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{{Infobox_gene}}
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'''G protein-coupled receptor 6''', also known as '''GPR6''', is a [[protein]] which in humans is encoded by the ''GPR6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR6 G protein-coupled receptor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2830| accessdate = }}</ref><ref name="pmid8530049">{{cite journal |vauthors=Song ZH, Modi W, Bonner TI | title = Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors | journal = Genomics | volume = 28 | issue = 2 | pages = 347–9 |date=July 1995 | pmid = 8530049 | doi = 10.1006/geno.1995.1154 | url =  }}</ref>
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== Function ==
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GPR6 is a member of the [[G protein-coupled receptor]] family of [[transmembrane receptor]]s. It has been reported that GPR6 is both constitutively active but in addition is further activated by [[sphingosine-1-phosphate]].<ref name="pmid12220620">{{cite journal |vauthors=Uhlenbrock K, Gassenhuber H, Kostenis E | title = Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors | journal = Cellular Signalling | volume = 14 | issue = 11 | pages = 941–53 |date=November 2002 | pmid = 12220620 | doi = 10.1016/S0898-6568(02)00041-4 | url = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
GPR6 up-regulates [[Cyclic adenosine monophosphate|cyclic AMP]] levels and promotes [[neurite]] outgrowth.<ref name="pmid17284443">{{cite journal |vauthors=Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y | title = Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth | journal = The Journal of Biological Chemistry | volume = 282 | issue = 14 | pages = 10506–15 |date=April 2007 | pmid = 17284443 | doi = 10.1074/jbc.M700911200 | url = }}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = G protein-coupled receptor 6
| HGNCid = 4515
| Symbol = GPR6
| AltSymbols =;
| OMIM = 600553
| ECnumber = 
| Homologene = 38026
| MGIid = 2155249
| GeneAtlas_image1 = PBB_GE_GPR6_214655_at_tn.png
| Function = {{GNF_GO|id=GO:0001619 |text = lysosphingolipid and lysophosphatidic acid receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2830
    | Hs_Ensembl = ENSG00000146360
    | Hs_RefseqProtein = NP_005275
    | Hs_RefseqmRNA = NM_005284
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 110406991
    | Hs_GenLoc_end = 110408614
    | Hs_Uniprot = P46095
    | Mm_EntrezGene = 140741
    | Mm_Ensembl = ENSMUSG00000046922
    | Mm_RefseqmRNA = NM_199058
    | Mm_RefseqProtein = NP_951013
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 40758908
    | Mm_GenLoc_end = 40759999
    | Mm_Uniprot = Q2M2N8
  }}
}}
'''G protein-coupled receptor 6''', also known as '''GPR6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR6 G protein-coupled receptor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2830| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{PBB_Summary
* [[Lysophospholipid receptor]]
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Heiber M, Docherty JM, Shah G, ''et al.'' |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25-35 |year= 1995 |pmid= 7832990 |doi=  }}
*{{cite journal   |vauthors=Heiber M, Docherty JM, Shah G, etal |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25–35 |year= 1995 |pmid= 7832990 |doi=10.1089/dna.1995.14.25 }}
*{{cite journal  | author=Song ZH, Modi W, Bonner TI |title=Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. |journal=Genomics |volume=28 |issue= 2 |pages= 347-9 |year= 1996 |pmid= 8530049 |doi= 10.1006/geno.1995.1154 }}
*{{cite journal  |vauthors=Song ZH, Modi W, Bonner TI |title=Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. |journal=Genomics |volume=28 |issue= 2 |pages= 347–9 |year= 1996 |pmid= 8530049 |doi= 10.1006/geno.1995.1154 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Uhlenbrock K, Huber J, Ardati A, ''et al.'' |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75-84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 }}
*{{cite journal   |vauthors=Uhlenbrock K, Huber J, Ardati A, etal |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75–84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3091 | title = GPR6  | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
 
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
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[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 18:00, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[1][2]

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[3]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[4]

See also

References

  1. ↑ "Entrez Gene: GPR6 G protein-coupled receptor 6".
  2. ↑ Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
  3. ↑ Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–53. doi:10.1016/S0898-6568(02)00041-4. PMID 12220620.
  4. ↑ Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–15. doi:10.1074/jbc.M700911200. PMID 17284443.

Further reading

External links

  • "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Retrieved from "https://www.wikidoc.org/index.php?title=GPR6&oldid=1533192"