain receptor family, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=780| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Discoidin domain receptor family, member 1
| HGNCid = 2730
| Symbol = DDR1
| AltSymbols =; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE
| OMIM = 600408
| ECnumber = 
| Homologene = 68212
| MGIid = 99216
| GeneAtlas_image1 = PBB_GE_DDR1_1007_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DDR1_207169_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_DDR1_208779_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004714 |text = transmembrane receptor protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 780
    | Hs_Ensembl = ENSG00000137332
    | Hs_RefseqProtein = NP_001945
    | Hs_RefseqmRNA = NM_001954
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = c6_COX
    | Hs_GenLoc_start = 30989009
    | Hs_GenLoc_end = 31005081
    | Hs_Uniprot = Q08345
    | Mm_EntrezGene = 12305
    | Mm_Ensembl = ENSMUSG00000003534
    | Mm_RefseqmRNA = NM_007584
    | Mm_RefseqProtein = NP_031610
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 35289621
    | Mm_GenLoc_end = 35312652
    | Mm_Uniprot = O35407
  }}
}}
'''Discoidin domain receptor family, member 1''', also known as '''DDR1''' or '''CD167a''' ([[cluster of differentiation]] 167a), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDR1 discoidin domain receptor family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=780| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Receptor tyrosine kinase]]s (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of [[collagen]]. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the ''[[Dictyostelium discoideum]]'' protein [[discoidin domain|discoidin]] I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the [[Discoidin domain-containing receptor 2|DDR2]] protein.<ref name="pmid23335507">{{cite journal | vauthors = Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R | title = Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling | journal = The Journal of Biological Chemistry | volume = 288 | issue = 11 | pages = 7430–7 | date = Mar 2013 | pmid = 23335507 | pmc = 3597784 | doi = 10.1074/jbc.R112.444158 }}</ref>  In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, [[esophagus|esophageal]], and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several [[Human leukocyte antigen|HLA class I]] genes. [[Alternative splicing]] of this gene results in multiple transcript variants.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: DDR1 discoidin domain receptor family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=780| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Edelhoff S, Sweetser DA, Disteche CM | title = Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C | journal = Genomics | volume = 25 | issue = 1 | pages = 309–11 | date = Jan 1995 | pmid = 7774938 | doi = 10.1016/0888-7543(95)80144-B }}
| citations =
* {{cite journal | vauthors = Shelling AN, Butler R, Jones T, Laval S, Boyle JM, Ganesan TS | title = Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16 | journal = Genomics | volume = 25 | issue = 2 | pages = 584–7 | date = Jan 1995 | pmid = 7789998 | doi = 10.1016/0888-7543(95)80065-T }}
*{{cite journal | author=Edelhoff S, Sweetser DA, Disteche CM |title=Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C. |journal=Genomics |volume=25 |issue= 1 |pages= 309-11 |year= 1995 |pmid= 7774938 |doi= }}
* {{cite journal | vauthors = Weiner TM, Liu ET, Craven RJ, Cance WG | title = Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors | journal = Annals of Surgical Oncology | volume = 1 | issue = 1 | pages = 18–27 | date = Jan 1994 | pmid = 7834423 | doi = 10.1007/BF02303537 }}
*{{cite journal | author=Shelling AN, Butler R, Jones T, ''et al.'' |title=Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16. |journal=Genomics |volume=25 |issue= 2 |pages= 584-7 |year= 1995 |pmid= 7789998 |doi= }}
* {{cite journal | vauthors = Laval S, Butler R, Shelling AN, Hanby AM, Poulsom R, Ganesan TS | title = Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line | journal = Cell Growth & Differentiation | volume = 5 | issue = 11 | pages = 1173–83 | date = Nov 1994 | pmid = 7848919 | doi =  }}
