GABBR1: Difference between revisions

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{{Infobox_gene}}
'''Gamma-aminobutyric acid (GABA) B receptor, 1''' ('''GABA<sub>B1</sub>'''), is a [[G-protein coupled receptor]] subunit encoded by the '''GABBR1''' [[gene]].


== Function ==


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system.  GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region.  Alternative splicing of this gene generates 4 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2550| accessdate = }}</ref>
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_GABBR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1srz.
| PDB = {{PDB2|1srz}}, {{PDB2|1ss2}}
| Name = Gamma-aminobutyric acid (GABA) B receptor, 1
| HGNCid = 4070
| Symbol = GABBR1
| AltSymbols =; GABAB(1e); GABABR1; GABBR1-3; GPRC3A; dJ271M21.1.1; dJ271M21.1.2; hGB1a
| OMIM = 603540
| ECnumber = 
| Homologene = 1132
| MGIid = 1860139
| GeneAtlas_image1 = PBB_GE_GABBR1_205890_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GABBR1_203146_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004965 |text = GABA-B receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007214 |text = gamma-aminobutyric acid signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2550
    | Hs_Ensembl = ENSG00000204681
    | Hs_RefseqProtein = NP_001461
    | Hs_RefseqmRNA = NM_001470
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 29631368
    | Hs_GenLoc_end = 29778041
    | Hs_Uniprot = Q9UBS5
    | Mm_EntrezGene = 54393
    | Mm_Ensembl = ENSMUSG00000024462
    | Mm_RefseqmRNA = XM_001001239
    | Mm_RefseqProtein = XP_001001239
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 36654748
    | Mm_GenLoc_end = 36681079
    | Mm_Uniprot = Q6PGJ2
  }}
}}
'''Gamma-aminobutyric acid (GABA) B receptor, 1''', also known as '''GABBR1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GABBR1 has been shown to [[Protein-protein interaction|interact]] with [[ATF4]]<ref name=pmid11087824>{{cite journal |vauthors=White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH | title = The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 97 | issue = 25 | pages = 13967–72 | date = December 2000 | pmid = 11087824 | pmc = 17684 | doi = 10.1073/pnas.240452197 }}</ref> and [[GABBR2]].<ref name=pmid9872316>{{cite journal |vauthors=White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH | title = Heterodimerization is required for the formation of a functional GABA(B) receptor | journal = [[Nature (journal)|Nature]] | volume = 396 | issue = 6712 | pages = 679–82 | date = December 1998 | pmid = 9872316 | doi = 10.1038/25354 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text = Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system.  GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region.  Alternative splicing of this gene generates 4 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2550| accessdate = }}</ref>
}}


==See also==
==See also==
Line 61: Line 14:


