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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details.
-->{{Infobox_gene}}
'''Brain-specific angiogenesis inhibitor 1''' is a [[protein]] that in humans is encoded by the ''BAI1'' [[gene]].<ref name="pmid9533023">{{cite journal | vauthors = Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1-2 | pages = 103–8 | date = Apr 1998 | pmid = 9533023 | pmc =  | doi = 10.1159/000134693 }}</ref><ref name="entrez"/>  It is a member of the [[adhesion-GPCRs|adhesion-GPCR]] family of receptors.<ref name="isbn1-4419-7912-3">{{cite book | author = Stacey M, Yona S | title = AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 1-4419-7912-3 }}</ref>


== Function ==
[[Angiogenesis]] is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and [[metastasis]] of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators.  BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype [[p53]]. There are two other brain-specific angiogenesis inhibitor genes, designated [[BAI2]] and [[BAI3]] which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of [[glioblastoma]]s.<ref name="entrez">{{cite web | title = Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=575| accessdate = }}</ref>
== Interactions ==
Brain-specific angiogenesis inhibitor 1 has been shown to [[Protein-protein interaction|interact]] with [[BAIAP3]]<ref name="pmid9790924">{{cite journal | vauthors = Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y | title = Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 251 | issue = 1 | pages = 158–65 | date = Oct 1998 | pmid = 9790924 | doi = 10.1006/bbrc.1998.9408 }}</ref> and [[MAGI1]].<ref name="pmid9647739">{{cite journal | vauthors = Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 597–604 | date = Jun 1998 | pmid = 9647739 | doi = 10.1006/bbrc.1998.8603 }}</ref>
==Model organisms==
[[Model organism]]s have been used in the study of BAI1 function. A conditional [[knockout mouse]] line called ''Bai1<sup>tm2a(EUCOMM)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Bai1#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}</ref> Additional screens performed:  - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Bai1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref> - in-depth bone and cartilage phenotyping<ref name="obcd_ref">{{cite web |url=http://www.boneandcartilage.com/ |title=OBCD Consortium}}</ref>
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
|+ ''Bai1'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref"/><ref name="obcd_ref"/>
|-
| Peripheral blood leukocytes 6 Weeks || bgcolor="#488ED3"|Normal
|-
| ''[[Haematology]]'' 6 Weeks || bgcolor="#488ED3"|Normal
|-
| Insulin || bgcolor="#488ED3"|Normal
|-
| Homozygous viability at P14 || bgcolor="#488ED3"|Normal
|-
| Homozygous Fertility || bgcolor="#488ED3"|Normal
|-
| General Observations || bgcolor="#C40000"|Abnormal
|-
| Body weight || bgcolor="#488ED3"|Normal
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
|-
| Grip strength || bgcolor="#488ED3"|Normal
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#C40000"|Abnormal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#C40000"|Abnormal
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#C40000"|Abnormal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
|-
| Spleen Immunophenotyping || bgcolor="#488ED3"|Normal
|-
| Mesenteric Lymph Node Immunophenotyping || bgcolor="#488ED3"|Normal
|-
| Epidermal Immune Composition || bgcolor="#488ED3"|Normal
|-
|}


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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Brain-specific angiogenesis inhibitor 1
| HGNCid = 943
| Symbol = BAI1
| AltSymbols =; FLJ41988
| OMIM = 602682
| ECnumber = 
| Homologene = 1287
| MGIid = 1933736
| GeneAtlas_image1 = PBB_GE_BAI1_206083_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016527 |text = brain-specific angiogenesis inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 575
    | Hs_Ensembl = ENSG00000181790
    | Hs_RefseqProtein = XP_001130169
    | Hs_RefseqmRNA = XM_001130169
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 143542379
    | Hs_GenLoc_end = 143623348
    | Hs_Uniprot = O14514
    | Mm_EntrezGene = 107831
    | Mm_Ensembl = ENSMUSG00000034730
    | Mm_RefseqmRNA = NM_174991
    | Mm_RefseqProtein = NP_778156
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 74344086
    | Mm_GenLoc_end = 74416719
    | Mm_Uniprot = Q80T36
  }}
}}
'''Brain-specific angiogenesis inhibitor 1''', also known as '''BAI1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=575| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators.  BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas<ref name="entrez">{{cite web | title = Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=575| accessdate = }}</ref>
}}


