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{{Infobox_gene}}
{{PBB_Controls
'''MAS proto-oncogene''', or '''MAS1 proto-oncogene, G protein-coupled receptor''' ('''MRGA'',''MAS'',''MGRA""), is a [[protein]] that in humans is encoded by the ''MAS1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAS1 MAS1 oncogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4142| accessdate = }}</ref>
| update_page = yes
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}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = MAS1 oncogene
| HGNCid = 6899
| Symbol = MAS1
| AltSymbols =; MAS; MGC119966
| OMIM = 165180
| ECnumber = 
| Homologene = 1782
| MGIid = 96918
| GeneAtlas_image1 = PBB_GE_MAS1_208210_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004945 |text = angiotensin type II receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4142
    | Hs_Ensembl = ENSG00000130368
    | Hs_RefseqProtein = NP_002368
    | Hs_RefseqmRNA = NM_002377
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 160247712
    | Hs_GenLoc_end = 160249098
    | Hs_Uniprot = P04201
    | Mm_EntrezGene = 17171
    | Mm_Ensembl = ENSMUSG00000068037
    | Mm_RefseqmRNA = XM_622557
    | Mm_RefseqProtein = XP_622557
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 12684492
    | Mm_GenLoc_end = 12685466
    | Mm_Uniprot = Q0VB49
  }}
}}
'''MAS1 oncogene''', also known as '''MAS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAS1 MAS1 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4142| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.<ref name="entrez">{{cite web | title = Entrez Gene: MAS1 MAS1 oncogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4142| accessdate = }}</ref>
| summary_text = The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.<ref name="entrez" />
}}
}}
[[Agonist]]s of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).
Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)). 


==See also==
==See also==
Line 58: Line 16:


==References==
==References==
{{reflist|2}}
{{Reflist|2}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hanley MR | title = Molecular and cell biology of angiotensin receptors | journal = Journal of Cardiovascular Pharmacology | volume = 18 Suppl 2 | issue =  | pages = S7-13 | year = 1992 | pmid = 1725048 | doi =  10.1097/00005344-199106182-00003}}
| citations =
* {{cite journal | vauthors = Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M | title = The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action | journal = Ciba Foundation Symposium | volume = 150 | issue =  | pages = 23–38; discussion 38–46 | year = 1990 | pmid = 2197067 | doi =  }}
*{{cite journal | author=Hanley MR |title=Molecular and cell biology of angiotensin receptors. |journal=J. Cardiovasc. Pharmacol. |volume=18 Suppl 2 |issue=  |pages= S7-13 |year= 1992 |pmid= 1725048 |doi=  }}
* {{cite journal | vauthors = Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH | title = Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements | journal = Oncogene Research | volume = 1 | issue = 2 | pages = 169–78 | date = Jul 1987 | pmid = 3329713 | doi =  }}
*{{cite journal | author=Hanley MR, Cheung WT, Hawkins P, ''et al.'' |title=The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action. |journal=Ciba Found. Symp. |volume=150 |issue=  |pages= 23-38; discussion 38-46 |year= 1990 |pmid= 2197067 |doi=  }}
* {{cite journal | vauthors = Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR | title = The mas oncogene encodes an angiotensin receptor | journal = Nature | volume = 335 | issue = 6189 | pages = 437–40 | date = Sep 1988 | pmid = 3419518 | doi = 10.1038/335437a0 }}
*{{cite journal | author=Rabin M, Birnbaum D, Young D, ''et al.'' |title=Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. |journal=Oncogene Res. |volume=1 |issue= 2 |pages= 169-78 |year= 1988 |pmid= 3329713 |doi=  }}
* {{cite journal | vauthors = Young D, Waitches G, Birchmeier C, Fasano O, Wigler M | title = Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains | journal = Cell | volume = 45 | issue = 5 | pages = 711–9 | date = Jun 1986 | pmid = 3708691 | doi = 10.1016/0092-8674(86)90785-3 }}
*{{cite journal | author=Jackson TR, Blair LA, Marshall J, ''et al.'' |title=The mas oncogene encodes an angiotensin receptor. |journal=Nature |volume=335 |issue= 6189 |pages= 437-40 |year= 1988 |pmid= 3419518 |doi= 10.1038/335437a0 }}
* {{cite journal | vauthors = Riesewijk AM, Schepens MT, Mariman EM, Ropers HH, Kalscheuer VM | title = The MAS proto-oncogene is not imprinted in humans | journal = Genomics | volume = 35 | issue = 2 | pages = 380–2 | date = Jul 1996 | pmid = 8661154 | doi = 10.1006/geno.1996.0372 }}
*{{cite journal | author=Young D, Waitches G, Birchmeier C, ''et al.'' |title=Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. |journal=Cell |volume=45 |issue= 5 |pages= 711-9 |year= 1986 |pmid= 3708691 |doi= }}
* {{cite journal | vauthors = Xu X, Quiambao AB, Roveri L, Pardue MT, Marx JL, Röhlich P, Peachey NS, Al-Ubaidi MR | title = Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene | journal = Experimental Neurology | volume = 163 | issue = 1 | pages = 207–19 | date = May 2000 | pmid = 10785460 | doi = 10.1006/exnr.2000.7370 }}
*{{cite journal | author=Riesewijk AM, Schepens MT, Mariman EM, ''et al.'' |title=The MAS proto-oncogene is not imprinted in humans. |journal=Genomics |volume=35 |issue= 2 |pages= 380-2 |year= 1996 |pmid= 8661154 |doi= 10.1006/geno.1996.0372 }}
* {{cite journal | vauthors = Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T | title = Cell type-specific expression of the Mas proto-oncogene in testis | journal = The Journal of Histochemistry and Cytochemistry | volume = 50 | issue = 5 | pages = 691–6 | date = May 2002 | pmid = 11967280 | doi = 10.1177/002215540205000510 }}
*{{cite journal | author=Xu X, Quiambao AB, Roveri L, ''et al.'' |title=Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene. |journal=Exp. Neurol. |volume=163 |issue= 1 |pages= 207-19 |year= 2000 |pmid= 10785460 |doi= 10.1006/exnr.2000.7370 }}
* {{cite journal | vauthors = Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T | title = Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 14 | pages = 8258–63 | date = Jul 2003 | pmid = 12829792 | pmc = 166216 | doi = 10.1073/pnas.1432869100 }}
*{{cite journal | author=Alenina N, Baranova T, Smirnow E, ''et al.'' |title=Cell type-specific expression of the Mas proto-oncogene in testis. |journal=J. Histochem. Cytochem. |volume=50 |issue= 5 |pages= 691-6 |year= 2002 |pmid= 11967280 |doi=  }}
* {{cite journal | vauthors = Canals M, Jenkins L, Kellett E, Milligan G | title = Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS | journal = The Journal of Biological Chemistry | volume = 281 | issue = 24 | pages = 16757–67 | date = Jun 2006 | pmid = 16611642 | doi = 10.1074/jbc.M601121200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Santos RA, Simoes e Silva AC, Maric C, ''et al.'' |title=Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8258-63 |year= 2003 |pmid= 12829792 |doi= 10.1073/pnas.1432869100 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Canals M, Jenkins L, Kellett E, Milligan G |title=Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS. |journal=J. Biol. Chem. |volume=281 |issue= 24 |pages= 16757-67 |year= 2006 |pmid= 16611642 |doi= 10.1074/jbc.M601121200 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:01, 24 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA,MAS,MGRA""), is a protein that in humans is encoded by the MAS1 gene.[1]