==References==
==References==
{{reflist|2}}
{{reflist}}
{{Clear}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal |vauthors=Fraser DD, Mudrick-Donnon LA, MacVicar BA | title = Astrocytic GABA receptors. | journal = Glia | volume = 11 | issue = 2 | pages = 83–93 | year = 1994 | pmid = 7927650 | doi = 10.1002/glia.440110203 }}
| citations =
*{{cite journal |vauthors=Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Fraser DD, Mudrick-Donnon LA, MacVicar BA |title=Astrocytic GABA receptors. |journal=Glia |volume=11 |issue= 2 |pages= 83-93 |year= 1994 |pmid= 7927650 |doi= 10.1002/glia.440110203 }}
*{{cite journal |vauthors=Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B | title = Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors | journal = Nature | volume = 386 | issue = 6622 | pages = 239–46 | year = 1997 | pmid = 9069281 | doi = 10.1038/386239a0 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Kaupmann K, Huggel K, Heid J, ''et al.'' |title=Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. |journal=Nature |volume=386 |issue= 6622 |pages= 239-46 |year= 1997 |pmid= 9069281 |doi= 10.1038/386239a0 }}
*{{cite journal |vauthors=Grifa A, Totaro A, Rommens JM, Carella M, Roetto A, Borgato L, Zelante L, Gasparini P | title = GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene | journal = Biochem. Biophys. Res. Commun. | volume = 250 | issue = 2 | pages = 240–5 | year = 1998 | pmid = 9753614 | doi = 10.1006/bbrc.1998.9296 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal |vauthors=Goei VL, Choi J, Ahn J, Bowlus CL, Raha-Chowdhury R, Gruen JR | title = Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization | journal = Biol. Psychiatry | volume = 44 | issue = 8 | pages = 659–66 | year = 1999 | pmid = 9798068 | doi = 10.1016/S0006-3223(98)00244-3 }}
*{{cite journal | author=Grifa A, Totaro A, Rommens JM, ''et al.'' |title=GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=250 |issue= 2 |pages= 240-5 |year= 1998 |pmid= 9753614 |doi= 10.1006/bbrc.1998.9296 }}
*{{cite journal |vauthors=Kaupmann K, Schuler V, Mosbacher J, Bischoff S, Bittiger H, Heid J, Froestl W, Leonhard S, Pfaff T, Karschin A, Bettler B | title = Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 25 | pages = 14991–6 | year = 1999 | pmid = 9844003 | pmc = 24563 | doi = 10.1073/pnas.95.25.14991 }}
*{{cite journal | author=Goei VL, Choi J, Ahn J, ''et al.'' |title=Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. |journal=Biol. Psychiatry |volume=44 |issue= 8 |pages= 659-66 |year= 1999 |pmid= 9798068 |doi= }}
*{{cite journal |vauthors=White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH | title = Heterodimerization is required for the formation of a functional GABA(B) receptor | journal = Nature | volume = 396 | issue = 6712 | pages = 679–82 | year = 1999 | pmid = 9872316 | doi = 10.1038/25354 }}
*{{cite journal | author=Kaupmann K, Schuler V, Mosbacher J, ''et al.'' |title=Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 25 |pages= 14991-6 |year= 1999 |pmid= 9844003 |doi= }}
*{{cite journal |vauthors=Kuner R, Köhr G, Grünewald S, Eisenhardt G, Bach A, Kornau HC | title = Role of heteromer formation in GABAB receptor function | journal = Science | volume = 283 | issue = 5398 | pages = 74–7 | year = 1999 | pmid = 9872744 | doi = 10.1126/science.283.5398.74 }}
*{{cite journal | author=White JH, Wise A, Main MJ, ''et al.'' |title=Heterodimerization is required for the formation of a functional GABA(B) receptor. |journal=Nature |volume=396 |issue= 6712 |pages= 679-82 |year= 1999 |pmid= 9872316 |doi= 10.1038/25354 }}
*{{cite journal | author = Makoff A | title = Molecular cloning of human GABABR1 and its tissue distribution | journal = Brain Res. Mol. Brain Res. | volume = 64 | issue = 1 | pages = 137–40 | year = 1999 | pmid = 9889352 | doi = 10.1016/S0169-328X(98)00316-7 }}
*{{cite journal | author=Kuner R, Köhr G, Grünewald S, ''et al.'' |title=Role of heteromer formation in GABAB receptor function. |journal=Science |volume=283 |issue= 5398 |pages= 74-7 |year= 1999 |pmid= 9872744 |doi= }}
*{{cite journal |vauthors=Peters HC, Kämmer G, Volz A, Kaupmann K, Ziegler A, Bettler B, Epplen JT, Sander T, Riess O | title = Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy | journal = Neurogenetics | volume = 2 | issue = 1 | pages = 47–54 | year = 2000 | pmid = 9933300 | doi = 10.1007/s100480050051 }}
*{{cite journal | author=Makoff A |title=Molecular cloning of human GABABR1 and its tissue distribution. |journal=Brain Res. Mol. Brain Res. |volume=64 |issue= 1 |pages= 137-40 |year= 1999 |pmid= 9889352 |doi= }}
