Free fatty acid receptor: Difference between revisions
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imported>Ser Amantio di Nicolao m Moving from Category:G protein coupled receptors to Category:G protein-coupled receptors using Cat-a-lot |
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The '''free fatty acid receptor''' is a [[G-protein coupled receptor]] which binds [[free fatty acids]].<ref name="pmid17052194">{{cite journal | vauthors = Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK | title = The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing | journal = Biochem. Soc. Trans. | volume = 34 | issue = Pt 5 | pages = 770–3 | year = 2006 | pmid = 17052194 | doi = 10.1042/BST0340770 }}</ref> There are four variants of the receptor, each encoded by a separate gene ([[FFAR1 (gene)|FFAR1]], [[FFAR2]], [[FFAR3]], [[FFAR4 (gene)|FFAR4]]). Preliminary findings suggest that [[FFAR2]] and [[FFAR3]] may interact to form a [[FFAR2-FFAR3 receptor heteromer]]. <ref>{{Cite journal| doi = 10.1096/fj.201700252RR| issn = 0892-6638| pages = –201700252RR| last1 = Ang| first1 = Zhiwei| last2 = Xiong| first2 = Ding| last3 = Wu| first3 = Min| last4 = Ding| first4 = Jeak Ling| title = FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing| journal = The FASEB Journal| accessdate = 2017-09-10| date = 2017-09-07| url = http://www.fasebj.org/content/early/2017/09/07/fj.201700252RR| pmid = 28883043}}</ref> | The '''free fatty acid receptor''' is a [[G-protein coupled receptor]] which binds [[free fatty acids]].<ref name="pmid17052194">{{cite journal | vauthors = Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK | title = The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing | journal = Biochem. Soc. Trans. | volume = 34 | issue = Pt 5 | pages = 770–3 | year = 2006 | pmid = 17052194 | doi = 10.1042/BST0340770 }}</ref> There are four variants of the receptor, each encoded by a separate gene ([[FFAR1 (gene)|FFAR1]], [[FFAR2]], [[FFAR3]], [[FFAR4 (gene)|FFAR4]]). Preliminary findings suggest that [[FFAR2]] and [[FFAR3]] may interact to form a [[FFAR2-FFAR3 receptor heteromer]]. <ref>{{Cite journal| doi = 10.1096/fj.201700252RR| issn = 0892-6638| pages = –201700252RR| last1 = Ang| first1 = Zhiwei| last2 = Xiong| first2 = Ding| last3 = Wu| first3 = Min| last4 = Ding| first4 = Jeak Ling| title = FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing| journal = The FASEB Journal| accessdate = 2017-09-10| date = 2017-09-07| url = http://www.fasebj.org/content/early/2017/09/07/fj.201700252RR| pmid = 28883043| volume=32| pmc=5731126}}</ref> | ||
==References== | ==References== | ||
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{{G protein-coupled receptors}} | {{G protein-coupled receptors}} | ||
[[Category:G protein coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
{{transmembranereceptor-stub}} | {{transmembranereceptor-stub}} | ||
Latest revision as of 18:00, 24 September 2018
| free fatty acid receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | FFAR1, FFA1R |
| Alt. symbols | GPR40 |
| Entrez | 2864 |
| HUGO | 4498 |
| OMIM | 603820 |
| RefSeq | NM_005303 |
| UniProt | O14842 |
| Other data | |
| Locus | Chr. 19 q13.1 |
| free fatty acid receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | FFAR2 |
| Alt. symbols | GPR43, FFA2R |
| Entrez | 2867 |
| HUGO | 4501 |
| OMIM | 603823 |
| RefSeq | NM_005306 |
| UniProt | O15552 |
| Other data | |
| Locus | Chr. 19 q13.1 |
| free fatty acid receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | FFAR3 |
| Alt. symbols | GPR41, FFA3R |
| Entrez | 2865 |
| HUGO | 4499 |
| OMIM | 603821 |
| RefSeq | NM_005304 |
| UniProt | O14843 |
| Other data | |
| Locus | Chr. 19 q13.1 |
| G protein-coupled receptor 42 | |
|---|---|
| Identifiers | |
| Symbol | GPR42 |
| Alt. symbols | GPR41L, FFAR1L |
| Entrez | 2866 |
| HUGO | 4500 |
| OMIM | 603822 |
| RefSeq | NM_005305 |
| UniProt | O15529 |
| Other data | |
| Locus | Chr. 19 q31.1 |
The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids.[1] There are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FFAR3 may interact to form a FFAR2-FFAR3 receptor heteromer. [2]
References
- ↑ Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). "The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing". Biochem. Soc. Trans. 34 (Pt 5): 770–3. doi:10.1042/BST0340770. PMID 17052194.
- ↑ Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32: –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.
External links
- "Free Fatty Acid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- FFAR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- G-protein+coupled+receptor+43,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FFAR3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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