Prokineticin receptor 2: Difference between revisions
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== Further reading == | == Further reading == | ||
{{refbegin|33em}} | {{refbegin|33em}} | ||
* {{cite journal | vauthors = Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY | title = Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 22 | pages = 19276–80 | date = May 2002 | pmid = 11886876 | doi = 10.1074/jbc.M202139200 }} | * {{cite journal | vauthors = Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY | title = Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 22 | pages = 19276–80 | date = May 2002 | pmid = 11886876 | doi = 10.1074/jbc.M202139200 | url = http://www.jbc.org/content/277/22/19276.full.pdf }} | ||
* {{cite journal | vauthors = Soga T, ((Matsumoto Si)), Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K | title = Molecular cloning and characterization of prokineticin receptors | journal = Biochimica et Biophysica Acta | volume = 1579 | issue = 2-3 | pages = 173–9 | date = December 2002 | pmid = 12427552 | doi = 10.1016/S0167-4781(02)00546-8 }} | * {{cite journal | vauthors = Soga T, ((Matsumoto Si)), Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K | title = Molecular cloning and characterization of prokineticin receptors | journal = Biochimica et Biophysica Acta | volume = 1579 | issue = 2-3 | pages = 173–9 | date = December 2002 | pmid = 12427552 | doi = 10.1016/S0167-4781(02)00546-8 }} | ||
* {{cite journal | vauthors = Battersby S, Critchley HO, Morgan K, Millar RP, Jabbour HN | title = Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 5 | pages = 2463–9 | date = May 2004 | pmid = 15126578 | doi = 10.1210/jc.2003-032012 }} | * {{cite journal | vauthors = Battersby S, Critchley HO, Morgan K, Millar RP, Jabbour HN | title = Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 5 | pages = 2463–9 | date = May 2004 | pmid = 15126578 | doi = 10.1210/jc.2003-032012 }} | ||
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{{NLM content}} | {{NLM content}} | ||
{{G protein-coupled receptors}} | {{G protein-coupled receptors}} | ||
[[Category:G protein coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
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Prokineticin receptor 2 (PKR2), is a G protein-coupled receptor encoded by the PROKR2 gene in humans.[1]
Function
Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins.[1]
Mutations in the PROKR2 (also known as KAL3) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[2]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: PROKR2 prokineticin receptor 2".
- ↑ Narula HS, Carlson HE (November 2014). "Gynaecomastia--pathophysiology, diagnosis and treatment". Nature Reviews. Endocrinology. 10 (11): 684–98. doi:10.1038/nrendo.2014.139. PMID 25112235.
Further reading
- Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY (May 2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor" (PDF). The Journal of Biological Chemistry. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.
- Soga T, Matsumoto Si, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K (December 2002). "Molecular cloning and characterization of prokineticin receptors". Biochimica et Biophysica Acta. 1579 (2–3): 173–9. doi:10.1016/S0167-4781(02)00546-8. PMID 12427552.
- Battersby S, Critchley HO, Morgan K, Millar RP, Jabbour HN (May 2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". The Journal of Clinical Endocrinology and Metabolism. 89 (5): 2463–9. doi:10.1210/jc.2003-032012. PMID 15126578.
- Pasquali D, Rossi V, Staibano S, De Rosa G, Chieffi P, Prezioso D, Mirone V, Mascolo M, Tramontano D, Bellastella A, Sinisi AA (September 2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi:10.1210/en.2006-0614. PMID 16763065.
- Dodé C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML, Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A, Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP (October 2006). "Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2". PLoS Genetics. 2 (10): e175. doi:10.1371/journal.pgen.0020175. PMC 1617130. PMID 17054399.
External links
- GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome
- "Prokineticin Receptors: PKR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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