P2RY8: Difference between revisions

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{{Infobox_gene}}
'''P2Y purinoceptor 8''' is a [[protein]] that in humans is encoded by the ''P2RY8'' [[gene]].<ref name="pmid11004484">{{cite journal | vauthors = Adrian K, Bernhard MK, Breitinger HG, Ogilvie A | title = Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells | journal = Biochimica et Biophysica Acta | volume = 1492 | issue = 1 | pages = 127–38 | date = Jun 2000 | pmid = 11004484 | pmc =  | doi = 10.1016/S0167-4781(00)00094-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286530| accessdate = }}</ref>


== Function ==


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The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.<ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical relevance ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Purinergic receptor P2Y, G-protein coupled, 8
| HGNCid = 15524
| Symbol = P2RY8
| AltSymbols =; MGC50878; P2Y8
| OMIM = 300525
| ECnumber = 
| Homologene = 65345
| MGIid = 
| GeneAtlas_image1 = PBB_GE_P2RY8_gnf1h10171_at_tn.png
| GeneAtlas_image2 = PBB_GE_P2RY8_gnf1h10172_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 286530
    | Hs_Ensembl = ENSG00000182162
    | Hs_RefseqProtein = NP_835230
    | Hs_RefseqmRNA = NM_178129
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 1541465
    | Hs_GenLoc_end = 1616000
    | Hs_Uniprot = Q86VZ1
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Purinergic receptor P2Y, G-protein coupled, 8''', also known as '''P2RY8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286530| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Recurrent mutations in this gene have been associated to cases of [[diffuse large B-cell lymphoma]].<ref name=pmid.22343534>{{cite journal | vauthors = Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR | title = Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 10 | pages = 3879–84 | date = Mar 2012 | pmid = 22343534 | pmc = 3309757 | doi = 10.1073/pnas.1121343109 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286530| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[P2Y receptor]]
* [[P2Y receptor]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cantagrel V, Lossi AM, Boulanger S, Depetris D, Mattei MG, Gecz J, Schwartz CE, Van Maldergem L, Villard L | title = Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males | journal = Journal of Medical Genetics | volume = 41 | issue = 10 | pages = 736–42 | date = Oct 2004 | pmid = 15466006 | pmc = 1735597 | doi = 10.1136/jmg.2004.021626 }}
| citations =
* {{cite journal | vauthors = Fujiwara S, Yamashita Y, Choi YL, Watanabe H, Kurashina K, Soda M, Enomoto M, Hatanaka H, Takada S, Ozawa K, Mano H | title = Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening | journal = Leukemia & Lymphoma | volume = 48 | issue = 5 | pages = 978–86 | date = May 2007 | pmid = 17487742 | doi = 10.1080/10428190701225882 }}
*{{cite journal | author=Adrian K, Bernhard MK, Breitinger HG, Ogilvie A |title=Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 127-38 |year= 2000 |pmid= 11004484 |doi=  }}
* {{cite journal | vauthors = Storlazzi CT, Albano F, Lo Cunsolo C, Doglioni C, Guastadisegni MC, Impera L, Lonoce A, Funes S, Macrì E, Iuzzolino P, Panagopoulos I, Specchia G, Rocchi M | title = Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma | journal = Leukemia | volume = 21 | issue = 10 | pages = 2221–5 | date = Oct 2007 | pmid = 17554380 | doi = 10.1038/sj.leu.2404784 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Cantagrel V, Lossi AM, Boulanger S, ''et al.'' |title=Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. |journal=J. Med. Genet. |volume=41 |issue= 10 |pages= 736-42 |year= 2005 |pmid= 15466006 |doi= 10.1136/jmg.2004.021626 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Fujiwara S, Yamashita Y, Choi YL, ''et al.'' |title=Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. |journal=Leuk. Lymphoma |volume=48 |issue= 5 |pages= 978-86 |year= 2007 |pmid= 17487742 |doi= 10.1080/10428190701225882 }}
*{{cite journal | author=Storlazzi CT, Albano F, Lo Cunsolo C, ''et al.'' |title=Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma. |journal=Leukemia |volume=21 |issue= 10 |pages= 2221-5 |year= 2007 |pmid= 17554380 |doi= 10.1038/sj.leu.2404784 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Purinergics}}


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.[1][2]

Function

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.[2]

Clinical relevance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[3]

See also

References

  1. ↑ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Jun 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
  2. ↑ 2.0 2.1 "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8".
  3. ↑ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR (Mar 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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