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{{Infobox_gene}}
'''EGF-like module-containing mucin-like hormone receptor-like 3''' is a [[protein]] encoded by the ''ADGRE3'' [[gene]].<ref name="pmid11279179">{{cite journal | vauthors = Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ | title = Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18863–70 | date = Jun 2001 | pmid = 11279179 | pmc =  | doi = 10.1074/jbc.M101147200 }}</ref><ref>{{cite journal|last1=Hamann|first1=J|last2=Aust|first2=G|last3=Araç|first3=D|last4=Engel|first4=FB|last5=Formstone|first5=C|last6=Fredriksson|first6=R|last7=Hall|first7=RA|last8=Harty|first8=BL|last9=Kirchhoff|first9=C|last10=Knapp|first10=B|last11=Krishnan|first11=A|last12=Liebscher|first12=I|last13=Lin|first13=HH|last14=Martinelli|first14=DC|last15=Monk|first15=KR|last16=Peeters|first16=MC|last17=Piao|first17=X|last18=Prömel|first18=S|last19=Schöneberg|first19=T|last20=Schwartz|first20=TW|last21=Singer|first21=K|last22=Stacey|first22=M|last23=Ushkaryov|first23=YA|last24=Vallon|first24=M|last25=Wolfrum|first25=U|last26=Wright|first26=MW|last27=Xu|first27=L|last28=Langenhan|first28=T|last29=Schiöth|first29=HB|title=International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.|journal=Pharmacological Reviews|date=April 2015|volume=67|issue=2|pages=338–67|pmid=25713288|doi=10.1124/pr.114.009647|pmc=4394687}}</ref> EMR3 is a member of the [[adhesion-GPCRs|adhesion GPCR]] family.<ref name="isbn1-4419-7912-3">{{cite book | author = Stacey M, Yona S | title = Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 1-4419-7912-3 }}</ref><ref>{{cite journal|last1=Langenhan|first1=T|last2=Aust|first2=G|last3=Hamann|first3=J|title=Sticky signaling--adhesion class G protein-coupled receptors take the stage.|journal=Science Signaling|date=21 May 2013|volume=6|issue=276|pages=re3|pmid=23695165|doi=10.1126/scisignal.2003825}}</ref>
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing [[GAIN domain|(GAIN)]] domain.<ref name="pmid22333914">{{cite journal | vauthors = Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = The EMBO Journal | volume = 31 | issue = 6 | pages = 1364–78 | date = Mar 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }}</ref>


EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.<ref>{{cite journal | vauthors = Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J | title = The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes | journal = Journal of Leukocyte Biology | volume = 81 | issue = 2 | pages = 440–8 | date = Feb 2007 | pmid = 17108056 | doi = 10.1189/jlb.0406276 }}</ref> Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.<ref name="ReferenceA">{{cite journal | vauthors = Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ | title = Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18863–70 | date = Jun 2001 | pmid = 11279179 | doi = 10.1074/jbc.M101147200 }}</ref> Mice, next to Emr2, lack the Emr3 gene.<ref>{{cite journal | vauthors = Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J | title = An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2 | journal = FASEB Journal | volume = 20 | issue = 14 | pages = 2582–4 | date = Dec 2006 | pmid = 17068111 | doi = 10.1096/fj.06-6500fje }}</ref>


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
== Function ==
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein may play a role in [[myeloid]]-myeloid interactions during immune and inflammatory responses.<ref name="entrez">{{cite web | title = Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658| accessdate = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Egf-like module containing, mucin-like, hormone receptor-like 3
| HGNCid = 23647
| Symbol = EMR3
| AltSymbols =;
| OMIM = 606101
| ECnumber = 
| Homologene = 50009
| MGIid = 
| GeneAtlas_image1 = PBB_GE_EMR3_210724_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 84658
    | Hs_Ensembl = ENSG00000131355
    | Hs_RefseqProtein = NP_115960
    | Hs_RefseqmRNA = NM_032571
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 14570918
    | Hs_GenLoc_end = 14646810
    | Hs_Uniprot = Q9BY15
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Egf-like module containing, mucin-like, hormone receptor-like 3''', also known as '''EMR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Ligands ==
{{PBB_Summary
A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.<ref name="ReferenceA"/>
| section_title =  
| summary_text = This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.<ref name="entrez">{{cite web | title = Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658| accessdate = }}</ref>
}}


==See also==
== References ==
* [[EGF module-containing mucin-like hormone receptor]]
{{reflist}}


==References==
== External links ==
{{reflist|2}}
* [http://www.adhesiongpcr.org/Adhesion GPCR consortium]


==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Stacey M, Lin HH, Hilyard KL, ''et al.'' |title=Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 18863-70 |year= 2001 |pmid= 11279179 |doi= 10.1074/jbc.M101147200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Matmati M, Pouwels W, van Bruggen R, ''et al.'' |title=The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. |journal=J. Leukoc. Biol. |volume=81 |issue= 2 |pages= 440-8 |year= 2007 |pmid= 17108056 |doi= 10.1189/jlb.0406276 }}
}}
{{refend}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}

Latest revision as of 23:44, 15 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene.[1][2] EMR3 is a member of the adhesion GPCR family.[3][4] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[5]

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[6] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[7] Mice, next to Emr2, lack the Emr3 gene.[8]

Function

The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.[9]

Ligands

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[7]

References

  1. ↑ Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179.
  2. ↑ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  3. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
  4. ↑ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165.
  5. ↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  6. ↑ Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J (Feb 2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes". Journal of Leukocyte Biology. 81 (2): 440–8. doi:10.1189/jlb.0406276. PMID 17108056.
  7. ↑ 7.0 7.1 Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". The Journal of Biological Chemistry. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179.
  8. ↑ Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (Dec 2006). "An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2". FASEB Journal. 20 (14): 2582–4. doi:10.1096/fj.06-6500fje. PMID 17068111.
  9. ↑ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3".

External links

Retrieved from "https://www.wikidoc.org/index.php?title=EMR3&oldid=1529710"