*{{cite journal | author=Weiner TM, Liu ET, Craven RJ, Cance WG |title=Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors. |journal=Ann. Surg. Oncol. |volume=1 |issue= 1 |pages= 18-27 |year= 1995 |pmid= 7834423 |doi= }}
* {{cite journal | vauthors = Kato JY, Matsuoka M, Strom DK, Sherr CJ | title = Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase | journal = Molecular and Cellular Biology | volume = 14 | issue = 4 | pages = 2713–21 | date = Apr 1994 | pmid = 8139570 | pmc = 358637 | doi = 10.1128/MCB.14.4.2713 }}
*{{cite journal | author=Laval S, Butler R, Shelling AN, ''et al.'' |title=Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line. |journal=Cell Growth Differ. |volume=5 |issue= 11 |pages= 1173-83 |year= 1995 |pmid= 7848919 |doi=  }}
* {{cite journal | vauthors = Di Marco E, Cutuli N, Guerra L, Cancedda R, De Luca M | title = Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues | journal = The Journal of Biological Chemistry | volume = 268 | issue = 32 | pages = 24290–5 | date = Nov 1993 | pmid = 8226977 | doi =  }}
*{{cite journal | author=Kato JY, Matsuoka M, Strom DK, Sherr CJ |title=Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2713-21 |year= 1994 |pmid= 8139570 |doi= }}
* {{cite journal | vauthors = Perez JL, Shen X, Finkernagel S, Sciorra L, Jenkins NA, Gilbert DJ, Copeland NG, Wong TW | title = Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain | journal = Oncogene | volume = 9 | issue = 1 | pages = 211–9 | date = Jan 1994 | pmid = 8302582 | doi =  }}
*{{cite journal | author=Di Marco E, Cutuli N, Guerra L, ''et al.'' |title=Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24290-5 |year= 1993 |pmid= 8226977 |doi=  }}
* {{cite journal | vauthors = Johnson JD, Edman JC, Rutter WJ | title = A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 12 | pages = 5677–81 | date = Jun 1993 | pmid = 8390675 | pmc = 46784 | doi = 10.1073/pnas.90.12.5677 }}
*{{cite journal | author=Perez JL, Shen X, Finkernagel S, ''et al.'' |title=Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain. |journal=Oncogene |volume=9 |issue= 1 |pages= 211-9 |year= 1994 |pmid= 8302582 |doi=  }}
* {{cite journal | vauthors = Perez JL, Jing SQ, Wong TW | title = Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines | journal = Oncogene | volume = 12 | issue = 7 | pages = 1469–77 | date = Apr 1996 | pmid = 8622863 | doi =  }}
*{{cite journal | author=Johnson JD, Edman JC, Rutter WJ |title=A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5677-81 |year= 1993 |pmid= 8390675 |doi= }}
* {{cite journal | vauthors = Valent A, Meddeb M, Danglot G, Duverger A, Nguyen VC, Bernheim A | title = Assignment of the NTRK4 (trkE) gene to chromosome 6p21 | journal = Human Genetics | volume = 98 | issue = 1 | pages = 12–5 | date = Jul 1996 | pmid = 8682498 | doi = 10.1007/s004390050152 }}
*{{cite journal | author=Perez JL, Jing SQ, Wong TW |title=Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines. |journal=Oncogene |volume=12 |issue= 7 |pages= 1469-77 |year= 1996 |pmid= 8622863 |doi=  }}
* {{cite journal | vauthors = Playford MP, Butler RJ, Wang XC, Katso RM, Cooke IE, Ganesan TS | title = The genomic structure of discoidin receptor tyrosine kinase | journal = Genome Research | volume = 6 | issue = 7 | pages = 620–7 | date = Jul 1996 | pmid = 8796349 | doi = 10.1101/gr.6.7.620 }}
*{{cite journal | author=Valent A, Meddeb M, Danglot G, ''et al.'' |title=Assignment of the NTRK4 (trkE) gene to chromosome 6p21. |journal=Hum. Genet. |volume=98 |issue= 1 |pages= 12-5 |year= 1996 |pmid= 8682498 |doi= }}
* {{cite journal | vauthors = Sakuma S, Saya H, Tada M, Nakao M, Fujiwara T, Roth JA, Sawamura Y, Shinohe Y, Abe H | title = Receptor protein tyrosine kinase DDR is up-regulated by p53 protein | journal = FEBS Letters | volume = 398 | issue = 2-3 | pages = 165–9 | date = Dec 1996 | pmid = 8977099 | doi = 10.1016/S0014-5793(96)01234-3 }}
*{{cite journal | author=Playford MP, Butler RJ, Wang XC, ''et al.'' |title=The genomic structure of discoidin receptor tyrosine kinase. |journal=Genome Res. |volume=6 |issue= 7 |pages= 620-7 |year= 1996 |pmid= 8796349 |doi= }}
* {{cite journal | vauthors = Nemoto T, Ohashi K, Akashi T, Johnson JD, Hirokawa K | title = Overexpression of protein tyrosine kinases in human esophageal cancer | journal = Pathobiology | volume = 65 | issue = 4 | pages = 195–203 | year = 1998 | pmid = 9396043 | doi = 10.1159/000164123 }}