<br />
==References==
==References==
{{reflist}}
{{reflist|33em}}
==Further reading==
 
{{refbegin | 2}}
==External links==
{{PBB_Further_reading
* {{UCSC gene info|ADGRB1}}
| citations =
 
*{{cite journal | author=Van Meir EG, Polverini PJ, Chazin VR, ''et al.'' |title=Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. |journal=Nat. Genet. |volume=8 |issue= 2 |pages= 171-6 |year= 1995 |pmid= 7531056 |doi= 10.1038/ng1094-171 }}
== Further reading ==
*{{cite journal | author=Nishimori H, Shiratsuchi T, Urano T, ''et al.'' |title=A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. |journal=Oncogene |volume=15 |issue= 18 |pages= 2145-50 |year= 1997 |pmid= 9393972 |doi= }}
{{refbegin|33em}}
*{{cite journal  | author=Shiratsuchi T, Nishimori H, Ichise H, ''et al.'' |title=Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 103-8 |year= 1998 |pmid= 9533023 |doi=  }}
* {{cite journal | vauthors = Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, de Tribolet N, Cavenee WK | title = Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells | journal = Nature Genetics | volume = 8 | issue = 2 | pages = 171–6 | date = Oct 1994 | pmid = 7531056 | doi = 10.1038/ng1094-171 }}
*{{cite journal | author=Shiratsuchi T, Futamura M, Oda K, ''et al.'' |title=Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 597-604 |year= 1998 |pmid= 9647739 |doi= 10.1006/bbrc.1998.8603 }}
* {{cite journal | vauthors = Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, Yoshida S, Ono M, Kuwano M, Nakamura Y, Tokino T | title = A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis | journal = Oncogene | volume = 15 | issue = 18 | pages = 2145–50 | date = Oct 1997 | pmid = 9393972 | doi = 10.1038/sj.onc.1201542 }}
*{{cite journal | author=Fukushima Y, Oshika Y, Tsuchida T, ''et al.'' |title=Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer. |journal=Int. J. Oncol. |volume=13 |issue= 5 |pages= 967-70 |year= 1998 |pmid= 9772287 |doi= }}
* {{cite journal | vauthors = Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T | title = Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 597–604 | date = Jun 1998 | pmid = 9647739 | doi = 10.1006/bbrc.1998.8603 }}
*{{cite journal | author=Shiratsuchi T, Oda K, Nishimori H, ''et al.'' |title=Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 1 |pages= 158-65 |year= 1998 |pmid= 9790924 |doi= 10.1006/bbrc.1998.9408 }}
* {{cite journal | vauthors = Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Ueyama Y, Tamaoki N, Nakamura M | title = Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer | journal = International Journal of Oncology | volume = 13 | issue = 5 | pages = 967–70 | date = Nov 1998 | pmid = 9772287 | doi = 10.3892/ijo.13.5.967 }}
*{{cite journal | author=Oda K, Shiratsuchi T, Nishimori H, ''et al.'' |title=Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 75-82 |year= 1999 |pmid= 10343108 |doi= }}
* {{cite journal | vauthors = Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y | title = Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1 | journal = Biochemical and Biophysical Research Communications | volume = 251 | issue = 1 | pages = 158–65 | date = Oct 1998 | pmid = 9790924 | doi = 10.1006/bbrc.1998.9408 }}
*{{cite journal | author=Wu Y, Dowbenko D, Spencer S, ''et al.'' |title=Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21477-85 |year= 2000 |pmid= 10748157 |doi= 10.1074/jbc.M909741199 }}
* {{cite journal | vauthors = Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, Nakamura Y, Tokino T | title = Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1 | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1-2 | pages = 75–82 | year = 1999 | pmid = 10343108 | doi = 10.1159/000015219 }}
*{{cite journal | author=Koh JT, Lee ZH, Ahn KY, ''et al.'' |title=Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. |journal=Brain Res. Mol. Brain Res. |volume=87 |issue= 2 |pages= 223-37 |year= 2001 |pmid= 11245925 |doi= }}
