5-HT1D receptor: Difference between revisions

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{{Wrongtitle|title=5-HT<sub>1D</sub> receptor}}
{{DISPLAYTITLE:5-HT<sub>1D</sub> receptor}}
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{{Infobox_gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''5-hydroxytryptamine (serotonin) receptor 1D''', also known as '''HTR1D''', is a [[5-HT receptor]], but also denotes the human [[gene]] encoding it.<ref name="entrez">{{cite web | title = Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3352| accessdate = }}</ref> 5-HT<sub>1D</sub> acts on the [[central nervous system]], and affects [[animal locomotion|locomotion]] and [[anxiety]]. It also induces vascular [[vasoconstriction]] in the brain.
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = 5-hydroxytryptamine (serotonin) receptor 1D
| HGNCid = 5289
| Symbol = HTR1D
| AltSymbols =; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
| OMIM = 182133
| ECnumber = 
| Homologene = 20240
| MGIid = 96276
| GeneAtlas_image1 = PBB_GE_HTR1D_207368_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004993 |text = serotonin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3352
    | Hs_Ensembl = ENSG00000179546
    | Hs_RefseqProtein = NP_000855
    | Hs_RefseqmRNA = NM_000864
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 23389580
    | Hs_GenLoc_end = 23393809
    | Hs_Uniprot = P28221
    | Mm_EntrezGene = 15552
    | Mm_Ensembl = ENSMUSG00000070687
    | Mm_RefseqmRNA = NM_008309
    | Mm_RefseqProtein = NP_032335
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 135695602
    | Mm_GenLoc_end = 135715840
    | Mm_Uniprot = Q3ZB48
  }}
}}
'''5-hydroxytryptamine (serotonin) receptor 1D''', also known as '''HTR1D''', is a [[5-HT receptor]], but also denotes the human [[gene]] encoding it.<ref name="entrez">{{cite web | title = Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3352| accessdate = }}</ref>


<!-- The PBB_Summary template is not automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
==Structure==
{{PBB_Summary
5HT<sub>1D</sub> receptor is a [[G protein]] linked receptor that activates an [[intracellular]] messenger cascade to produce an inhibitory response by decreasing cellular levels of cAMP.<ref name="Millan">Millan, M.J., et al., Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Trends in Pharmacological Sciences, 2008. 29(9): p. 454-464.</ref><ref name="Goadsby">Goadsby, P.J., Serotonin 5-HT<sub>1B/1D</sub> receptor agonists in migraine - Comparative pharmacology and its therapeutic implications. Cns Drugs, 1998. 10(4): p. 271-286.</ref> The 5HT<sub>1D</sub> is a [[G protein–coupled receptor|7-TM receptor]]. A large intercellular loop between TM-5 and TM-6 is believed to be associated with coupling to a second messenger. Agonists might bind in a manner that utilizes an [[aspartate]] residue in TM-3 and residues in the TM-4, TM-5 and TM-6.<ref name="Foyes">Lippincott, W. W., Lemke, T. L., Williams, D. A., Roche, V. F., & Zito, S. W. (2013). Foye's Principles of Medicinal Chemistry: Lippincott Williams & Wilkins: 368-376.</ref> A human clone containing an intronless open reading frame was found to encode 377 amino acids of the 5HT<sub>1D</sub> receptor. The gene has been localized on chromosome 1, region 1p34.3-36.3 <ref>{{cite journal | last1 = Jin | first1 = H. | last2 = Oksenberg | first2 = D. | last3 = Ashkenazi | first3 = A. | last4 = Peroutka | first4 = S. J. | last5 = Duncan | first5 = A. M. | last6 = Rozmahel | first6 = R. | last7 = O'Dowd | first7 = B. F. | year = 1992 | title = Characterization of the human 5-hydroxytryptamine1B receptor | url = | journal = J Biol Chem | volume = 267 | issue = 9| pages = 5735–5738 }}</ref><ref>{{cite journal | last1 = Weinshank | first1 = R. L. | last2 = Zgombick | first2 = J. M. | last3 = Macchi | first3 = M. J. | last4 = Branchek | first4 = T. A. | last5 = Hartig | first5 = P. R. | year = 1992 | title = Human Serotonin-1d Receptor Is Encoded by a Subfamily of 2 Distinct Genes - 5-Ht(1d-Alpha) and 5-Ht(1d-Beta) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 8| pages = 3630–3634 | doi = 10.1073/pnas.89.8.3630 | pmid=1565658 | pmc=48922}}</ref>
| section_title =  
| summary_text =  
}}


