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{{Infobox_gene}}
{{PBB_Controls
'''EGF, latrophilin and seven transmembrane domain-containing protein 1''' is a [[latrophilin]]-like [[orphan receptor]] of the [[adhesion G protein-coupled receptor]] family. In humans this [[protein]] is encoded by the ''ELTD1'' [[gene]].<ref name="pmid11050079">{{cite journal | vauthors = Nechiporuk T, Urness LD, Keating MT | title = ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily | journal = J Biol Chem | volume = 276 | issue = 6 | pages = 4150–4157 |date=May 2001 | pmid = 11050079 | pmc =  | doi = 10.1074/jbc.M004814200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64123| accessdate = }}</ref> ELTD1 appears to have a role in [[angiogenesis]], both physiological and pathological, as well as [[glioblastoma]].<ref>{{cite journal|last1=Dricu|first1=Anica|last2=Serban|first2=Florentina|last3=Artene|first3=Stefan-Alexandru|last4=Georgescu|first4=Ada Maria|last5=Purcaru|first5=Stefana Oana|last6=Tache|first6=Daniela Elise|last7=Alexandru|first7=Oana|title=Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker|journal=OncoTargets and Therapy|date=December 2015|pages=3767|doi=10.2147/OTT.S93843}}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = EGF, latrophilin and seven transmembrane domain containing 1
| HGNCid = 20822
| Symbol = ELTD1
| AltSymbols =; ETL; KPG_003
| OMIM = 
| ECnumber = 
| Homologene = 11170
| MGIid = 2655562
| GeneAtlas_image1 = PBB_GE_ELTD1_219134_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64123
    | Hs_Ensembl = ENSG00000162618
    | Hs_RefseqProtein = XP_371262
    | Hs_RefseqmRNA = XM_371262
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 79128037
    | Hs_GenLoc_end = 79244991
    | Hs_Uniprot = Q9HBW9
    | Mm_EntrezGene = 170757
    | Mm_Ensembl = ENSMUSG00000039167
    | Mm_RefseqmRNA = NM_133222
    | Mm_RefseqProtein = NP_573485
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 151375273
    | Mm_GenLoc_end = 151482474
    | Mm_Uniprot = Q923X1
  }}
}}
'''EGF, latrophilin and seven transmembrane domain containing 1''', also known as '''ELTD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64123| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =  
| summary_text =  
}}


==See also==
==See also==
* [[Latrophilin receptor]]
* [[Latrophilin]]


==References==
==References==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nechiporuk T, Urness LD, Keating MT |title=ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4150-7 |year= 2001 |pmid= 11050079 |doi= 10.1074/jbc.M004814200 }}
*{{cite journal  | author=Venter JC |title=The sequence of the human genome |journal=Science |volume=291 |issue= 5507 |pages= 1304–1351 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 |name-list-format=vanc| author2=Adams MD | author3=Myers EW | display-authors=3  | last4=Li  | first4=PW  | last5=Mural  | first5=RJ  | last6=Sutton  | first6=GG  | last7=Smith  | first7=HO  | last8=Yandell  | first8=M  | last9=Evans  | first9=CA }}
*{{cite journal | author=Venter JC, Adams MD, Myers EW, ''et al.'' |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304-51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Clark HF |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–2270 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697  |name-list-format=vanc| author2=Gurney AL  | author3=Abaya E  | display-authors=3  | last4=Baker  | first4=K  | last5=Baldwin  | first5=D  | last6=Brush  | first6=J  | last7=Chen  | first7=J  | last8=Chow  | first8=B  | last9=Chui  | first9=C }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | author=Bjarnadóttir TK |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 |name-list-format=vanc| author2=Fredriksson R  | author3=Höglund PJ  | display-authors=3  | last4=Gloriam  | first4=David E.  | last5=Lagerström  | first5=Malin C.  | last6=Schiöth  | first6=Helgi B. }}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Liu T |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–2080 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943  |name-list-format=vanc| author2=Qian WJ  | author3=Gritsenko MA  | display-authors=3  | last4=Camp  | first4=David G.  | last5=Monroe  | first5=Matthew E.  | last6=Moore  | first6=Ronald J.  | last7=Smith  | first7=Richard D. }}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
 
[[Category:Adhesion GPCRs]]




{{WikiDoc Sources}}
{{transmembranereceptor-stub}}

Latest revision as of 00:28, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

EGF, latrophilin and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ELTD1 gene.[1][2] ELTD1 appears to have a role in angiogenesis, both physiological and pathological, as well as glioblastoma.[3]

See also

References

  1. ↑ Nechiporuk T, Urness LD, Keating MT (May 2001). "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily". J Biol Chem. 276 (6): 4150–4157. doi:10.1074/jbc.M004814200. PMID 11050079.
  2. ↑ "Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1".
  3. ↑ Dricu, Anica; Serban, Florentina; Artene, Stefan-Alexandru; Georgescu, Ada Maria; Purcaru, Stefana Oana; Tache, Daniela Elise; Alexandru, Oana (December 2015). "Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker". OncoTargets and Therapy: 3767. doi:10.2147/OTT.S93843.

Further reading


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