VN1R1: Difference between revisions

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'''Vomeronasal type-1 receptor 1''' is a [[protein]] that in humans is encoded by the ''VN1R1'' [[gene]].<ref name="pmid10973240">{{cite journal | vauthors = Rodriguez I, Greer CA, Mok MY, Mombaerts P | title = A putative pheromone receptor gene expressed in human olfactory mucosa | journal = Nat Genet | volume = 26 | issue = 1 | pages = 18–9 |date=Oct 2000 | pmid = 10973240 | pmc =  | doi = 10.1038/79124 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VN1R1 vomeronasal 1 receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57191| accessdate = }}</ref>
'''Vomeronasal type-1 receptor 1''' is a [[protein]] that in humans is encoded by the ''VN1R1'' [[gene]].<ref name="pmid10973240">{{cite journal | vauthors = Rodriguez I, Greer CA, Mok MY, Mombaerts P | title = A putative pheromone receptor gene expressed in human olfactory mucosa | journal = Nature Genetics | volume = 26 | issue = 1 | pages = 18–9 | date = September 2000 | pmid = 10973240 | pmc =  | doi = 10.1038/79124 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VN1R1 vomeronasal 1 receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57191| access-date = }}</ref>


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== Function ==
{{PBB_Summary
| section_title =  
| summary_text = Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.<ref name="entrez" />
}}


==References==
[[Pheromone]]s are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An [[alternative splicing|alternate splice]] variant of this gene is thought to exist, but its full length nature has not been determined.<ref name="entrez" />
 
==Ligands==
 
* [[Hedione]]<ref name="Wallrabenstein_2015">{{cite journal | vauthors = Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H | title = The smelling of Hedione results in sex-differentiated human brain activity | journal = NeuroImage | volume = 113 | issue =  | pages = 365–73 | date = June 2015 | pmid = 25797832 | doi = 10.1016/j.neuroimage.2015.03.029 }}</ref>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Giorgi D, Friedman C, Trask BJ, Rouquier S | title = Characterization of nonfunctional V1R-like pheromone receptor sequences in human | journal = Genome Research | volume = 10 | issue = 12 | pages = 1979–85 | date = December 2000 | pmid = 11116092 | pmc = 313059 | doi = 10.1101/gr.10.12.1979 }}
| citations =
* {{cite journal | vauthors = Pantages E, Dulac C | title = A novel family of candidate pheromone receptors in mammals | journal = Neuron | volume = 28 | issue = 3 | pages = 835–45 | date = December 2000 | pmid = 11163270 | doi = 10.1016/S0896-6273(00)00157-4 }}
*{{cite journal | vauthors=Giorgi D, Friedman C, Trask BJ, Rouquier S |title=Characterization of nonfunctional V1R-like pheromone receptor sequences in human |journal=Genome Res. |volume=10 |issue= 12 |pages= 1979–85 |year= 2001 |pmid= 11116092 |doi=10.1101/gr.10.12.1979 | pmc=313059  }}
* {{cite journal | vauthors = Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S | title = Identification of G protein-coupled receptor genes from the human genome sequence | journal = FEBS Letters | volume = 520 | issue = 1-3 | pages = 97–101 | date = June 2002 | pmid = 12044878 | doi = 10.1016/S0014-5793(02)02775-8 }}
*{{cite journal | vauthors=Pantages E, Dulac C |title=A novel family of candidate pheromone receptors in mammals |journal=Neuron |volume=28 |issue= 3 |pages= 835–45 |year= 2001 |pmid= 11163270 |doi=10.1016/S0896-6273(00)00157-4 }}
* {{cite journal | vauthors = Zhang J, Webb DM | title = Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 14 | pages = 8337–41 | date = July 2003 | pmid = 12826614 | pmc = 166230 | doi = 10.1073/pnas.1331721100 }}
*{{cite journal   |vauthors=Takeda S, Kadowaki S, Haga T, etal |title=Identification of G protein-coupled receptor genes from the human genome sequence |journal=FEBS Lett. |volume=520 |issue= 1–3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=10.1016/S0014-5793(02)02775-8 }}
* {{cite journal | vauthors = Mitropoulos C, Papachatzopoulou A, Menounos PG, Kolonelou C, Pappa M, Bertolis G, Gerou S, Patrinos GP | title = Association study of human VN1R1 pheromone receptor gene alleles and gender | journal = Genetic Testing | volume = 11 | issue = 2 | pages = 128–32 | year = 2007 | pmid = 17627382 | doi = 10.1089/gte.2006.0516 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | vauthors=Zhang J, Webb DM |title=Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8337–41 |year= 2003 |pmid= 12826614 |doi= 10.1073/pnas.1331721100  | pmc=166230 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Mitropoulos C, Papachatzopoulou A, Menounos PG, etal |title=Association study of human VN1R1 pheromone receptor gene alleles and gender |journal=Genet. Test. |volume=11 |issue= 2 |pages= 128–32 |year= 2007 |pmid= 17627382 |doi= 10.1089/gte.2006.0516 }}
}}
{{refend}}
{{refend}}


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{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
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[[Category:G protein coupled receptors]]


[[Category:G protein-coupled receptors]]
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Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Vomeronasal type-1 receptor 1 is a protein that in humans is encoded by the VN1R1 gene.[1][2]

Function

Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.[2]

Ligands

References

  1. ↑ Rodriguez I, Greer CA, Mok MY, Mombaerts P (September 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nature Genetics. 26 (1): 18–9. doi:10.1038/79124. PMID 10973240.
  2. ↑ 2.0 2.1 "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".
  3. ↑ Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H (June 2015). "The smelling of Hedione results in sex-differentiated human brain activity". NeuroImage. 113: 365–73. doi:10.1016/j.neuroimage.2015.03.029. PMID 25797832.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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