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{{Infobox_gene}}
'''Trace amine associated receptor 6''', also known as '''TAAR6''', is a [[protein]] which in humans is encoded by the ''TAAR6'' [[gene]].<ref name="pmid11459929">{{cite journal | vauthors = Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C | title = Trace amines: identification of a family of mammalian G protein-coupled receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 16 | pages = 8966–71 |date=July 2001 | pmid = 11459929 | pmc = 55357 | doi = 10.1073/pnas.151105198 | url =  }}</ref><ref name="pmid15718104">{{cite journal | vauthors = Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC | title = Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors | journal = Genomics | volume = 85 | issue = 3 | pages = 372–85 |date=March 2005 | pmid = 15718104 | doi = 10.1016/j.ygeno.2004.11.010 | url =  }}</ref>


== Function ==


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
TAAR6 belongs to the [[trace amine-associated receptor]] family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like [[dopamine]], [[norepinephrine]], [[serotonin]], and [[histamine]]. Trace amines were thought to be 'false transmitters' that displace classic [[biogenic amine]]s from their storage and act on transporters in a fashion similar to the [[amphetamine]]s, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.<ref name="pmid15329799">{{cite journal | vauthors = Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV | title = Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia | journal = Am. J. Hum. Genet. | volume = 75 | issue = 4 | pages = 624–38 |date=October 2004 | pmid = 15329799 | pmc = 1182049 | doi = 10.1086/424887 | url =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAAR6 trace amine associated receptor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=319100| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Trace amine associated receptor 6
| HGNCid = 20978
| Symbol = TAAR6
| AltSymbols =; RP11-295F4.3; SCZD5; TA4; TRAR4
| OMIM = 608923
| ECnumber = 
| Homologene = 27874
| MGIid = 2685074
| GeneAtlas_image1 = PBB_GE_TAAR6_gnf1h10296_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 319100
    | Hs_Ensembl = ENSG00000146383
    | Hs_RefseqProtein = NP_778237
    | Hs_RefseqmRNA = NM_175067
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 132933154
    | Hs_GenLoc_end = 132934191
    | Hs_Uniprot = Q96RI8
    | Mm_EntrezGene = 215855
    | Mm_Ensembl = ENSMUSG00000045111
    | Mm_RefseqmRNA = NM_001010828
    | Mm_RefseqProtein = NP_001010828
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 23674025
    | Mm_GenLoc_end = 23675062
    | Mm_Uniprot = Q5QD13
  }}
}}
'''Trace amine associated receptor 6''', also known as '''TAAR6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAAR6 trace amine associated receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=319100| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =
| summary_text = TAAR6 belongs to the trace amine receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own (Duan et al., 2004).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TAAR6 trace amine associated receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=319100| accessdate = }}</ref>
}}
 
==See also==
* [[Trace amine-associated receptor]]


==References==
==References==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Cao Q, Martinez M, Zhang J, ''et al.'' |title=Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. |journal=Genomics |volume=43 |issue= 1 |pages= 1-8 |year= 1997 |pmid= 9226366 |doi= 10.1006/geno.1997.4815 }}
*{{cite journal   |vauthors=Cao Q, Martinez M, Zhang J, etal |title=Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. |journal=Genomics |volume=43 |issue= 1 |pages= 1–8 |year= 1997 |pmid= 9226366 |doi= 10.1006/geno.1997.4815 }}
*{{cite journal | author=Kaufmann CA, Suarez B, Malaspina D, ''et al.'' |title=NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees. |journal=Am. J. Med. Genet. |volume=81 |issue= 4 |pages= 282-9 |year= 1998 |pmid= 9674972 |doi=  }}
*{{cite journal   |vauthors=Kaufmann CA, Suarez B, Malaspina D, etal |title=NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees. |journal=Am. J. Med. Genet. |volume=81 |issue= 4 |pages= 282–9 |year= 1998 |pmid= 9674972 |doi=10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W }}
*{{cite journal | author=Borowsky B, Adham N, Jones KA, ''et al.'' |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966-71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198 }}
*{{cite journal   |vauthors=Borowsky B, Adham N, Jones KA, etal |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966–71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198 | pmc=55357 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Duan J, Martinez M, Sanders AR, ''et al.'' |title=Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. |journal=Am. J. Hum. Genet. |volume=75 |issue= 4 |pages= 624-38 |year= 2004 |pmid= 15329799 |doi= 10.1086/424887 }}
*{{cite journal   |vauthors=Duan J, Martinez M, Sanders AR, etal |title=Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. |journal=Am. J. Hum. Genet. |volume=75 |issue= 4 |pages= 624–38 |year= 2004 |pmid= 15329799 |doi= 10.1086/424887 | pmc=1182049 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Lindemann L, Ebeling M, Kratochwil NA, ''et al.'' |title=Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |journal=Genomics |volume=85 |issue= 3 |pages= 372-85 |year= 2005 |pmid= 15718104 |doi= 10.1016/j.ygeno.2004.11.010 }}
*{{cite journal   |vauthors=Lindemann L, Ebeling M, Kratochwil NA, etal |title=Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |journal=Genomics |volume=85 |issue= 3 |pages= 372–85 |year= 2005 |pmid= 15718104 |doi= 10.1016/j.ygeno.2004.11.010 }}
*{{cite journal | author=Amann D, Avidan N, Kanyas K, ''et al.'' |title=The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23. |journal=Mol. Psychiatry |volume=11 |issue= 2 |pages= 119-21 |year= 2006 |pmid= 16189505 |doi= 10.1038/sj.mp.4001752 }}
*{{cite journal   |vauthors=Amann D, Avidan N, Kanyas K, etal |title=The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23. |journal=Mol. Psychiatry |volume=11 |issue= 2 |pages= 119–21 |year= 2006 |pmid= 16189505 |doi= 10.1038/sj.mp.4001752 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{TAAR ligands}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
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[[Category:G protein-coupled receptors]]
 


{{WH}}
{{transmembranereceptor-stub}}
{{WS}}

Latest revision as of 05:13, 7 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[1][2]

Function

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[3][4]

References

  1. ↑ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
  2. ↑ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
  3. ↑ Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (October 2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". Am. J. Hum. Genet. 75 (4): 624–38. doi:10.1086/424887. PMC 1182049. PMID 15329799.
  4. ↑ "Entrez Gene: TAAR6 trace amine associated receptor 6".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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