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{{Infobox_gene}}
{{PBB_Controls
'''C5a anaphylatoxin chemotactic receptor C5a2''' also known as '''C5L2, G protein-coupled receptor 77''', is a [[protein]] that in humans is encoded by the ''C5AR2'' [[gene]].<ref name="pmid11165367">{{cite journal |vauthors=Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF | title = Identification of four novel human G protein-coupled receptors expressed in the brain | journal = Brain Res Mol Brain Res | volume = 86 | issue = 1–2 | pages = 13–22 |date=Feb 2001 | pmid = 11165367 | pmc = | doi =10.1016/S0169-328X(00)00242-4  }}</ref><ref name="HUGO"/>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 77
| HGNCid = 4527
| Symbol = GPR77
| AltSymbols =; C5L2; GPF77
| OMIM = 609949
| ECnumber = 
| Homologene = 49549
| MGIid = 2442013
| GeneAtlas_image1 = PBB_GE_GPR77_221149_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004944 |text = C5a anaphylatoxin receptor activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27202
    | Hs_Ensembl = ENSG00000134830
    | Hs_RefseqProtein = NP_060955
    | Hs_RefseqmRNA = NM_018485
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 52535880
    | Hs_GenLoc_end = 52537112
    | Hs_Uniprot = Q9P296
    | Mm_EntrezGene = 319430
    | Mm_Ensembl = ENSMUSG00000074361
    | Mm_RefseqmRNA = NM_176912
    | Mm_RefseqProtein = NP_795886
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 15395446
    | Mm_GenLoc_end = 15400840
    | Mm_Uniprot = 
  }}
}}
'''G protein-coupled receptor 77''', also known as '''GPR77''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR77 G protein-coupled receptor 77| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27202| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[anaphylatoxin]]s C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate [[complement activation]], anaphylatoxins may be involved in [[autoimmunity]] and [[sepsis]]. C5a2 is coexpressed with the [[C5a receptor]], (C5a1, C5aR, C5R1, CD88), on polymorphonuclear [[neutrophil]]s and may modulate C5a1 activity.<ref name="HUGO">{{cite web | title = HUGO| url = https://www.genenames.org/data/hgnc_data.php?hgnc_id=4527| accessdate = }}</ref><ref name="pmid16204243">{{cite journal |vauthors=Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C | title = An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2 | journal = J. Biol. Chem. | volume = 280 | issue = 48 | pages = 39677–80 |date=December 2005 | pmid = 16204243 | doi = 10.1074/jbc.C500287200 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GPR77 G protein-coupled receptor 77| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27202| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Klos A, Wende E, Wareham KJ, Monk PN |title=International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors |journal=Pharmacol. Rev. |volume=65 |issue= 1 |pages= 500–43 |year= 2013 |pmid= 23383423 |doi=10.1124/pr.111.005223}}
| citations =
*{{cite journal   |vauthors=Ohno M, Hirata T, Enomoto M, etal |title=A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells |journal=Mol. Immunol. |volume=37 |issue= 8 |pages= 407–12 |year= 2000 |pmid= 11090875 |doi=10.1016/S0161-5890(00)00067-5 }}
*{{cite journal  | author=Ohno M, Hirata T, Enomoto M, ''et al.'' |title=A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. |journal=Mol. Immunol. |volume=37 |issue= 8 |pages= 407-12 |year= 2000 |pmid= 11090875 |doi= }}
*{{cite journal  |vauthors=Cain SA, Monk PN |title=The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74) |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7165–9 |year= 2002 |pmid= 11773063 |doi= 10.1074/jbc.C100714200 }}
*{{cite journal | author=Lee DK, George SR, Cheng R, ''et al.'' |title=Identification of four novel human G protein-coupled receptors expressed in the brain. |journal=Brain Res. Mol. Brain Res. |volume=86 |issue= 1-2 |pages= 13-22 |year= 2001 |pmid= 11165367 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Cain SA, Monk PN |title=The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7165-9 |year= 2002 |pmid= 11773063 |doi= 10.1074/jbc.C100714200 }}
