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'''Latrophilins''' are a group of highly conserved [[G-protein coupled receptor]]s from the [[adhesion G protein-coupled receptor]] family. These receptors were originally identified based on their ability to bind the spider venom [[alpha-latrotoxin]].<ref name="pmid12196116">{{cite journal |vauthors=Kreienkamp HJ, Soltau M, Richter D, Böckers T | title = Interaction of G-protein-coupled receptors with synaptic scaffolding proteins | journal = Biochem. Soc. Trans. | volume = 30 | issue = 4 | pages = 464–8 | year = 2002 | pmid = 12196116 | doi = 10.1042/BST0300464| url = http://www.biochemsoctrans.org/bst/030/bst0300464.htm}}</ref> This conserved family of membrane proteins has up to three homologues in chordate species, including humans.<ref name="JPS">{{cite journal|last1=Silva|first1=JP|last2=Ushkaryov|first2=YA|title=The latrophilins, "split-personality" receptors.|journal=Advances in Experimental Medicine and Biology|date=2010|volume=706|pages=59–75|pmid=21618826|pmc=3145135}}</ref>
'''Latrophilins''' are a group of highly conserved [[G-protein coupled receptor]]s from the [[adhesion G protein-coupled receptor]] family. These receptors were originally identified based on their ability to bind the spider venom [[alpha-latrotoxin]].<ref name="pmid12196116">{{cite journal |vauthors=Kreienkamp HJ, Soltau M, Richter D, Böckers T | title = Interaction of G-protein-coupled receptors with synaptic scaffolding proteins | journal = Biochem. Soc. Trans. | volume = 30 | issue = 4 | pages = 464–8 | year = 2002 | pmid = 12196116 | doi = 10.1042/BST0300464| url = http://www.biochemsoctrans.org/bst/030/bst0300464.htm}}</ref> This conserved family of membrane proteins has up to three homologues in chordate species, including humans.<ref name="JPS">{{cite journal|last1=Silva|first1=JP|last2=Ushkaryov|first2=YA|title=The latrophilins, "split-personality" receptors.|journal=Advances in Experimental Medicine and Biology|date=2010|volume=706|pages=59–75|pmid=21618826|pmc=3145135|doi=10.1007/978-1-4419-7913-1_5}}</ref>


The precise functions of latrophilins remain unknown.<ref name="JPS" /> Genetic defects in latrophilin genes have been associated with diseases such as [[attention-deficit hyperactivity disorder]] and [[cancer]].<ref>{{cite journal|last1=Meza-Aguilar|first1=Diana G|last2=Boucard|first2=Antony A|title=Latrophilins updated|journal=Biomolecular Concepts|date=1 January 2014|volume=5|issue=6|doi=10.1515/bmc-2014-0032}}</ref>
The precise functions of latrophilins remain unknown.<ref name="JPS" /> Genetic defects in latrophilin genes have been associated with diseases such as [[attention-deficit hyperactivity disorder]] and [[cancer]].<ref>{{cite journal|last1=Meza-Aguilar|first1=Diana G|last2=Boucard|first2=Antony A|title=Latrophilins updated|journal=Biomolecular Concepts|date=1 January 2014|volume=5|issue=6|doi=10.1515/bmc-2014-0032}}</ref>

Latest revision as of 11:55, 10 January 2019

Latrophilin
Identifiers
SymbolLatrophilin
PfamPF02354
InterProIPR003334
EGF, latrophilin and seven transmembrane domain containing 1
Identifiers
SymbolELTD1
Alt. symbolsETL
Entrez64123
HUGO20822
RefSeqNM_022159
UniProtQ9HBW9
Other data
LocusChr. 1 p33-p32
latrophilin 1
Identifiers
SymbolLPHN1
Alt. symbolsKIAA0821, CIRL1, LEC2
Entrez22859
HUGO20973
RefSeqNM_014921
UniProtO94910
Other data
LocusChr. 19 p13.2
latrophilin 2
Identifiers
SymbolLPHN2
Alt. symbolsLPHH1, KIAA0786, LEC1
Entrez23266
HUGO18582
OMIM607018
RefSeqNM_012302
UniProtO95490
Other data
LocusChr. 1 p31.1
latrophilin 3
Identifiers
SymbolLPHN3
Alt. symbolsKIAA0768, LEC3
Entrez23284
HUGO20974
RefSeqNM_015236
UniProtQ9HAR2
Other data
LocusChr. 4 q13.1

Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind the spider venom alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]

The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]

Human proteins containing this domain

See also

References

  1. ↑ Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
  2. ↑ 2.0 2.1 Silva, JP; Ushkaryov, YA (2010). "The latrophilins, "split-personality" receptors". Advances in Experimental Medicine and Biology. 706: 59–75. doi:10.1007/978-1-4419-7913-1_5. PMC 3145135. PMID 21618826.
  3. ↑ Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6). doi:10.1515/bmc-2014-0032.
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