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{{Infobox_gene}}
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'''G protein-coupled receptor 1''', also known as '''GPR1''', is a [[protein]] that in humans is encoded by the ''GPR1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR1 G protein-coupled receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2825| accessdate = }}</ref><ref name="pmid7851889">{{cite journal |vauthors=Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF | title = Cloning of human genes encoding novel G protein-coupled receptors | journal = Genomics | volume = 23 | issue = 3 | pages = 609–18 |date=October 1994 | pmid = 7851889 | doi = 10.1006/geno.1994.1549 | url = }}</ref>
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GPR1 is a member of the [[G protein-coupled receptor]] family of transmembrane receptors.  It functions as a receptor for [[chemerin]].<ref name="pmid18165312">{{cite journal |vauthors=Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ | title = The genetic design of signaling cascades to record receptor activation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 1 | pages = 64–9 |date=January 2008 | pmid = 18165312 | pmc = 2224232 | doi = 10.1073/pnas.0710487105 | url = }}</ref> Other receptors for chemerin include [[CMKLR1]] and [[CCRL2]].
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 1
| HGNCid = 4463
| Symbol = GPR1
| AltSymbols =;
| OMIM = 600239
| ECnumber = 
| Homologene = 21094
| MGIid = 2385324
| GeneAtlas_image1 = PBB_GE_GPR1_214605_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2825
    | Hs_Ensembl = ENSG00000183671
    | Hs_RefseqProtein = NP_005270
    | Hs_RefseqmRNA = NM_005279
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 206748289
    | Hs_GenLoc_end = 206790880
    | Hs_Uniprot = P46091
    | Mm_EntrezGene = 241070
    | Mm_Ensembl = ENSMUSG00000046856
    | Mm_RefseqmRNA = NM_146250
    | Mm_RefseqProtein = NP_666362
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 63116967
    | Mm_GenLoc_end = 63148485
    | Mm_Uniprot = Q8K087
  }}
}}
'''G protein-coupled receptor 1''', also known as '''GPR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR1 G protein-coupled receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2825| accessdate = }}</ref>


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==References==
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{{reflist}}
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==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Marchese A, Docherty JM, Nguyen T, ''et al.'' |title=Cloning of human genes encoding novel G protein-coupled receptors. |journal=Genomics |volume=23 |issue= 3 |pages= 609-18 |year= 1995 |pmid= 7851889 |doi= 10.1006/geno.1994.1549 }}
*{{cite journal  | author=Shimizu N |title=An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived Cells |journal=J. Virol. |volume=73 |issue= 6 |pages= 5231–9 |year= 1999 |pmid= 10233994 |doi=  | pmc=112576  |name-list-format=vanc| author2=Soda Y | author3=Kanbe K | display-authors=3  | last4=Liu  | first4=HY  | last5=Jinno  | first5=A  | last6=Kitamura  | first6=T  | last7=Hoshino  | first7=H }}
*{{cite journal | author=Shimizu N, Soda Y, Kanbe K, ''et al.'' |title=An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. |journal=J. Virol. |volume=73 |issue= 6 |pages= 5231-9 |year= 1999 |pmid= 10233994 |doi=  }}
*{{cite journal  | author=Tokizawa S |title=Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor |journal=Kidney Int. |volume=58 |issue= 2 |pages= 607–17 |year= 2000 |pmid= 10916084 |doi= 10.1046/j.1523-1755.2000.00207.x |name-list-format=vanc| author2=Shimizu N  | author3=Hui-Yu L  | display-authors=3  | last4=Deyu  | first4=Fang  | last5=Haraguchi  | first5=Yuji  | last6=Oite  | first6=Takashi  | last7=Hoshino  | first7=Hiroo }}
*{{cite journal  | author=Tokizawa S, Shimizu N, Hui-Yu L, ''et al.'' |title=Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor. |journal=Kidney Int. |volume=58 |issue= 2 |pages= 607-17 |year= 2000 |pmid= 10916084 |doi= 10.1046/j.1523-1755.2000.00207.x }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kang MK |title=Senescence-associated genes in normal human oral keratinocytes |journal=Exp. Cell Res. |volume=287 |issue= 2 |pages= 272–81 |year= 2003 |pmid= 12837283 |doi=10.1016/S0014-4827(03)00061-2  |name-list-format=vanc| author2=Kameta A  | author3=Shin KH  | display-authors=3  | last4=Baluda  | first4=MA  | last5=Kim  | first5=HR  | last6=Park  | first6=NH }}
*{{cite journal  | author=Kang MK, Kameta A, Shin KH, ''et al.'' |title=Senescence-associated genes in normal human oral keratinocytes. |journal=Exp. Cell Res. |volume=287 |issue= 2 |pages= 272-81 |year= 2003 |pmid= 12837283 |doi=  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillier LW |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |name-list-format=vanc| author2=Graves TA  | author3=Fulton RS  | display-authors=3  | last4=Fulton  | first4=Lucinda A.  | last5=Pepin  | first5=Kymberlie H.  | last6=Minx  | first6=Patrick  | last7=Wagner-Mcpherson  | first7=Caryn  | last8=Layman  | first8=Dan  | last9=Wylie  | first9=Kristine }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Jinno-Oue A |title=The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1 |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 30924–34 |year= 2005 |pmid= 15919664 |doi= 10.1074/jbc.M500195200 |name-list-format=vanc| author2=Shimizu N  | author3=Soda Y  | display-authors=3  | last4=Tanaka  | first4=A  | last5=Ohtsuki  | first5=T  | last6=Kurosaki  | first6=D  | last7=Suzuki  | first7=Y  | last8=Hoshino  | first8=H }}
*{{cite journal  | author=Jinno-Oue A, Shimizu N, Soda Y, ''et al.'' |title=The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1. |journal=J. Biol. Chem. |volume=280 |issue= 35 |pages= 30924-34 |year= 2005 |pmid= 15919664 |doi= 10.1074/jbc.M500195200 }}
*{{cite journal  | author=Otsuki T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |name-list-format=vanc| author2=Ota T  | author3=Nishikawa T  | display-authors=3  | last4=Hayashi  | first4=K  | last5=Suzuki  | first5=Y  | last6=Yamamoto  | first6=J  | last7=Wakamatsu  | first7=A  | last8=Kimura  | first8=K  | last9=Sakamoto  | first9=K }}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
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[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene.[1][2]

GPR1 is a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin.[3] Other receptors for chemerin include CMKLR1 and CCRL2.

References

  1. ↑ "Entrez Gene: GPR1 G protein-coupled receptor 1".
  2. ↑ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
  3. ↑ Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ (January 2008). "The genetic design of signaling cascades to record receptor activation". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 64–9. doi:10.1073/pnas.0710487105. PMC 2224232. PMID 18165312.

Further reading

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