GPR156: Difference between revisions

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{{Infobox_gene}}
'''GPR156''' (G protein-coupled receptor 156), is a human [[gene]] which encodes a [[G protein-coupled receptor]] belonging to [[Class C GPCR|metabotropic glutamate receptor]] subfamily.<ref name="entrez">{{cite web | title = Entrez Gene: GPR156 G protein-coupled receptor 156| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=165829| accessdate = }}</ref>  By sequence homology, this gene was proposed as being a possible [[GABAB receptor|GABA<sub>B</sub> receptor]] subunit, however when expressed in cells alone or with other GABA<sub>B</sub> subunits, no response to GABA<sub>B</sub> ligands could be detected.  Therefore, the function of this protein remains to be elucidated.<ref name="pmid12591167">{{cite journal |vauthors=Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN | title = Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor | journal = Brain Res. Mol. Brain Res. | volume = 110 | issue = 2 | pages = 305–17 | year = 2003 | pmid = 12591167 | doi = 10.1016/S0169-328X(02)00662-9 }}</ref>


==References==
{{reflist}}


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| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 156
| HGNCid = 20844
| Symbol = GPR156
| AltSymbols =; GABABL; MGC142261; PGR28
| OMIM = 610464
| ECnumber = 
| Homologene = 17683
| MGIid = 2653880
| GeneAtlas_image1 = PBB_GE_GPR156_gnf1h10156_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPR156_gnf1h10157_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004965 |text = GABA-B receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 165829
    | Hs_Ensembl = ENSG00000175697
    | Hs_RefseqProtein = NP_694547
    | Hs_RefseqmRNA = NM_153002
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 121362775
    | Hs_GenLoc_end = 121445657
    | Hs_Uniprot = Q8NFN8
    | Mm_EntrezGene = 239845
    | Mm_Ensembl = ENSMUSG00000046961
    | Mm_RefseqmRNA = NM_153394
    | Mm_RefseqProtein = NP_700443
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 37835735
    | Mm_GenLoc_end = 37926772
    | Mm_Uniprot = Q6PCP7
  }}
}}
'''GPR156''' (G protein-coupled receptor 156), is a human [[gene]] which encodes a [[G protein-coupled receptor]] belonging to [[Class C GPCR|metabotropic glutamate receptor]] subfamily.<ref name="entrez">{{cite web | title = Entrez Gene: GPR156 G protein-coupled receptor 156| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=165829| accessdate = }}</ref>  By sequence homology, this gene was proposed as being a possible [[GABAB receptor|GABA<sub>B</sub> receptor]] subunit, however when expressed in cells alone or with other GABA<sub>B</sub> subunits, no response to GABA<sub>B</sub> ligands could be detected.  Therefore the function of this protein remains to be elucidated.<ref name="pmid12591167">{{cite journal | author = Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN | title = Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor | journal = Brain Res. Mol. Brain Res. | volume = 110 | issue = 2 | pages = 305–17 | year = 2003 | pmid = 12591167 | doi = 10.1016/S0169-328X(02)00662-9 | issn = }}</ref>
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| summary_text =
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==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin}}
{{PBB_Further_reading
*{{cite journal |vauthors=Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN | title = Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor. | journal = Brain Res. Mol. Brain Res. | volume = 110 | issue = 2 | pages = 305–17 | year = 2003 | pmid = 12591167 | doi = 10.1016/S0169-328X(02)00662-9 }}
| citations =
*{{cite journal |vauthors=Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA | title = The G protein-coupled receptor repertoires of human and mouse. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 8 | pages = 4903–8 | year = 2003 | pmid = 12679517 | pmc = 153653 | doi = 10.1073/pnas.0230374100 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Calver AR, Michalovich D, Testa TT, ''et al.'' |title=Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor. |journal=Brain Res. Mol. Brain Res. |volume=110 |issue= 2 |pages= 305-17 |year= 2003 |pmid= 12591167 |doi= }}
*{{cite journal | author=Vassilatis DK, Hohmann JG, Zeng H, ''et al.'' |title=The G protein-coupled receptor repertoires of human and mouse. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4903-8 |year= 2003 |pmid= 12679517 |doi= 10.1073/pnas.0230374100 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


{{G protein-coupled receptors}}
{{G protein-coupled receptors|g3}}
[[Category:G protein coupled receptors]]


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 23:31, 19 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

GPR156 (G protein-coupled receptor 156), is a human gene which encodes a G protein-coupled receptor belonging to metabotropic glutamate receptor subfamily.[1] By sequence homology, this gene was proposed as being a possible GABAB receptor subunit, however when expressed in cells alone or with other GABAB subunits, no response to GABAB ligands could be detected. Therefore, the function of this protein remains to be elucidated.[2]

References

  1. ↑ "Entrez Gene: GPR156 G protein-coupled receptor 156".
  2. ↑ Calver AR, Michalovich D, Testa TT, Robbins MJ, Jaillard C, Hill J, Szekeres PG, Charles KJ, Jourdain S, Holbrook JD, Boyfield I, Patel N, Medhurst AD, Pangalos MN (2003). "Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor". Brain Res. Mol. Brain Res. 110 (2): 305–17. doi:10.1016/S0169-328X(02)00662-9. PMID 12591167.

Further reading

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