TAAR8: Difference between revisions

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Latest revision as of 05:13, 7 November 2018

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene.^[1]^[2]^[3] In humans, TAAR8 is the only trace amine-associated receptor that is known to be G_i/o-coupled.^[4]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]^[3]

References

↑ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
↑ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
↑ ^3.0 ^3.1 "Entrez Gene: TAAR8 trace amine associated receptor 8".
↑ Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H (2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". Int J Mol Sci. 15 (11): 20638–55. doi:10.3390/ijms151120638. PMC 4264187. PMID 25391046.

Borowsky B, Adham N, Jones KA, et al. (2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid11574155-1] Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.

[pmid15718104-2] Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (Feb 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.

[entrez-3] 3.0 ^3.1 "Entrez Gene: TAAR8 trace amine associated receptor 8".

[Gi/o-4] Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H (2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". Int J Mol Sci. 15 (11): 20638–55. doi:10.3390/ijms151120638. PMC 4264187. PMID 25391046.

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[4]

@@ Line 1: / Line 1: @@
+{{Infobox_gene}}
+'''Trace amine-associated receptor 8''' is a [[protein]] that in humans is encoded by the ''TAAR8'' [[gene]].<ref name="pmid11574155">{{cite journal | vauthors = Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF | title = Discovery and mapping of ten novel G protein-coupled receptor genes | journal = Gene | volume = 275 | issue = 1 | pages = 83–91 |date=Sep 2001 | pmid = 11574155 | pmc =  | doi =10.1016/S0378-1119(01)00651-5  }}</ref><ref name="pmid15718104">{{cite journal | vauthors = Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC | title = Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors | journal = Genomics | volume = 85 | issue = 3 | pages = 372–85 |date=Feb 2005 | pmid = 15718104 | pmc =  | doi = 10.1016/j.ygeno.2004.11.010 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref> In humans, TAAR8 is the only [[trace amine-associated receptor]] that is known to be [[Gi subunit|G<sub>i/o</sub>-coupled]].<ref name="Gi/o">{{cite journal | vauthors = Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H | title = Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile | journal = Int J Mol Sci | volume = 15 | issue = 11 | pages = 20638–55 | year = 2014 | pmid = 25391046 | pmc = 4264187 | doi = 10.3390/ijms151120638 | url = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Trace amine associated receptor 8
- | HGNCid = 14964
- | Symbol = TAAR8
- | AltSymbols =; GPR102; TA5; TAR5; TRAR5
- | OMIM = 606927
- | ECnumber =
- | Homologene = 14242
- | MGIid = 2685076
-  | GeneAtlas_image1 = PBB_GE_TAAR8_gnf1h01258_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
-  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 83551
-    | Hs_Ensembl = ENSG00000146385
-    | Hs_RefseqProtein = NP_444508
-    | Hs_RefseqmRNA = NM_053278
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 132915525
-    | Hs_GenLoc_end = 132916553
-    | Hs_Uniprot = Q969N4
-    | Mm_EntrezGene = 215859
-    | Mm_Ensembl = ENSMUSG00000050804
-    | Mm_RefseqmRNA = NM_001010830
-    | Mm_RefseqProtein = NP_001010830
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 10
-    | Mm_GenLoc_start = 23765916
-    | Mm_GenLoc_end = 23766950
-    | Mm_Uniprot = Q5QD07
-  }}
-}}
-'''Trace amine associated receptor 8''', also known as '''TAAR8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TAAR8 trace amine associated receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83551| accessdate = }}</ref>
+| summary_text = G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]<ref name="entrez" />
 }}
@@ Line 66: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Borowsky B, Adham N, Jones KA, ''et al.'' |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966-71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198 }}
+*{{cite journal   |vauthors=Borowsky B, Adham N, Jones KA, etal |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966–71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198  | pmc=55357 }}
-*{{cite journal  | author=Lee DK, Nguyen T, Lynch KR, ''et al.'' |title=Discovery and mapping of ten novel G protein-coupled receptor genes. |journal=Gene |volume=275 |issue= 1 |pages= 83-91 |year= 2001 |pmid= 11574155 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
-*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Lindemann L, Ebeling M, Kratochwil NA, ''et al.'' |title=Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |journal=Genomics |volume=85 |issue= 3 |pages= 372-85 |year= 2005 |pmid= 15718104 |doi= 10.1016/j.ygeno.2004.11.010 }}
 }}
 {{refend}}
 {{NLM content}}
+{{TAAR ligands}}
 {{G protein-coupled receptors}}
-[[Category:G protein coupled receptors]]
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+{{PBB_Controls
+| update_page = yes
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+[[Category:G protein-coupled receptors]]
+{{transmembranereceptor-stub}}

TAAR8: Difference between revisions

Latest revision as of 05:13, 7 November 2018

See also

References

Further reading

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