Neuropeptides B/W receptor 2: Difference between revisions

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{{Infobox_gene}}
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'''Neuropeptides B/W receptor 2''', also known as '''NPBW2''', is a human [[protein]] encoded by the '''NPBWR2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPBWR2 neuropeptides B/W receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2832| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Neuropeptides B/W receptor 2
| HGNCid = 4530
| Symbol = NPBWR2
| AltSymbols =; GPR8
| OMIM = 600731
| ECnumber = 
| Homologene = 48336
| MGIid = 
| GeneAtlas_image1 = PBB_GE_NPBWR2_221358_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004985 |text = opioid receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2832
    | Hs_Ensembl = ENSG00000125522
    | Hs_RefseqProtein = NP_005277
    | Hs_RefseqmRNA = NM_005286
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 62207617
    | Hs_GenLoc_end = 62208968
    | Hs_Uniprot = P48146
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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'''Neuropeptides B/W receptor 2''', also known as '''NPBWR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NPBWR2 neuropeptides B/W receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2832| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.<ref name="entrez">{{cite web | title = Entrez Gene: NPBWR2 neuropeptides B/W receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2832| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3003 | title = Neuropeptide B/W Receptors: NPBW2 | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=O'Dowd BF, Scheideler MA, Nguyen T, ''et al.'' |title=The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain. |journal=Genomics |volume=28 |issue= 1 |pages= 84-91 |year= 1995 |pmid= 7590751 |doi=  }}
*{{cite journal   |vauthors=O'Dowd BF, Scheideler MA, Nguyen T, etal |title=The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain |journal=Genomics |volume=28 |issue= 1 |pages= 84–91 |year= 1995 |pmid= 7590751 |doi=10.1006/geno.1995.1109 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Shimomura Y, Harada M, Goto M, ''et al.'' |title=Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35826-32 |year= 2002 |pmid= 12130646 |doi= 10.1074/jbc.M205337200 }}
*{{cite journal   |vauthors=Shimomura Y, Harada M, Goto M, etal |title=Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8 |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35826–32 |year= 2002 |pmid= 12130646 |doi= 10.1074/jbc.M205337200 }}
*{{cite journal | author=Brezillon S, Lannoy V, Franssen JD, ''et al.'' |title=Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 776-83 |year= 2003 |pmid= 12401809 |doi= 10.1074/jbc.M206396200 }}
*{{cite journal   |vauthors=Brezillon S, Lannoy V, Franssen JD, etal |title=Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8 |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 776–83 |year= 2003 |pmid= 12401809 |doi= 10.1074/jbc.M206396200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Tanaka H, Yoshida T, Miyamoto N, ''et al.'' |title=Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 6251-6 |year= 2003 |pmid= 12719537 |doi= 10.1073/pnas.0837789100 }}
*{{cite journal   |vauthors=Tanaka H, Yoshida T, Miyamoto N, etal |title=Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 6251–6 |year= 2003 |pmid= 12719537 |doi= 10.1073/pnas.0837789100 | pmc=156358 }}
*{{cite journal | author=Mazzocchi G, Rebuffat P, Ziolkowska A, ''et al.'' |title=G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 6 |pages= 3466-71 |year= 2005 |pmid= 15797961 |doi= 10.1210/jc.2004-2132 }}
*{{cite journal   |vauthors=Mazzocchi G, Rebuffat P, Ziolkowska A, etal |title=G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 6 |pages= 3466–71 |year= 2005 |pmid= 15797961 |doi= 10.1210/jc.2004-2132 }}
}}
}}
{{refend}}
{{refend}}


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{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
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{{DEFAULTSORT:Neuropeptides B W receptor 2}}
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 07:15, 10 January 2019

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Neuropeptides B/W receptor 2, also known as NPBW2, is a human protein encoded by the NPBWR2 gene.[1]

The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: NPBWR2 neuropeptides B/W receptor 2".

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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