P2RY14: Difference between revisions

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imported>Ser Amantio di Nicolao
 
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{{Infobox_gene}}
 
'''P2Y purinoceptor 14''' is a [[protein]] that in humans is encoded by the ''P2RY14'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9934| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Purinergic receptor P2Y, G-protein coupled, 14
| HGNCid = 16442
| Symbol = P2RY14
| AltSymbols =; GPR105; KIAA0001; P2Y14
| OMIM = 610116
| ECnumber = 
| Homologene = 15769
| MGIid = 2155705
| GeneAtlas_image1 = PBB_GE_P2RY14_206637_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}} {{GNF_GO|id=GO:0045029 |text = UDP-activated nucleotide receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9934
    | Hs_Ensembl = ENSG00000174944
    | Hs_RefseqProtein = NP_001074924
    | Hs_RefseqmRNA = NM_001081455
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 152412595
    | Hs_GenLoc_end = 152478847
    | Hs_Uniprot = Q15391
    | Mm_EntrezGene = 140795
    | Mm_Ensembl = ENSMUSG00000036381
    | Mm_RefseqmRNA = NM_001008497
    | Mm_RefseqProtein = NP_001008497
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 59202554
    | Mm_GenLoc_end = 59219257
    | Mm_Uniprot = Q544F4
  }}
}}
'''Purinergic receptor P2Y, G-protein coupled, 14''', also known as '''P2RY14''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9934| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9934| accessdate = }}</ref>
| summary_text = The product of this gene, P2Y<sub>14</sub> belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.<ref name="entrez" />
}}
}}


