MRGPRX2: Difference between revisions

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{{Infobox_gene}}
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'''Mas-related G-protein coupled receptor member X2''' is a [[protein]] that in humans is encoded by the ''MRGPRX2'' [[gene]].<ref name="pmid11551509">{{cite journal |vauthors=Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ | title = A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons | journal = Cell | volume = 106 | issue = 5 | pages = 619–632 |date=Sep 2001 | pmid = 11551509 | pmc =  | doi =10.1016/S0092-8674(01)00483-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MRGPRX2 MAS-related GPR, member X2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117194| accessdate = }}</ref>
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Agonists are gyrase inhibitors like ciprofloxacine and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = MAS-related GPR, member X2
| HGNCid = 17983
| Symbol = MRGPRX2
| AltSymbols =; MRGX2
| OMIM = 607228
| ECnumber = 
| Homologene = 24986
| MGIid = 3588270
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0042923 |text = neuropeptide binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019233 |text = sensory perception of pain}} {{GNF_GO|id=GO:0030431 |text = sleep}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 117194
    | Hs_Ensembl = ENSG00000183695
    | Hs_RefseqProtein = NP_473371
    | Hs_RefseqmRNA = NM_054030
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 19032581
    | Hs_GenLoc_end = 19038804
    | Hs_Uniprot = Q96LB1
    | Mm_EntrezGene = 243978
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_001034868
    | Mm_RefseqProtein = NP_001030040
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start =   
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
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'''MAS-related GPR, member X2''', also known as '''MRGPRX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MRGPRX2 MAS-related GPR, member X2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117194| accessdate = }}</ref>
 
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Dong X, Han S, Zylka MJ, ''et al.'' |title=A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. |journal=Cell |volume=106 |issue= 5 |pages= 619-32 |year= 2001 |pmid= 11551509 |doi=  }}
*{{cite journal  | author=Takeda S |title=Identification of G protein-coupled receptor genes from the human genome sequence |journal=FEBS Lett. |volume=520 |issue= 1–3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=10.1016/S0014-5793(02)02775-8 |name-list-format=vanc| author2=Kadowaki S | author3=Haga T | display-authors=3 | last4=Takaesu  | first4=H  | last5=Mitaku  | first5=S }}
*{{cite journal  | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Robas N, Mead E, Fidock M |title=MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44400–44404 |year= 2004 |pmid= 12915402 |doi= 10.1074/jbc.M302456200 }}
*{{cite journal  | author=Robas N, Mead E, Fidock M |title=MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44400-4 |year= 2004 |pmid= 12915402 |doi= 10.1074/jbc.M302456200 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Yang S |title=Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception |journal=Gene |volume=352 |issue=  |pages= 30–35 |year= 2005 |pmid= 15862286 |doi= 10.1016/j.gene.2005.03.001 |name-list-format=vanc| author2=Liu Y  | author3=Lin AA  | display-authors=3  | last4=Cavalli-Sforza  | first4=L. Luca  | last5=Zhao  | first5=Zhongming  | last6=Su  | first6=Bing }}
*{{cite journal  | author=Yang S, Liu Y, Lin AA, ''et al.'' |title=Adaptive evolution of MRGX2, a human sensory neuron specific gene involved in nociception. |journal=Gene |volume=352 |issue=  |pages= 30-5 |year= 2005 |pmid= 15862286 |doi= 10.1016/j.gene.2005.03.001 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
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[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mas-related G-protein coupled receptor member X2 is a protein that in humans is encoded by the MRGPRX2 gene.[1][2] Agonists are gyrase inhibitors like ciprofloxacine and non-steroidal neuromuscular blocking agents like atracurium as well as vancomycin. Activation of MRGPRX2 leads to mast cell degranulation with subsequent pseudo-allergic reactions.


See also

References

  1. ↑ Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001). "A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons". Cell. 106 (5): 619–632. doi:10.1016/S0092-8674(01)00483-4. PMID 11551509.
  2. ↑ "Entrez Gene: MRGPRX2 MAS-related GPR, member X2".

Further reading

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