GPR34: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Probable G-protein coupled receptor 34''' is a [[protein]] that in humans is encoded by the ''GPR34'' [[gene]].<ref name="pmid10395919">{{cite journal | vauthors = Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T | title = A novel subgroup of class I G-protein-coupled receptors | journal = Biochimica et Biophysica Acta | volume = 1446 | issue = 1-2 | pages = 57–70 | date = July 1999 | pmid = 10395919 | pmc =  | doi = 10.1016/s0167-4781(99)00081-0 }}</ref><ref name="pmid10036181">{{cite journal | vauthors = Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF | title = Discovery of three novel orphan G-protein-coupled receptors | journal = Genomics | volume = 56 | issue = 1 | pages = 12–21 | date = February 1999 | pmid = 10036181 | pmc = | doi = 10.1006/geno.1998.5655 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR34 G protein-coupled receptor 34| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2857| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = G protein-coupled receptor 34
| HGNCid = 4490
| Symbol = GPR34
| AltSymbols =;
| OMIM = 300241
| ECnumber = 
| Homologene = 36174
| MGIid = 1346334
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2857
    | Hs_Ensembl = ENSG00000171659
    | Hs_RefseqProtein = NP_001028685
    | Hs_RefseqmRNA = NM_001033513
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 41433170
    | Hs_GenLoc_end = 41441470
    | Hs_Uniprot = Q9UPC5
    | Mm_EntrezGene = 23890
    | Mm_Ensembl = ENSMUSG00000040229
    | Mm_RefseqmRNA = NM_011823
    | Mm_RefseqProtein = NP_035953
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 12789097
    | Mm_GenLoc_end = 12797817
    | Mm_Uniprot = Q3USC5
  }}
}}
'''G protein-coupled receptor 34''', also known as '''GPR34''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR34 G protein-coupled receptor 34| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2857| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GPR34 G protein-coupled receptor 34| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2857| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = September 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
| citations =
* {{cite journal | vauthors = Jacobi FK, Broghammer M, Pesch K, Zrenner E, Berger W, Meindl A, Pusch CM | title = Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1 | journal = Human Genetics | volume = 107 | issue = 1 | pages = 89–91 | date = July 2000 | pmid = 10982042 | doi = 10.1007/s004390050017 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal  | author=Marchese A, Sawzdargo M, Nguyen T, ''et al.'' |title=Discovery of three novel orphan G-protein-coupled receptors. |journal=Genomics |volume=56 |issue= 1 |pages= 12-21 |year= 1999 |pmid= 10036181 |doi= 10.1006/geno.1998.5655 }}
* {{cite journal | vauthors = Engemaier E, Römpler H, Schöneberg T, Schulz A | title = Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34 | journal = Genomics | volume = 87 | issue = 2 | pages = 254–64 | date = February 2006 | pmid = 16338117 | doi = 10.1016/j.ygeno.2005.10.001 }}
*{{cite journal  | author=Schöneberg T, Schulz A, Grosse R, ''et al.'' |title=A novel subgroup of class I G-protein-coupled receptors. |journal=Biochim. Biophys. Acta |volume=1446 |issue= 1-2 |pages= 57-70 |year= 1999 |pmid= 10395919 |doi=  }}
* {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = December 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Jacobi FK, Broghammer M, Pesch K, ''et al.'' |title=Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1. |journal=Hum. Genet. |volume=107 |issue= 1 |pages= 89-91 |year= 2000 |pmid= 10982042 |doi=  }}
* {{cite journal | vauthors = Liebscher I, Müller U, Teupser D, Engemaier E, Engel KM, Ritscher L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S, Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schöneberg T, Schulz A | title = Altered immune response in mice deficient for the G protein-coupled receptor GPR34 | journal = The Journal of Biological Chemistry | volume = 286 | issue = 3 | pages = 2101–10 | date = January 2011 | pmid = 21097509 | pmc = 3023507 | doi = 10.1074/jbc.M110.196659 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T | title = The ligand specificity of the G-protein-coupled receptor GPR34 | journal = The Biochemical Journal | volume = 443 | issue = 3 | pages = 841–50 | date = May 2012 | pmid = 22348703 | doi = 10.1042/BJ20112090 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Engemaier E, Römpler H, Schöneberg T, Schulz A |title=Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34. |journal=Genomics |volume=87 |issue= 2 |pages= 254-64 |year= 2006 |pmid= 16338117 |doi= 10.1016/j.ygeno.2005.10.001 }}
*{{cite journal | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[1][2][3]

Function

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][3]

References

  1. ↑ Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (July 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta. 1446 (1–2): 57–70. doi:10.1016/s0167-4781(99)00081-0. PMID 10395919.
  2. ↑ Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID 10036181.
  3. ↑ 3.0 3.1 "Entrez Gene: GPR34 G protein-coupled receptor 34".

Further reading

  • Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Jacobi FK, Broghammer M, Pesch K, Zrenner E, Berger W, Meindl A, Pusch CM (July 2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics. 107 (1): 89–91. doi:10.1007/s004390050017. PMID 10982042.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Engemaier E, Römpler H, Schöneberg T, Schulz A (February 2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics. 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117.
  • Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
  • Liebscher I, Müller U, Teupser D, Engemaier E, Engel KM, Ritscher L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S, Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schöneberg T, Schulz A (January 2011). "Altered immune response in mice deficient for the G protein-coupled receptor GPR34". The Journal of Biological Chemistry. 286 (3): 2101–10. doi:10.1074/jbc.M110.196659. PMC 3023507. PMID 21097509.
  • Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T (May 2012). "The ligand specificity of the G-protein-coupled receptor GPR34". The Biochemical Journal. 443 (3): 841–50. doi:10.1042/BJ20112090. PMID 22348703.
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