* {{cite journal | vauthors = Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA | title = Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 28 | pages = 21477–85 | date = Jul 2000 | pmid = 10748157 | doi = 10.1074/jbc.M909741199 }}
*{{cite journal | author=Duda DG, Sunamura M, Lozonschi L, ''et al.'' |title=Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. |journal=Br. J. Cancer |volume=86 |issue= 3 |pages= 490-6 |year= 2002 |pmid= 11875720 |doi= 10.1038/sj.bjc.6600067 }}
* {{cite journal | vauthors = Koh JT, Lee ZH, Ahn KY, Kim JK, Bae CS, Kim HH, Kee HJ, Kim KK | title = Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein | journal = Brain Research. Molecular Brain Research | volume = 87 | issue = 2 | pages = 223–37 | date = Mar 2001 | pmid = 11245925 | doi = 10.1016/S0169-328X(01)00004-3 }}
*{{cite journal | author=Lim IA, Hall DD, Hell JW |title=Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21697-711 |year= 2002 |pmid= 11937501 |doi= 10.1074/jbc.M112339200 }}
* {{cite journal | vauthors = Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S | title = Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis | journal = British Journal of Cancer | volume = 86 | issue = 3 | pages = 490–6 | date = Feb 2002 | pmid = 11875720 | pmc = 2375213 | doi = 10.1038/sj.bjc.6600067 }}
*{{cite journal | author=Mori K, Kanemura Y, Fujikawa H, ''et al.'' |title=Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. |journal=Neurosci. Res. |volume=43 |issue= 1 |pages= 69-74 |year= 2002 |pmid= 12074842 |doi= }}
* {{cite journal | vauthors = Lim IA, Hall DD, Hell JW | title = Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 24 | pages = 21697–711 | date = Jun 2002 | pmid = 11937501 | doi = 10.1074/jbc.M112339200 }}
*{{cite journal | author=Kaur B, Brat DJ, Calkins CC, Van Meir EG |title=Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. |journal=Am. J. Pathol. |volume=162 |issue= 1 |pages= 19-27 |year= 2003 |pmid= 12507886 |doi= }}
* {{cite journal | vauthors = Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I, Matsumoto T, Tamura K, Yokota M, Arita N | title = Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells | journal = Neuroscience Research | volume = 43 | issue = 1 | pages = 69–74 | date = May 2002 | pmid = 12074842 | doi = 10.1016/S0168-0102(02)00018-4 }}
*{{cite journal | author=Adkins JN, Varnum SM, Auberry KJ, ''et al.'' |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. |journal=Mol. Cell Proteomics |volume=1 |issue= 12 |pages= 947-55 |year= 2003 |pmid= 12543931 |doi= }}
* {{cite journal | vauthors = Kaur B, Brat DJ, Calkins CC, Van Meir EG | title = Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression | journal = The American Journal of Pathology | volume = 162 | issue = 1 | pages = 19–27 | date = Jan 2003 | pmid = 12507886 | pmc = 1851137 | doi = 10.1016/S0002-9440(10)63794-7 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG | title = Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 12 | pages = 947–55 | date = Dec 2002 | pmid = 12543931 | doi = 10.1074/mcp.M200066-MCP200 }}
*{{cite journal | author=Koh JT, Kook H, Kee HJ, ''et al.'' |title=Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. |journal=Exp. Cell Res. |volume=294 |issue= 1 |pages= 172-84 |year= 2004 |pmid= 14980512 |doi= 10.1016/j.yexcr.2003.11.008 }}
* {{cite journal | vauthors = Koh JT, Kook H, Kee HJ, Seo YW, Jeong BC, Lee JH, Kim MY, Yoon KC, Jung S, Kim KK | title = Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin | journal = Experimental Cell Research | volume = 294 | issue = 1 | pages = 172–84 | date = Mar 2004 | pmid = 14980512 | doi = 10.1016/j.yexcr.2003.11.008 }}
*{{cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
* {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = Jul 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}