*{{cite journal |vauthors=Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF, Evans JF, Bonner TI, O'Neill GP | title = Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity | journal = J. Biol. Chem. | volume = 274 | issue = 12 | pages = 7607–10 | year = 1999 | pmid = 10075644 | doi = 10.1074/jbc.274.12.7607 }}
*{{cite journal | author=Peters HC, Kämmer G, Volz A, ''et al.'' |title=Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy. |journal=Neurogenetics |volume=2 |issue= 1 |pages= 47-54 |year= 2000 |pmid= 9933300 |doi= }}
*{{cite journal |vauthors=Sander T, Peters C, Kämmer G, Samochowiec J, Zirra M, Mischke D, Ziegler A, Kaupmann K, Bettler B, Epplen JT, Riess O | title = Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy | journal = Am. J. Med. Genet. | volume = 88 | issue = 4 | pages = 305–10 | year = 1999 | pmid = 10402495 | doi = 10.1002/(SICI)1096-8628(19990820)88:4<305::AID-AJMG5>3.0.CO;2-X }}
*{{cite journal | author=Ng GY, Clark J, Coulombe N, ''et al.'' |title=Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7607-10 |year= 1999 |pmid= 10075644 |doi= }}
*{{cite journal |vauthors=Wise A, Green A, Main MJ, Wilson R, Fraser N, Marshall FH | title = Calcium sensing properties of the GABA(B) receptor | journal = Neuropharmacology | volume = 38 | issue = 11 | pages = 1647–56 | year = 1999 | pmid = 10587080 | doi = 10.1016/S0028-3908(99)00119-7 }}
*{{cite journal | author=Sander T, Peters C, Kämmer G, ''et al.'' |title=Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy. |journal=Am. J. Med. Genet. |volume=88 |issue= 4 |pages= 305-10 |year= 1999 |pmid= 10402495 |doi= }}
*{{cite journal |vauthors=Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY | title = Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor | journal = J. Pharmacol. Exp. Ther. | volume = 293 | issue = 2 | pages = 460–7 | year = 2000 | pmid = 10773016 | doi =  }}
*{{cite journal | author=Wise A, Green A, Main MJ, ''et al.'' |title=Calcium sensing properties of the GABA(B) receptor. |journal=Neuropharmacology |volume=38 |issue= 11 |pages= 1647-56 |year= 1999 |pmid= 10587080 |doi= }}
*{{cite journal |vauthors=Schwarz DA, Barry G, Eliasof SD, Petroski RE, Conlon PJ, Maki RA | title = Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor | journal = J. Biol. Chem. | volume = 275 | issue = 41 | pages = 32174–81 | year = 2000 | pmid = 10906333 | doi = 10.1074/jbc.M005333200 }}
*{{cite journal | author=Sullivan R, Chateauneuf A, Coulombe N, ''et al.'' |title=Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor. |journal=J. Pharmacol. Exp. Ther. |volume=293 |issue= 2 |pages= 460-7 |year= 2000 |pmid= 10773016 |doi=  }}
*{{cite journal |vauthors=White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH | title = The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 25 | pages = 13967–72 | year = 2001 | pmid = 11087824 | pmc = 17684 | doi = 10.1073/pnas.240452197 }}
*{{cite journal | author=Schwarz DA, Barry G, Eliasof SD, ''et al.'' |title=Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32174-81 |year= 2000 |pmid= 10906333 |doi= 10.1074/jbc.M005333200 }}
*{{cite journal |vauthors=Couve A, Kittler JT, Uren JM, Calver AR, Pangalos MN, Walsh FS, Moss SJ | title = Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins | journal = Mol. Cell. Neurosci. | volume = 17 | issue = 2 | pages = 317–28 | year = 2001 | pmid = 11178869 | doi = 10.1006/mcne.2000.0938 }}
*{{cite journal | author=White JH, McIllhinney RA, Wise A, ''et al.'' |title=The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13967-72 |year= 2001 |pmid= 11087824 |doi= 10.1073/pnas.240452197 }}
*{{cite journal |vauthors=Muñoz A, Arellano JI, DeFelipe J | title = GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy | journal = J. Comp. Neurol. | volume = 449 | issue = 2 | pages = 166–79 | year = 2002 | pmid = 12115687 | doi = 10.1002/cne.10287 }}
*{{cite journal  | author=Couve A, Kittler JT, Uren JM, ''et al.'' |title=Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins. |journal=Mol. Cell. Neurosci. |volume=17 |issue= 2 |pages= 317-28 |year= 2001 |pmid= 11178869 |doi= 10.1006/mcne.2000.0938 }}
*{{cite journal | author=Muñoz A, Arellano JI, DeFelipe J |title=GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy. |journal=J. Comp. Neurol. |volume=449 |issue= 2 |pages= 166-79 |year= 2002 |pmid= 12115687 |doi= 10.1002/cne.10287 }}
}}
{{refend}}
{{refend}}