*{{cite journal | author=Sakuma S, Saya H, Tada M, ''et al.'' |title=Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. |journal=FEBS Lett. |volume=398 |issue= 2-3 |pages= 165-9 |year= 1997 |pmid= 8977099 |doi= }}
* {{cite journal | vauthors = Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, Kuma K, Yamashita S, Niwa M | title = Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid | journal = Endocrinology | volume = 139 | issue = 3 | pages = 852–8 | date = Mar 1998 | pmid = 9492013 | doi = 10.1210/en.139.3.852 }}
*{{cite journal | author=Nemoto T, Ohashi K, Akashi T, ''et al.'' |title=Overexpression of protein tyrosine kinases in human esophageal cancer. |journal=Pathobiology |volume=65 |issue= 4 |pages= 195-203 |year= 1998 |pmid= 9396043 |doi= }}
* {{cite journal | vauthors = Vogel W, Gish GD, Alves F, Pawson T | title = The discoidin domain receptor tyrosine kinases are activated by collagen | journal = Molecular Cell | volume = 1 | issue = 1 | pages = 13–23 | date = Dec 1997 | pmid = 9659899 | doi = 10.1016/S1097-2765(00)80003-9 }}
*{{cite journal | author=Tanaka K, Nagayama Y, Nakano T, ''et al.'' |title=Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid. |journal=Endocrinology |volume=139 |issue= 3 |pages= 852-8 |year= 1998 |pmid= 9492013 |doi= }}
* {{cite journal | vauthors = Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD | title = An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors | journal = Molecular Cell | volume = 1 | issue = 1 | pages = 25–34 | date = Dec 1997 | pmid = 9659900 | doi = 10.1016/S1097-2765(00)80004-0 }}
*{{cite journal | author=Vogel W, Gish GD, Alves F, Pawson T |title=The discoidin domain receptor tyrosine kinases are activated by collagen. |journal=Mol. Cell |volume=1 |issue= 1 |pages= 13-23 |year= 1998 |pmid= 9659899 |doi= }}
* {{cite journal | vauthors = Vogel W, Brakebusch C, Fässler R, Alves F, Ruggiero F, Pawson T | title = Discoidin domain receptor 1 is activated independently of beta(1) integrin | journal = The Journal of Biological Chemistry | volume = 275 | issue = 8 | pages = 5779–84 | date = Feb 2000 | pmid = 10681566 | doi = 10.1074/jbc.275.8.5779 }}
*{{cite journal | author=Shrivastava A, Radziejewski C, Campbell E, ''et al.'' |title=An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. |journal=Mol. Cell |volume=1 |issue= 1 |pages= 25-34 |year= 1998 |pmid= 9659900 |doi= }}
* {{cite journal | vauthors = Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA | title = Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors | journal = FASEB Journal | volume = 14 | issue = 7 | pages = 973–81 | date = May 2000 | pmid = 10783152 | doi =  }}
*{{cite journal | author=Vogel W, Brakebusch C, Fässler R, ''et al.'' |title=Discoidin domain receptor 1 is activated independently of beta(1) integrin. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5779-84 |year= 2000 |pmid= 10681566 |doi= }}
* {{cite journal | vauthors = Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB | title = Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors | journal = Neurosurgery | volume = 47 | issue = 6 | pages = 1400–9 | date = Dec 2000 | pmid = 11126911 | doi = 10.1097/00006123-200012000-00028 }}
*{{cite journal | author=Foehr ED, Tatavos A, Tanabe E, ''et al.'' |title=Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors. |journal=FASEB J. |volume=14 |issue= 7 |pages= 973-81 |year= 2000 |pmid= 10783152 |doi=  }}
* {{cite journal | vauthors = Mohan RR, Mohan RR, Wilson SE | title = Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea | journal = Experimental Eye Research | volume = 72 | issue = 1 | pages = 87–92 | date = Jan 2001 | pmid = 11133186 | doi = 10.1006/exer.2000.0932 }}
*{{cite journal | author=Weiner HL, Huang H, Zagzag D, ''et al.'' |title=Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors. |journal=Neurosurgery |volume=47 |issue= 6 |pages= 1400-9 |year= 2001 |pmid= 11126911 |doi=  }}
*{{cite journal | author=Mohan RR, Mohan RR, Wilson SE |title=Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea. |journal=Exp. Eye Res. |volume=72 |issue= 1 |pages= 87-92 |year= 2001 |pmid= 11133186 |doi= 10.1006/exer.2000.0932 }}
}}
{{refend}}
{{refend}}


