P2RY1: Difference between revisions

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{{Infobox_gene}}
'''P2Y purinoceptor 1''' is a [[protein]] that in humans is encoded by the ''P2RY1'' [[gene]].<ref name="pmid8579591">{{cite journal | vauthors = Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP | title = Cloning and chromosomal localization of the human P2Y1 purinoceptor | journal = Biochemical and Biophysical Research Communications | volume = 218 | issue = 3 | pages = 783–8 | date = January 1996 | pmid = 8579591 | pmc =  | doi = 10.1006/bbrc.1996.0139 }}</ref>


== Function ==


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
The product of this gene, P2Y<sub>1</sub> belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5028| accessdate = }}</ref>
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Purinergic receptor P2Y, G-protein coupled, 1
| HGNCid = 8539
| Symbol = P2RY1
| AltSymbols =; P2Y1
| OMIM = 601167
| ECnumber = 
| Homologene = 1926
| MGIid = 105049
| GeneAtlas_image1 = PBB_GE_P2RY1_207455_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5028
    | Hs_Ensembl = ENSG00000169860
    | Hs_RefseqProtein = NP_002554
    | Hs_RefseqmRNA = NM_002563
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 154035426
    | Hs_GenLoc_end = 154038531
    | Hs_Uniprot = P47900
    | Mm_EntrezGene = 18441
    | Mm_Ensembl = ENSMUSG00000027765
    | Mm_RefseqmRNA = NM_008772
    | Mm_RefseqProtein = NP_032798
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 61090724
    | Mm_GenLoc_end = 61096908
    | Mm_Uniprot = Q544J5
  }}
}}
'''Purinergic receptor P2Y, G-protein coupled, 1''', also known as '''P2RY1''', is a human [[gene]].
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5028| accessdate = }}</ref>
}}
 