{| class="wikitable"
==Ligands==
! [[Agonist]]s
===Agonists===
! [[Receptor antagonist|Antagonist]]s
[[Molecular modelling]] has provided a picture of the [[agonistic]] binding site of 5HT<sub>1D</sub>. The [[amino acid]] residues within the receptor binding site region have been identified. This is a valuable guide to design potential 5HT<sub>1D</sub> receptor agonists.
|-
When [[sumatriptan]] binds there is major conformational change in both ligand and receptor in the binding pocket.<ref name="Bremner">{{cite journal | last1 = Bremner | first1 = D. H. | last2 = Ringan | first2 = N. S. | last3 = Wishart | first3 = G. | year = 1997 | title = Modeling of the agonist binding site of serotonin human 5-HT<sub>1A</sub>, 5-HT<sub>1Dα</sub> and 5-HT<sub>1Dβ</sub> receptors | url = | journal = European Journal of Medicinal Chemistry | volume = 32 | issue = 1| pages = 59–69 | doi = 10.1016/S0223-5234(97)84362-0 }}</ref>
|
*5-(Nonyloxy)[[tryptamine]],<ref name="Glennon_et_al_94">{{cite journal | author = Glennon RA, Hong SS, Dukat M, Teitler M, Davis K | title = 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT<sub>1D</sub> beta serotonin receptor agonist | journal = J. Med. Chem. | volume = 37 | issue = 18 | pages = 2828–30 | year = 1994 | pmid = 8071931 | doi = 10.1021/jm00044a001 | issn = }}</ref>  
* [[sumatriptan]] ([[vasoconstrictor]] in [[migraine]])
*''5-carboxamidotryptamine (5-CT)''
|
* [[Ziprasidone]] ([[atypical antipsychotic]]) [http://books.google.com/books?id=HkA0Q31YDhAC&pg=PA438&lpg=PA438&dq=antipsychotics+5ht1d&source=web&ots=dSBm26DKPf&sig=3GtDECBspZW7_O1y6zJHd04BFo8#PPA438,M1]
* [[methiothepin]] ([[antipsychotic]])
* [[yohimbine]] ([[aphrodisiac]])
* [[metergoline]]
* [[ergotamine]] ([[vasoconstrictor]] in [[migraine]])
|-
|}