*{{cite journal   |vauthors=Kalant D, Cain SA, Maslowska M, etal |title=The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11123–9 |year= 2003 |pmid= 12540846 |doi= 10.1074/jbc.M206169200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Otto M, Hawlisch H, Monk PN, etal |title=C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 142–51 |year= 2004 |pmid= 14570896 |doi= 10.1074/jbc.M310078200 }}
*{{cite journal | author=Kalant D, Cain SA, Maslowska M, ''et al.'' |title=The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11123-9 |year= 2003 |pmid= 12540846 |doi= 10.1074/jbc.M206169200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Otto M, Hawlisch H, Monk PN, ''et al.'' |title=C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 142-51 |year= 2004 |pmid= 14570896 |doi= 10.1074/jbc.M310078200 }}
*{{cite journal   |vauthors=Huber-Lang M, Sarma JV, Rittirsch D, etal |title=Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans |journal=J. Immunol. |volume=174 |issue= 2 |pages= 1104–10 |year= 2005 |pmid= 15634936 |doi=  10.4049/jimmunol.174.2.1104}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kalant D, MacLaren R, Cui W, etal |title=C5L2 is a functional receptor for acylation-stimulating protein |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23936–44 |year= 2005 |pmid= 15833747 |doi= 10.1074/jbc.M406921200 }}
*{{cite journal | author=Huber-Lang M, Sarma JV, Rittirsch D, ''et al.'' |title=Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. |journal=J. Immunol. |volume=174 |issue= 2 |pages= 1104-10 |year= 2005 |pmid= 15634936 |doi=  }}
*{{cite journal   |vauthors=Johswich K, Martin M, Thalmann J, etal |title=Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39088–95 |year= 2007 |pmid= 17068344 |doi= 10.1074/jbc.M609734200 }}
*{{cite journal | author=Kalant D, MacLaren R, Cui W, ''et al.'' |title=C5L2 is a functional receptor for acylation-stimulating protein. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23936-44 |year= 2005 |pmid= 15833747 |doi= 10.1074/jbc.M406921200 }}
*{{cite journal   |vauthors=Scola AM, Higginbottom A, Partridge LJ, etal |title=THE ROLE OF THE N-TERMINAL DOMAIN OF THE COMPLEMENT FRAGMENT RECEPTOR, C5L2, IN LIGAND BINDING |journal=J. Biol. Chem. |volume=282 |issue= 6 |pages= 3664–71 |year= 2007 |pmid= 17158873 |doi= 10.1074/jbc.M609178200 | pmc=2873560 }}
*{{cite journal | author=Johswich K, Martin M, Thalmann J, ''et al.'' |title=Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39088-95 |year= 2007 |pmid= 17068344 |doi= 10.1074/jbc.M609734200 }}
*{{cite journal | author=Scola AM, Higginbottom A, Partridge LJ, ''et al.'' |title=The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. |journal=J. Biol. Chem. |volume=282 |issue= 6 |pages= 3664-71 |year= 2007 |pmid= 17158873 |doi= 10.1074/jbc.M609178200 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
==External links==
* {{cite web | url = http://www.iuphar-db.org/DATABASE/ObjectDisplayForward?objectId=33&familyId=5 | title = Complement Peptide Receptors: C5a2  | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
 
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a protein that in humans is encoded by the C5AR2 gene.[1][2]

Function

The anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5a2 is coexpressed with the C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear neutrophils and may modulate C5a1 activity.[2][3]

References

  1. ↑ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
  2. ↑ 2.0 2.1 "HUGO".
  3. ↑ Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C (December 2005). "An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2". J. Biol. Chem. 280 (48): 39677–80. doi:10.1074/jbc.C500287200. PMID 16204243.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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