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{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Tyrosine kinases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
{{membrane-protein-stub}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Tyrosine kinase receptors]]

Latest revision as of 07:45, 26 October 2018

For the type of computer memory, see DDR SDRAM.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Discoidin domain receptor family, member 1, also known as DDR1 or CD167a (cluster of differentiation 167a), is a human gene.[1]

Function

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the DDR2 protein.[2] In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DDR1 discoidin domain receptor family, member 1".
  2. ↑ Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G, Fridman R (Mar 2013). "Discoidin domain receptors: unique receptor tyrosine kinases in collagen-mediated signaling". The Journal of Biological Chemistry. 288 (11): 7430–7. doi:10.1074/jbc.R112.444158. PMC 3597784. PMID 23335507.

Further reading

  • Edelhoff S, Sweetser DA, Disteche CM (Jan 1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C". Genomics. 25 (1): 309–11. doi:10.1016/0888-7543(95)80144-B. PMID 7774938.
  • Shelling AN, Butler R, Jones T, Laval S, Boyle JM, Ganesan TS (Jan 1995). "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16". Genomics. 25 (2): 584–7. doi:10.1016/0888-7543(95)80065-T. PMID 7789998.
  • Weiner TM, Liu ET, Craven RJ, Cance WG (Jan 1994). "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors". Annals of Surgical Oncology. 1 (1): 18–27. doi:10.1007/BF02303537. PMID 7834423.
  • Laval S, Butler R, Shelling AN, Hanby AM, Poulsom R, Ganesan TS (Nov 1994). "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line". Cell Growth & Differentiation. 5 (11): 1173–83. PMID 7848919.
  • Kato JY, Matsuoka M, Strom DK, Sherr CJ (Apr 1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". Molecular and Cellular Biology. 14 (4): 2713–21. doi:10.1128/MCB.14.4.2713. PMC 358637. PMID 8139570.
  • Di Marco E, Cutuli N, Guerra L, Cancedda R, De Luca M (Nov 1993). "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues". The Journal of Biological Chemistry. 268 (32): 24290–5. PMID 8226977.
  • Perez JL, Shen X, Finkernagel S, Sciorra L, Jenkins NA, Gilbert DJ, Copeland NG, Wong TW (Jan 1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene. 9 (1): 211–9. PMID 8302582.
  • Johnson JD, Edman JC, Rutter WJ (Jun 1993). "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain". Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5677–81. doi:10.1073/pnas.90.12.5677. PMC 46784. PMID 8390675.
  • Perez JL, Jing SQ, Wong TW (Apr 1996). "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines". Oncogene. 12 (7): 1469–77. PMID 8622863.
  • Valent A, Meddeb M, Danglot G, Duverger A, Nguyen VC, Bernheim A (Jul 1996). "Assignment of the NTRK4 (trkE) gene to chromosome 6p21". Human Genetics. 98 (1): 12–5. doi:10.1007/s004390050152. PMID 8682498.
  • Playford MP, Butler RJ, Wang XC, Katso RM, Cooke IE, Ganesan TS (Jul 1996). "The genomic structure of discoidin receptor tyrosine kinase". Genome Research. 6 (7): 620–7. doi:10.1101/gr.6.7.620. PMID 8796349.
  • Sakuma S, Saya H, Tada M, Nakao M, Fujiwara T, Roth JA, Sawamura Y, Shinohe Y, Abe H (Dec 1996). "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein". FEBS Letters. 398 (2–3): 165–9. doi:10.1016/S0014-5793(96)01234-3. PMID 8977099.
  • Nemoto T, Ohashi K, Akashi T, Johnson JD, Hirokawa K (1998). "Overexpression of protein tyrosine kinases in human esophageal cancer". Pathobiology. 65 (4): 195–203. doi:10.1159/000164123. PMID 9396043.
  • Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, Kuma K, Yamashita S, Niwa M (Mar 1998). "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid". Endocrinology. 139 (3): 852–8. doi:10.1210/en.139.3.852. PMID 9492013.
  • Vogel W, Gish GD, Alves F, Pawson T (Dec 1997). "The discoidin domain receptor tyrosine kinases are activated by collagen". Molecular Cell. 1 (1): 13–23. doi:10.1016/S1097-2765(00)80003-9. PMID 9659899.
  • Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD (Dec 1997). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular Cell. 1 (1): 25–34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900.
  • Vogel W, Brakebusch C, Fässler R, Alves F, Ruggiero F, Pawson T (Feb 2000). "Discoidin domain receptor 1 is activated independently of beta(1) integrin". The Journal of Biological Chemistry. 275 (8): 5779–84. doi:10.1074/jbc.275.8.5779. PMID 10681566.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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