5-HT<sub>1D</sub> acts on the CNS, and affects locomotion and anxiety. It also induces vascular [[vasoconstriction]] in the brain. Ergotamine works primarily through the 5-HT1B receptor, since the effect through the 5-HT1D receptor is contrary to the mode of action of ergotamine, i.e. vasoconstriction.
* [[Dextromethorphan]] ([[Cough Suppressant]])<ref>{{Cite journal|last=|first=|vauthors=Nguyen L, Thomas KL, Lucke-Wold BP, Cavendish JZ, Crowe MS, Matsumoto RR|date=|year=2016|title=Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders|url=|journal=Pharmacol. Ther.|volume=159|pages=1-22|via=}}</ref>
* [[5-(Nonyloxy)tryptamine]]<ref name="Glennon_et_al_94">{{cite journal | vauthors = Glennon RA, Hong SS, Dukat M, Teitler M, Davis K | title = 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist | journal = Journal of Medicinal Chemistry | volume = 37 | issue = 18 | pages = 2828–30 | date = Sep 1994 | pmid = 8071931 | doi = 10.1021/jm00044a001 }}</ref>
* [[Sumatriptan]] ([[vasoconstrictor]] in [[migraine]])
* [[5-Carboxamidotryptamine]] (5-CT)
* 5-(t-Butyl)-N-methyltryptamine<ref>{{cite journal | vauthors = Xu YC, Schaus JM, Walker C, Krushinski J, Adham N, Zgombick JM, Liang SX, Kohlman DT, Audia JE | title = N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist | journal = Journal of Medicinal Chemistry | volume = 42 | issue = 3 | pages = 526–31 | date = Feb 1999 | pmid = 9986723 | doi = 10.1021/jm9805945 }}</ref>
* [[CP-135,807]]
* CP-286,601
* PNU-109,291 ((S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide)
* PNU-142,633 ((1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide)
* GR-46611 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
* L-694,247 (2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine)
* L-772,405


==See also==
===Antagonists===
* [[Ziprasidone]] ([[atypical antipsychotic]]) [https://books.google.com/books?id=HkA0Q31YDhAC&pg=PA438&lpg=PA438&dq=antipsychotics+5ht1d&source=web&ots=dSBm26DKPf&sig=3GtDECBspZW7_O1y6zJHd04BFo8#PPA438,M1]
* [[Methiothepin]] ([[antipsychotic]])
* [[Yohimbine]] ([[aphrodisiac]])
* [[Metergoline]]
* [[Ergotamine]] ([[vasoconstrictor]] in [[migraine]])
* [[BRL-15572]]
* [[Vortioxetine]] ([[antidepressant]])
* GR-127,935 (mixed 5-HT<sub>1B/1D</sub> antagonist)
* [[LY-310,762]]
* LY-367,642
* LY-456,219
* LY-456,220
 
== See also ==
* [[5-HT1 receptor|5-HT<sub>1</sub> receptor]]
* [[5-HT1 receptor|5-HT<sub>1</sub> receptor]]
* [[5-HT receptor]]
* [[5-HT receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}