Latest revision as of 08:41, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.[1][2] It is a member of the adhesion-GPCR family of receptors.[3]

Function

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.[2]

Interactions

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3[4] and MAGI1.[5]

Model organisms

Model organisms have been used in the study of BAI1 function. A conditional knockout mouse line called Bai1tm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12] - in-depth bone and cartilage phenotyping[13]



References

  1. ↑ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
  2. ↑ 2.0 2.1 "Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1".
  3. ↑ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
  4. ↑ Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Oct 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924.
  5. ↑ Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
  6. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  7. ↑ 7.0 7.1 "International Mouse Phenotyping Consortium".
  8. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  12. ↑ 12.0 12.1 "Infection and Immunity Immunophenotyping (3i) Consortium".
  13. ↑ 13.0 13.1 "OBCD Consortium".

External links

Further reading

  • Van Meir EG, Polverini PJ, Chazin VR, Su Huang HJ, de Tribolet N, Cavenee WK (Oct 1994). "Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells". Nature Genetics. 8 (2): 171–6. doi:10.1038/ng1094-171. PMID 7531056.
  • Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, Yoshida S, Ono M, Kuwano M, Nakamura Y, Tokino T (Oct 1997). "A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis". Oncogene. 15 (18): 2145–50. doi:10.1038/sj.onc.1201542. PMID 9393972.
  • Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T (Jun 1998). "Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 247 (3): 597–604. doi:10.1006/bbrc.1998.8603. PMID 9647739.
  • Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Ueyama Y, Tamaoki N, Nakamura M (Nov 1998). "Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer". International Journal of Oncology. 13 (5): 967–70. doi:10.3892/ijo.13.5.967. PMID 9772287.
  • Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y (Oct 1998). "Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1". Biochemical and Biophysical Research Communications. 251 (1): 158–65. doi:10.1006/bbrc.1998.9408. PMID 9790924.
  • Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, Nakamura Y, Tokino T (1999). "Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1". Cytogenetics and Cell Genetics. 84 (1–2): 75–82. doi:10.1159/000015219. PMID 10343108.
  • Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA (Jul 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". The Journal of Biological Chemistry. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157.
  • Koh JT, Lee ZH, Ahn KY, Kim JK, Bae CS, Kim HH, Kee HJ, Kim KK (Mar 2001). "Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein". Brain Research. Molecular Brain Research. 87 (2): 223–37. doi:10.1016/S0169-328X(01)00004-3. PMID 11245925.
  • Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S (Feb 2002). "Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis". British Journal of Cancer. 86 (3): 490–6. doi:10.1038/sj.bjc.6600067. PMC 2375213. PMID 11875720.
  • Lim IA, Hall DD, Hell JW (Jun 2002). "Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102". The Journal of Biological Chemistry. 277 (24): 21697–711. doi:10.1074/jbc.M112339200. PMID 11937501.
  • Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I, Matsumoto T, Tamura K, Yokota M, Arita N (May 2002). "Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells". Neuroscience Research. 43 (1): 69–74. doi:10.1016/S0168-0102(02)00018-4. PMID 12074842.
  • Kaur B, Brat DJ, Calkins CC, Van Meir EG (Jan 2003). "Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression". The American Journal of Pathology. 162 (1): 19–27. doi:10.1016/S0002-9440(10)63794-7. PMC 1851137. PMID 12507886.
  • Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG (Dec 2002). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Molecular & Cellular Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
  • Koh JT, Kook H, Kee HJ, Seo YW, Jeong BC, Lee JH, Kim MY, Yoon KC, Jung S, Kim KK (Mar 2004). "Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin". Experimental Cell Research. 294 (1): 172–84. doi:10.1016/j.yexcr.2003.11.008. PMID 14980512.
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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