==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2197 | title = GABA<sub>B</sub> Receptors: GABA<sub>B1</sub> | accessdate = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
{{PDB Gallery|geneid=2550}}
{{G protein-coupled receptors|g3}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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n/a

UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gamma-aminobutyric acid (GABA) B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.

Function

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.[1]

Interactions

GABBR1 has been shown to interact with ATF4[2] and GABBR2.[3]

See also

References

  1. ↑ "Entrez Gene: GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1".
  2. ↑ White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (December 2000). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–72. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
  3. ↑ White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (December 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316.

Further reading

  • Fraser DD, Mudrick-Donnon LA, MacVicar BA (1994). "Astrocytic GABA receptors". Glia. 11 (2): 83–93. doi:10.1002/glia.440110203. PMID 7927650.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B (1997). "Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors". Nature. 386 (6622): 239–46. doi:10.1038/386239a0. PMID 9069281.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Grifa A, Totaro A, Rommens JM, Carella M, Roetto A, Borgato L, Zelante L, Gasparini P (1998). "GABA (gamma-amino-butyric acid) neurotransmission: identification and fine mapping of the human GABAB receptor gene". Biochem. Biophys. Res. Commun. 250 (2): 240–5. doi:10.1006/bbrc.1998.9296. PMID 9753614.
  • Goei VL, Choi J, Ahn J, Bowlus CL, Raha-Chowdhury R, Gruen JR (1999). "Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization". Biol. Psychiatry. 44 (8): 659–66. doi:10.1016/S0006-3223(98)00244-3. PMID 9798068.
  • Kaupmann K, Schuler V, Mosbacher J, Bischoff S, Bittiger H, Heid J, Froestl W, Leonhard S, Pfaff T, Karschin A, Bettler B (1999). "Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels". Proc. Natl. Acad. Sci. U.S.A. 95 (25): 14991–6. doi:10.1073/pnas.95.25.14991. PMC 24563. PMID 9844003.
  • White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679–82. doi:10.1038/25354. PMID 9872316.
  • Kuner R, Köhr G, Grünewald S, Eisenhardt G, Bach A, Kornau HC (1999). "Role of heteromer formation in GABAB receptor function". Science. 283 (5398): 74–7. doi:10.1126/science.283.5398.74. PMID 9872744.
  • Makoff A (1999). "Molecular cloning of human GABABR1 and its tissue distribution". Brain Res. Mol. Brain Res. 64 (1): 137–40. doi:10.1016/S0169-328X(98)00316-7. PMID 9889352.
  • Peters HC, Kämmer G, Volz A, Kaupmann K, Ziegler A, Bettler B, Epplen JT, Sander T, Riess O (2000). "Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy". Neurogenetics. 2 (1): 47–54. doi:10.1007/s100480050051. PMID 9933300.
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External links

  • "GABAB Receptors: GABAB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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