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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gerard C, Gerard NP |title=C5A anaphylatoxin and its seven transmembrane-segment receptor. |journal=Annu. Rev. Immunol. |volume=12 |issue=  |pages= 775-808 |year= 1994 |pmid= 8011297 |doi= 10.1146/annurev.iy.12.040194.004015 }}
*{{cite journal  | vauthors=Gerard C, Gerard NP |title=C5A anaphylatoxin and its seven transmembrane-segment receptor |journal=Annu. Rev. Immunol. |volume=12 |issue=  |pages= 775–808 |year= 1994 |pmid= 8011297 |doi= 10.1146/annurev.iy.12.040194.004015 }}
*{{cite journal  | author=Müller CE |title=P2-pyrimidinergic receptors and their ligands. |journal=Curr. Pharm. Des. |volume=8 |issue= 26 |pages= 2353-69 |year= 2003 |pmid= 12369950 |doi=  }}
*{{cite journal  | author=Müller CE |title=P2-pyrimidinergic receptors and their ligands |journal=Curr. Pharm. Des. |volume=8 |issue= 26 |pages= 2353–69 |year= 2003 |pmid= 12369950 |doi=10.2174/1381612023392937 }}
*{{cite journal | author=Abbracchio MP, Boeynaems JM, Barnard EA, ''et al.'' |title=Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. |journal=Trends Pharmacol. Sci. |volume=24 |issue= 2 |pages= 52-5 |year= 2003 |pmid= 12559763 |doi=  }}
*{{cite journal   |vauthors=Abbracchio MP, Boeynaems JM, Barnard EA, etal |title=Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family |journal=Trends Pharmacol. Sci. |volume=24 |issue= 2 |pages= 52–5 |year= 2003 |pmid= 12559763 |doi=10.1016/S0165-6147(02)00038-X }}
*{{cite journal  | author=von Kügelgen I |title=Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. |journal=Pharmacol. Ther. |volume=110 |issue= 3 |pages= 415-32 |year= 2006 |pmid= 16257449 |doi= 10.1016/j.pharmthera.2005.08.014 }}
*{{cite journal  | author=von Kügelgen I |title=Pharmacological profiles of cloned mammalian P2Y-receptor subtypes |journal=Pharmacol. Ther. |volume=110 |issue= 3 |pages= 415–32 |year= 2006 |pmid= 16257449 |doi= 10.1016/j.pharmthera.2005.08.014 }}
*{{cite journal  | author=Brunschweiger A, Müller CE |title=P2 receptors activated by uracil nucleotides--an update. |journal=Curr. Med. Chem. |volume=13 |issue= 3 |pages= 289-312 |year= 2006 |pmid= 16475938 |doi=  }}
*{{cite journal  | vauthors=Brunschweiger A, Müller CE |title=P2 receptors activated by uracil nucleotides--an update |journal=Curr. Med. Chem. |volume=13 |issue= 3 |pages= 289–312 |year= 2006 |pmid= 16475938 |doi=10.2174/092986706775476052 }}
*{{cite journal | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi=  }}
*{{cite journal   |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 }}
*{{cite journal | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47-56 |year= 1995 |pmid= 7584028 |doi=  }}
*{{cite journal   |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement) |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 }}
*{{cite journal | author=Charlton ME, Williams AS, Fogliano M, ''et al.'' |title=The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge. |journal=Brain Res. |volume=764 |issue= 1-2 |pages= 141-8 |year= 1997 |pmid= 9295203 |doi=  }}
*{{cite journal   |vauthors=Charlton ME, Williams AS, Fogliano M, etal |title=The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge |journal=Brain Res. |volume=764 |issue= 1–2 |pages= 141–8 |year= 1997 |pmid= 9295203 |doi=10.1016/S0006-8993(97)00438-1 }}
*{{cite journal | author=Joensuu T, Hämäläinen R, Lehesjoki AE, ''et al.'' |title=A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q. |journal=Genomics |volume=63 |issue= 3 |pages= 409-16 |year= 2000 |pmid= 10704288 |doi= 10.1006/geno.1999.6096 }}
*{{cite journal   |vauthors=Joensuu T, Hämäläinen R, Lehesjoki AE, etal |title=A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q |journal=Genomics |volume=63 |issue= 3 |pages= 409–16 |year= 2000 |pmid= 10704288 |doi= 10.1006/geno.1999.6096 }}
*{{cite journal | author=Chambers JK, Macdonald LE, Sarau HM, ''et al.'' |title=A G protein-coupled receptor for UDP-glucose. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 10767-71 |year= 2000 |pmid= 10753868 |doi=  }}
*{{cite journal   |vauthors=Chambers JK, Macdonald LE, Sarau HM, etal |title=A G protein-coupled receptor for UDP-glucose |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 10767–71 |year= 2000 |pmid= 10753868 |doi=10.1074/jbc.275.15.10767 }}
*{{cite journal  | author=Wittenberger T, Schaller HC, Hellebrand S |title=An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. |journal=J. Mol. Biol. |volume=307 |issue= 3 |pages= 799-813 |year= 2001 |pmid= 11273702 |doi= 10.1006/jmbi.2001.4520 }}
*{{cite journal  | vauthors=Wittenberger T, Schaller HC, Hellebrand S |title=An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors |journal=J. Mol. Biol. |volume=307 |issue= 3 |pages= 799–813 |year= 2001 |pmid= 11273702 |doi= 10.1006/jmbi.2001.4520 }}
*{{cite journal | author=Joensuu T, Hämäläinen R, Yuan B, ''et al.'' |title=Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. |journal=Am. J. Hum. Genet. |volume=69 |issue= 4 |pages= 673-84 |year= 2001 |pmid= 11524702 |doi=  }}
*{{cite journal   |vauthors=Joensuu T, Hämäläinen R, Yuan B, etal |title=Mutations in a Novel Gene with Transmembrane Domains Underlie Usher Syndrome Type 3 |journal=Am. J. Hum. Genet. |volume=69 |issue= 4 |pages= 673–84 |year= 2001 |pmid= 11524702 |doi=10.1086/323610  | pmc=1226054 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Lazarowski ER, Shea DA, Boucher RC, Harden TK |title=Release of cellular UDP-glucose as a potential extracellular signaling molecule. |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1190-7 |year= 2003 |pmid= 12695547 |doi=  }}
*{{cite journal  | vauthors=Lazarowski ER, Shea DA, Boucher RC, Harden TK |title=Release of cellular UDP-glucose as a potential extracellular signaling molecule |journal=Mol. Pharmacol. |volume=63 |issue= 5 |pages= 1190–7 |year= 2003 |pmid= 12695547 |doi=10.1124/mol.63.5.1190 }}
*{{cite journal | author=Lee BC, Cheng T, Adams GB, ''et al.'' |title=P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. |journal=Genes Dev. |volume=17 |issue= 13 |pages= 1592-604 |year= 2003 |pmid= 12842911 |doi= 10.1101/gad.1071503 }}
*{{cite journal   |vauthors=Lee BC, Cheng T, Adams GB, etal |title=P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrowhematopoietic stem cells |journal=Genes Dev. |volume=17 |issue= 13 |pages= 1592–604 |year= 2003 |pmid= 12842911 |doi= 10.1101/gad.1071503 | pmc=196132 }}
*{{cite journal  | author=Skelton L, Cooper M, Murphy M, Platt A |title=Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. |journal=J. Immunol. |volume=171 |issue= 4 |pages= 1941-9 |year= 2003 |pmid= 12902497 |doi=  }}
*{{cite journal  | vauthors=Skelton L, Cooper M, Murphy M, Platt A |title=Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose |journal=J. Immunol. |volume=171 |issue= 4 |pages= 1941–9 |year= 2003 |pmid= 12902497 |doi=  10.4049/jimmunol.171.4.1941}}
*{{cite journal | author=Moore DJ, Murdock PR, Watson JM, ''et al.'' |title=GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. |journal=Brain Res. Mol. Brain Res. |volume=118 |issue= 1-2 |pages= 10-23 |year= 2004 |pmid= 14559350 |doi=  }}
*{{cite journal   |vauthors=Moore DJ, Murdock PR, Watson JM, etal |title=GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function |journal=Brain Res. Mol. Brain Res. |volume=118 |issue= 1–2 |pages= 10–23 |year= 2004 |pmid= 14559350 |doi=10.1016/S0169-328X(03)00330-9 }}
}}
}}
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{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Purinergics}}
 
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==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3050 | title = P2Y Receptors: P2Y<sub>14</sub> | accessdate = | date = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = }}
 
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{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.[1]

The product of this gene, P2Y14 belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


External links

  • "P2Y Receptors: P2Y14". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Retrieved from "https://www.wikidoc.org/index.php?title=P2RY14&oldid=1532292"