==Further reading==
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2314 | title = 5-HT<sub>1D</sub>  | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{UCSC gene info|HTR1D}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hamblin MW, Metcalf MA, McGuffin RW, Karpells S | title = Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity | journal = Biochemical and Biophysical Research Communications | volume = 184 | issue = 2 | pages = 752–9 | date = Apr 1992 | pmid = 1315531 | doi = 10.1016/0006-291X(92)90654-4 }}
| citations =
* {{cite journal | vauthors = Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR | title = Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 8 | pages = 3630–4 | date = Apr 1992 | pmid = 1565658 | pmc = 48922 | doi = 10.1073/pnas.89.8.3630 }}
*{{cite journal | author=Hamblin MW, Metcalf MA, McGuffin RW, Karpells S |title=Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 752-9 |year= 1992 |pmid= 1315531 |doi= }}
* {{cite journal | vauthors = Hamblin MW, Metcalf MA | title = Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor | journal = Molecular Pharmacology | volume = 40 | issue = 2 | pages = 143–8 | date = Aug 1991 | pmid = 1652050 | doi =  }}
*{{cite journal | author=Weinshank RL, Zgombick JM, Macchi MJ, ''et al.'' |title=Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3630-4 |year= 1992 |pmid= 1565658 |doi= }}
* {{cite journal | vauthors = Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG | title = Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor | journal = Genomics | volume = 11 | issue = 1 | pages = 225–7 | date = Sep 1991 | pmid = 1662665 | doi = 10.1016/0888-7543(91)90125-X }}
*{{cite journal | author=Hamblin MW, Metcalf MA |title=Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. |journal=Mol. Pharmacol. |volume=40 |issue= 2 |pages= 143-8 |year= 1991 |pmid= 1652050 |doi=  }}
* {{cite journal | vauthors = Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, Simons MJ, Dumont JE, Vassart G | title = Selective amplification and cloning of four new members of the G protein-coupled receptor family | journal = Science | volume = 244 | issue = 4904 | pages = 569–72 | date = May 1989 | pmid = 2541503 | doi = 10.1126/science.2541503 }}
*{{cite journal | author=Libert F, Passage E, Parmentier M, ''et al.'' |title=Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. |journal=Genomics |volume=11 |issue= 1 |pages= 225-7 |year= 1992 |pmid= 1662665 |doi= }}
* {{cite journal | vauthors = Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES | title = Characterization of single-nucleotide polymorphisms in coding regions of human genes | journal = Nature Genetics | volume = 22 | issue = 3 | pages = 231–8 | date = Jul 1999 | pmid = 10391209 | doi = 10.1038/10290 }}
*{{cite journal | author=Libert F, Parmentier M, Lefort A, ''et al.'' |title=Selective amplification and cloning of four new members of the G protein-coupled receptor family. |journal=Science |volume=244 |issue= 4904 |pages= 569-72 |year= 1989 |pmid= 2541503 |doi= }}
* {{cite journal | vauthors = Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC | title = Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15482–5 | date = May 2002 | pmid = 11854302 | doi = 10.1074/jbc.M201539200 }}
*{{cite journal | author=Cargill M, Altshuler D, Ireland J, ''et al.'' |title=Characterization of single-nucleotide polymorphisms in coding regions of human genes. |journal=Nat. Genet. |volume=22 |issue= 3 |pages= 231-8 |year= 1999 |pmid= 10391209 |doi= 10.1038/10290 }}
* {{cite journal | vauthors = Bergen AW, van den Bree MB, Yeager M, Welch R, Ganjei JK, Haque K, Bacanu S, Berrettini WH, Grice DE, Goldman D, Bulik CM, Klump K, Fichter M, Halmi K, Kaplan A, Strober M, Treasure J, Woodside B, Kaye WH | title = Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa | journal = Molecular Psychiatry | volume = 8 | issue = 4 | pages = 397–406 | date = Apr 2003 | pmid = 12740597 | doi = 10.1038/sj.mp.4001318 }}
*{{cite journal | author=Salim K, Fenton T, Bacha J, ''et al.'' |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482-5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200 }}
* {{cite journal | vauthors = Li J, Zhang X, Wang Y, Zhou R, Zhang H, Yang L, Wang B, Faraone SV | title = The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects | journal = American Journal of Medical Genetics Part B | volume = 141B | issue = 8 | pages = 874–6 | date = Dec 2006 | pmid = 17099886 | doi = 10.1002/ajmg.b.30364 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Bergen AW, van den Bree MB, Yeager M, ''et al.'' |title=Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. |journal=Mol. Psychiatry |volume=8 |issue= 4 |pages= 397-406 |year= 2004 |pmid= 12740597 |doi= 10.1038/sj.mp.4001318 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Li J, Zhang X, Wang Y, ''et al.'' |title=The serotonin 5-HT1D receptor gene and attention-deficit hyperactivity disorder in Chinese Han subjects. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=141 |issue= 8 |pages= 874-6 |year= 2007 |pmid= 17099886 |doi= 10.1002/ajmg.b.30364 }}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Serotonergics}}
{{Obsessive–compulsive disorder}}
 
{{DEFAULTSORT:5-Ht1d Receptor}}
[[Category:Serotonin receptors]]
 
 
{{transmembranereceptor-stub}}

Latest revision as of 00:25, 27 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.[1] 5-HT1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.