The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.[1]

Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).

Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: MAS1 MAS1 oncogene".

Further reading

  • Hanley MR (1992). "Molecular and cell biology of angiotensin receptors". Journal of Cardiovascular Pharmacology. 18 Suppl 2: S7–13. doi:10.1097/00005344-199106182-00003. PMID 1725048.
  • Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M (1990). "The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action". Ciba Foundation Symposium. 150: 23–38, discussion 38–46. PMID 2197067.
  • Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH (Jul 1987). "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Research. 1 (2): 169–78. PMID 3329713.
  • Jackson TR, Blair LA, Marshall J, Goedert M, Hanley MR (Sep 1988). "The mas oncogene encodes an angiotensin receptor". Nature. 335 (6189): 437–40. doi:10.1038/335437a0. PMID 3419518.
  • Young D, Waitches G, Birchmeier C, Fasano O, Wigler M (Jun 1986). "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell. 45 (5): 711–9. doi:10.1016/0092-8674(86)90785-3. PMID 3708691.
  • Riesewijk AM, Schepens MT, Mariman EM, Ropers HH, Kalscheuer VM (Jul 1996). "The MAS proto-oncogene is not imprinted in humans". Genomics. 35 (2): 380–2. doi:10.1006/geno.1996.0372. PMID 8661154.
  • Xu X, Quiambao AB, Roveri L, Pardue MT, Marx JL, Röhlich P, Peachey NS, Al-Ubaidi MR (May 2000). "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Experimental Neurology. 163 (1): 207–19. doi:10.1006/exnr.2000.7370. PMID 10785460.
  • Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, Walther T (May 2002). "Cell type-specific expression of the Mas proto-oncogene in testis". The Journal of Histochemistry and Cytochemistry. 50 (5): 691–6. doi:10.1177/002215540205000510. PMID 11967280.
  • Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T (Jul 2003). "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8258–63. doi:10.1073/pnas.1432869100. PMC 166216. PMID 12829792.
  • Canals M, Jenkins L, Kellett E, Milligan G (Jun 2006). "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". The Journal of Biological Chemistry. 281 (24): 16757–67. doi:10.1074/jbc.M601121200. PMID 16611642.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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