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{{Infobox_gene}}
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'''G protein-coupled receptor 81''', also known as '''GPR81''', is a [[protein]] that in humans is encoded by the '''GPR81''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR81 G protein-coupled receptor 81| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27198| accessdate = }}</ref><ref name="pmid11574155">{{cite journal | vauthors = Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 | date = September 2001 | pmid = 11574155 | doi = 10.1016/S0378-1119(01)00651-5 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[G protein-coupled receptor]]s (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric [[G protein]]s.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 81
| HGNCid = 4532
| Symbol = GPR81
| AltSymbols =; FKSG80; GPR104; TA-GPCR
| OMIM = 606923
| ECnumber = 
| Homologene = 13060
| MGIid = 2441671
| GeneAtlas_image1 = PBB_GE_GPR81_gnf1h00809_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27198
    | Hs_Ensembl = ENSG00000196917
    | Hs_RefseqProtein = NP_115943
    | Hs_RefseqmRNA = NM_032554
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 121776684
    | Hs_GenLoc_end = 121781082
    | Hs_Uniprot = Q9BXC0
    | Mm_EntrezGene = 243270
    | Mm_Ensembl = ENSMUSG00000049241
    | Mm_RefseqmRNA = NM_175520
    | Mm_RefseqProtein = NP_780729
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 124139189
    | Mm_GenLoc_end = 124140220
    | Mm_Uniprot = Q8C131
  }}
}}
'''G protein-coupled receptor 81''', also known as '''GPR81''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR81 G protein-coupled receptor 81| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27198| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Lactic acid|Lactate]] activates the GPR81 receptor which in turn inhibits [[lipolysis]] in [[adipocyte|fat cell]]s.<ref name="pmid19047060">{{cite journal | vauthors = Liu C, Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F, Lovenberg TW | title = Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81 | journal = The Journal of Biological Chemistry | volume = 284 | issue = 5 | pages = 2811–22 | date = January 2009 | pmid = 19047060 | doi = 10.1074/jbc.M806409200 }}</ref><ref name="pmid18952058">{{cite journal | vauthors = Cai TQ, Ren N, Jin L, Cheng K, Kash S, Chen R, Wright SD, Taggart AK, Waters MG | title = Role of GPR81 in lactate-mediated reduction of adipose lipolysis | journal = Biochemical and Biophysical Research Communications | volume = 377 | issue = 3 | pages = 987–91 | date = December 2008 | pmid = 18952058 | doi = 10.1016/j.bbrc.2008.10.088 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text = G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GPR81 G protein-coupled receptor 81| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27198| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Letters | volume = 520 | issue = 1-3 | pages = 97–101 | date = June 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 }}
| citations =
* {{cite journal | vauthors = Mao M, Biery MC, Kobayashi SV, Ward T, Schimmack G, Burchard J, Schelter JM, Dai H, He YD, Linsley PS | title = T lymphocyte activation gene identification by coregulated expression on DNA microarrays | journal = Genomics | volume = 83 | issue = 6 | pages = 989–99 | date = June 2004 | pmid = 15177553 | doi = 10.1016/j.ygeno.2003.12.019 }}
*{{cite journal  | author=Lee DK, Nguyen T, Lynch KR, ''et al.'' |title=Discovery and mapping of ten novel G protein-coupled receptor genes. |journal=Gene |volume=275 |issue= 1 |pages= 83-91 |year= 2001 |pmid= 11574155 |doi=  }}
* {{cite journal | vauthors = Madaan A, Nadeau-Vallée M, Rivera JC, Obari D, Hou X, Sierra EM, Girard S, Olson DM, Chemtob S | title = Lactate produced during labor modulates uterine inflammation via GPR81&nbsp;(HCA1) | journal = American Journal of Obstetrics and Gynecology | date = September 2016 | pmid = 27615440 | doi = 10.1016/j.ajog.2016.09.072 }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Mao M, Biery MC, Kobayashi SV, ''et al.'' |title=T lymphocyte activation gene identification by coregulated expression on DNA microarrays. |journal=Genomics |volume=83 |issue= 6 |pages= 989-99 |year= 2005 |pmid= 15177553 |doi= 10.1016/j.ygeno.2003.12.019 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{G protein-coupled receptors}}
{{WikiDoc Sources}}
 
[[Category:G protein coupled receptors]]
 
 
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Latest revision as of 01:00, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-coupled receptor 81, also known as GPR81, is a protein that in humans is encoded by the GPR81 gene.[1][2]

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[1]

Lactate activates the GPR81 receptor which in turn inhibits lipolysis in fat cells.[3][4]

References

  1. ↑ 1.0 1.1 "Entrez Gene: GPR81 G protein-coupled receptor 81".
  2. ↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
  3. ↑ Liu C, Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F, Lovenberg TW (January 2009). "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81". The Journal of Biological Chemistry. 284 (5): 2811–22. doi:10.1074/jbc.M806409200. PMID 19047060.
  4. ↑ Cai TQ, Ren N, Jin L, Cheng K, Kash S, Chen R, Wright SD, Taggart AK, Waters MG (December 2008). "Role of GPR81 in lactate-mediated reduction of adipose lipolysis". Biochemical and Biophysical Research Communications. 377 (3): 987–91. doi:10.1016/j.bbrc.2008.10.088. PMID 18952058.

Further reading

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878.
  • Mao M, Biery MC, Kobayashi SV, Ward T, Schimmack G, Burchard J, Schelter JM, Dai H, He YD, Linsley PS (June 2004). "T lymphocyte activation gene identification by coregulated expression on DNA microarrays". Genomics. 83 (6): 989–99. doi:10.1016/j.ygeno.2003.12.019. PMID 15177553.
  • Madaan A, Nadeau-Vallée M, Rivera JC, Obari D, Hou X, Sierra EM, Girard S, Olson DM, Chemtob S (September 2016). "Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1)". American Journal of Obstetrics and Gynecology. doi:10.1016/j.ajog.2016.09.072. PMID 27615440.


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