CELSR1: Difference between revisions
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'''Cadherin EGF LAG seven-pass G-type receptor 1''' also known as '''flamingo homolog 2''' or '''cadherin family member 9''' is a [[protein]] that in humans is encoded by the ''CELSR1'' [[gene]].<ref name="pmid9339365">{{cite journal | vauthors = Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF | title = Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter | journal = Genomics | volume = 45 | issue = 1 | pages = 97–104 |date=Nov 1997 | pmid = 9339365 | pmc = | doi = 10.1006/geno.1997.4892 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620| accessdate = }}</ref> | |||
== Function == | |||
The protein encoded by this gene is a member of the flamingo subfamily, part of the [[cadherin]] superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with [[catenin]]s. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two [[laminin]] G-like domains in their [[ectodomain]]. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the [[epidermal growth factor|EGF]]-like domains involved in [[cell adhesion]] and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.<ref name="entrez" /> | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CELSR1}} | |||
* {{UCSC gene info|ME2}} | |||
==Further reading== | ==Further reading== | ||
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*{{cite journal | | *{{cite journal | vauthors=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes |journal=Cell |volume=97 |issue= 6 |pages= 779–90 |year= 1999 |pmid= 10380929 |doi=10.1016/S0092-8674(00)80789-8 }} | ||
*{{cite journal | vauthors=Dunham I, Shimizu N, Roe BA |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397 | pmc=16203 }} | ||
*{{cite journal | | *{{cite journal | author=Ghosh A |title=Dentritic{{sic|nolink=y}} growth: don't go says flamingo |journal=Neuron |volume=28 |issue= 1 |pages= 3–4 |year= 2000 |pmid= 11086974 |doi=10.1016/S0896-6273(00)00076-3 }} | ||
*{{cite journal | author=Ghosh A |title=Dentritic growth: don't go says flamingo | *{{cite journal | vauthors=Gross J, Grimm O, Ortega G |title=Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family |journal=Psychiatr. Genet. |volume=11 |issue= 4 |pages= 197–200 |year= 2002 |pmid= 11807409 |doi=10.1097/00041444-200112000-00003 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Georgieva L, Nikolov I, Poriazova N |title=Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia |journal=Psychiatr. Genet. |volume=13 |issue= 2 |pages= 103–6 |year= 2004 |pmid= 12782967 |doi= 10.1097/01.ypg.0000057486.14812.03 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Carroll JS, Liu XS, Brodsky AS |title=Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1 |journal=Cell |volume=122 |issue= 1 |pages= 33–43 |year= 2005 |pmid= 16009131 |doi= 10.1016/j.cell.2005.05.008 |display-authors=etal}} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{NLM content}} | {{NLM content}} | ||
{{ | {{G protein-coupled receptors}} | ||
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[[Category:Adhesion GPCRs]] | [[Category:Adhesion GPCRs]] | ||
[[Category:Chemokine receptors]] | [[Category:Chemokine receptors]] | ||
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Latest revision as of 09:32, 30 August 2017
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Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.[1][2]
Function
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[2]
See also
References
- ↑ Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter". Genomics. 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID 9339365.
- ↑ 2.0 2.1 "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)".
External links
- Human CELSR1 genome location and CELSR1 gene details page in the UCSC Genome Browser.
- Human ME2 genome location and ME2 gene details page in the UCSC Genome Browser.
Further reading
- Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
- Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
- Ghosh A (2000). "Dentritic [sic] growth: don't go says flamingo". Neuron. 28 (1): 3–4. doi:10.1016/S0896-6273(00)00076-3. PMID 11086974.
- Gross J, Grimm O, Ortega G, et al. (2002). "Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family". Psychiatr. Genet. 11 (4): 197–200. doi:10.1097/00041444-200112000-00003. PMID 11807409.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Georgieva L, Nikolov I, Poriazova N, et al. (2004). "Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia". Psychiatr. Genet. 13 (2): 103–6. doi:10.1097/01.ypg.0000057486.14812.03. PMID 12782967.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Carroll JS, Liu XS, Brodsky AS, et al. (2005). "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1". Cell. 122 (1): 33–43. doi:10.1016/j.cell.2005.05.008. PMID 16009131.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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