Structure

5HT1D receptor is a G protein linked receptor that activates an intracellular messenger cascade to produce an inhibitory response by decreasing cellular levels of cAMP.[2][3] The 5HT1D is a 7-TM receptor. A large intercellular loop between TM-5 and TM-6 is believed to be associated with coupling to a second messenger. Agonists might bind in a manner that utilizes an aspartate residue in TM-3 and residues in the TM-4, TM-5 and TM-6.[4] A human clone containing an intronless open reading frame was found to encode 377 amino acids of the 5HT1D receptor. The gene has been localized on chromosome 1, region 1p34.3-36.3 [5][6]

Ligands

Agonists

Molecular modelling has provided a picture of the agonistic binding site of 5HT1D. The amino acid residues within the receptor binding site region have been identified. This is a valuable guide to design potential 5HT1D receptor agonists. When sumatriptan binds there is major conformational change in both ligand and receptor in the binding pocket.[7]

Antagonists

See also

References

  1. ↑ "Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D".
  2. ↑ Millan, M.J., et al., Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Trends in Pharmacological Sciences, 2008. 29(9): p. 454-464.
  3. ↑ Goadsby, P.J., Serotonin 5-HT1B/1D receptor agonists in migraine - Comparative pharmacology and its therapeutic implications. Cns Drugs, 1998. 10(4): p. 271-286.
  4. ↑ Lippincott, W. W., Lemke, T. L., Williams, D. A., Roche, V. F., & Zito, S. W. (2013). Foye's Principles of Medicinal Chemistry: Lippincott Williams & Wilkins: 368-376.
  5. ↑ Jin, H.; Oksenberg, D.; Ashkenazi, A.; Peroutka, S. J.; Duncan, A. M.; Rozmahel, R.; O'Dowd, B. F. (1992). "Characterization of the human 5-hydroxytryptamine1B receptor". J Biol Chem. 267 (9): 5735–5738.
  6. ↑ Weinshank, R. L.; Zgombick, J. M.; Macchi, M. J.; Branchek, T. A.; Hartig, P. R. (1992). "Human Serotonin-1d Receptor Is Encoded by a Subfamily of 2 Distinct Genes - 5-Ht(1d-Alpha) and 5-Ht(1d-Beta)". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3630–3634. doi:10.1073/pnas.89.8.3630. PMC 48922. PMID 1565658.
  7. ↑ Bremner, D. H.; Ringan, N. S.; Wishart, G. (1997). "Modeling of the agonist binding site of serotonin human 5-HT1A, 5-HT1Dα and 5-HT1Dβ receptors". European Journal of Medicinal Chemistry. 32 (1): 59–69. doi:10.1016/S0223-5234(97)84362-0.
  8. ↑ Nguyen L, Thomas KL, Lucke-Wold BP, Cavendish JZ, Crowe MS, Matsumoto RR (2016). "Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders". Pharmacol. Ther. 159: 1–22.
  9. ↑ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (Sep 1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist". Journal of Medicinal Chemistry. 37 (18): 2828–30. doi:10.1021/jm00044a001. PMID 8071931.
  10. ↑ Xu YC, Schaus JM, Walker C, Krushinski J, Adham N, Zgombick JM, Liang SX, Kohlman DT, Audia JE (Feb 1999). "N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist". Journal of Medicinal Chemistry. 42 (3): 526–31. doi:10.1021/jm9805945. PMID 9986723.

External links

  • "5-HT1D". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  • Human HTR1D genome location and HTR1D gene details page in the UCSC Genome Browser.

Further reading

  • Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (Apr 1992). "Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity". Biochemical and Biophysical Research Communications. 184 (2): 752–9. doi:10.1016/0006-291X(92)90654-4. PMID 1315531.
  • Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR (Apr 1992). "Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta". Proceedings of the National Academy of Sciences of the United States of America. 89 (8): 3630–4. doi:10.1073/pnas.89.8.3630. PMC 48922. PMID 1565658.
  • Hamblin MW, Metcalf MA (Aug 1991). "Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor". Molecular Pharmacology. 40 (2): 143–8. PMID 1652050.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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