==See also==
* [[P2Y receptor]]
* [[P2Y receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM | title = Cloning and tissue distribution of the human P2Y1 receptor | journal = Biochemical and Biophysical Research Communications | volume = 221 | issue = 3 | pages = 588–93 | date = April 1996 | pmid = 8630005 | doi = 10.1006/bbrc.1996.0640 }}
| citations =
* {{cite journal | vauthors = Léon C, Vial C, Cazenave JP, Gachet C | title = Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor | journal = Gene | volume = 171 | issue = 2 | pages = 295–7 | date = June 1996 | pmid = 8666290 | doi = 10.1016/0378-1119(96)00027-3 }}
*{{cite journal | author=Ayyanathan K, Webbs TE, Sandhu AK, ''et al.'' |title=Cloning and chromosomal localization of the human P2Y1 purinoceptor. |journal=Biochem. Biophys. Res. Commun. |volume=218 |issue= 3 |pages= 783-8 |year= 1996 |pmid= 8579591 |doi= 10.1006/bbrc.1996.0139 }}
* {{cite journal | vauthors = Léon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C | title = The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells | journal = FEBS Letters | volume = 403 | issue = 1 | pages = 26–30 | date = February 1997 | pmid = 9038354 | doi = 10.1016/S0014-5793(97)00022-7 }}
*{{cite journal | author=Janssens R, Communi D, Pirotton S, ''et al.'' |title=Cloning and tissue distribution of the human P2Y1 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=221 |issue= 3 |pages= 588-93 |year= 1996 |pmid= 8630005 |doi= 10.1006/bbrc.1996.0640 }}
* {{cite journal | vauthors = Ayyanathan K, Naylor SL, Kunapuli SP | title = Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1) | journal = Somatic Cell and Molecular Genetics | volume = 22 | issue = 5 | pages = 419–24 | date = September 1996 | pmid = 9039850 | doi = 10.1007/BF02369897 }}
*{{cite journal | author=Léon C, Vial C, Cazenave JP, Gachet C |title=Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. |journal=Gene |volume=171 |issue= 2 |pages= 295-7 |year= 1996 |pmid= 8666290 |doi= }}
* {{cite journal | vauthors = Maier R, Glatz A, Mosbacher J, Bilbe G | title = Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues | journal = Biochemical and Biophysical Research Communications | volume = 237 | issue = 2 | pages = 297–302 | date = August 1997 | pmid = 9268704 | doi = 10.1006/bbrc.1997.7135 }}
*{{cite journal | author=Léon C, Hechler B, Vial C, ''et al.'' |title=The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. |journal=FEBS Lett. |volume=403 |issue= 1 |pages= 26-30 |year= 1997 |pmid= 9038354 |doi= }}
* {{cite journal | vauthors = Jin J, Daniel JL, Kunapuli SP | title = Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2030–4 | date = January 1998 | pmid = 9442040 | doi = 10.1074/jbc.273.4.2030 }}
*{{cite journal | author=Ayyanathan K, Naylor SL, Kunapuli SP |title=Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1). |journal=Somat. Cell Mol. Genet. |volume=22 |issue= 5 |pages= 419-24 |year= 1997 |pmid= 9039850 |doi= }}
* {{cite journal | vauthors = Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ | title = A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8496–501 | date = July 1998 | pmid = 9671706 | pmc = 21104 | doi = 10.1073/pnas.95.15.8496 }}
*{{cite journal | author=Maier R, Glatz A, Mosbacher J, Bilbe G |title=Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 2 |pages= 297-302 |year= 1997 |pmid= 9268704 |doi= 10.1006/bbrc.1997.7135 }}
* {{cite journal | vauthors = Sabala P, Czajkowski R, Przybyłek K, Kalita K, Kaczmarek L, Barańska J | title = Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells | journal = British Journal of Pharmacology | volume = 132 | issue = 2 | pages = 393–402 | date = January 2001 | pmid = 11159687 | pmc = 1572584 | doi = 10.1038/sj.bjp.0703843 }}
*{{cite journal | author=Jin J, Daniel JL, Kunapuli SP |title=Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2030-4 |year= 1998 |pmid= 9442040 |doi= }}
* {{cite journal | vauthors = Yoshioka K, Saitoh O, Nakata H | title = Heteromeric association creates a P2Y-like adenosine receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7617–22 | date = June 2001 | pmid = 11390975 | pmc = 34717 | doi = 10.1073/pnas.121587098 }}
*{{cite journal | author=Hall RA, Ostedgaard LS, Premont RT, ''et al.'' |title=A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8496-501 |year= 1998 |pmid= 9671706 |doi= }}
* {{cite journal | vauthors = James G, Butt AM | title = Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve | journal = Neuroscience Letters | volume = 312 | issue = 1 | pages = 33–6 | date = October 2001 | pmid = 11578839 | doi = 10.1016/S0304-3940(01)02189-9 }}
*{{cite journal | author=Sabala P, Czajkowski R, Przybyłek K, ''et al.'' |title=Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells. |journal=Br. J. Pharmacol. |volume=132 |issue= 2 |pages= 393-402 |year= 2001 |pmid= 11159687 |doi= 10.1038/sj.bjp.0703843 }}
* {{cite journal | vauthors = Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR | title = Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study | journal = Biochimica et Biophysica Acta | volume = 1521 | issue = 1-3 | pages = 107–19 | date = October 2001 | pmid = 11690642 | doi = 10.1016/S0167-4781(01)00291-3 }}
*{{cite journal | author=Yoshioka K, Saitoh O, Nakata H |title=Heteromeric association creates a P2Y-like adenosine receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7617-22 |year= 2001 |pmid= 11390975 |doi= 10.1073/pnas.121587098 }}
* {{cite journal | vauthors = Czajkowski R, Lei L, Sabała P, Barańska J | title = ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12) | journal = FEBS Letters | volume = 513 | issue = 2-3 | pages = 179–83 | date = February 2002 | pmid = 11904146 | doi = 10.1016/S0014-5793(02)02255-X }}
*{{cite journal | author=James G, Butt AM |title=Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve. |journal=Neurosci. Lett. |volume=312 |issue= 1 |pages= 33-6 |year= 2001 |pmid= 11578839 |doi= }}
* {{cite journal | vauthors = Aktas B, Hönig-Liedl P, Walter U, Geiger J | title = Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase | journal = Biochemical Pharmacology | volume = 64 | issue = 3 | pages = 433–9 | date = August 2002 | pmid = 12147294 | doi = 10.1016/S0006-2952(02)01113-9 }}
*{{cite journal | author=Moore DJ, Chambers JK, Wahlin JP, ''et al.'' |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1-3 |pages= 107-19 |year= 2001 |pmid= 11690642 |doi= }}
* {{cite journal | vauthors = Nurden P, Poujol C, Winckler J, Combrié R, Pousseau N, Conley PB, Levy-Toledano S, Habib A, Nurden AT | title = Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system | journal = Blood | volume = 101 | issue = 4 | pages = 1400–8 | date = February 2003 | pmid = 12393588 | doi = 10.1182/blood-2002-02-0642 }}
*{{cite journal | author=Czajkowski R, Lei L, Sabała P, Barańska J |title=ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12). |journal=FEBS Lett. |volume=513 |issue= 2-3 |pages= 179-83 |year= 2002 |pmid= 11904146 |doi= }}
* {{cite journal | vauthors = Burrell HE, Bowler WB, Gallagher JA, Sharpe GR | title = Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 3 | pages = 440–7 | date = March 2003 | pmid = 12603858 | doi = 10.1046/j.1523-1747.2003.12050.x }}
*{{cite journal | author=Aktas B, Hönig-Liedl P, Walter U, Geiger J |title=Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase. |journal=Biochem. Pharmacol. |volume=64 |issue= 3 |pages= 433-9 |year= 2002 |pmid= 12147294 |doi= }}
* {{cite journal | vauthors = Jagroop IA, Burnstock G, Mikhailidis DP | title = Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets | journal = Platelets | volume = 14 | issue = 1 | pages = 15–20 | date = February 2003 | pmid = 12623443 | doi = 10.1080/0953710021000062914 }}
*{{cite journal | author=Nurden P, Poujol C, Winckler J, ''et al.'' |title=Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system. |journal=Blood |volume=101 |issue= 4 |pages= 1400-8 |year= 2003 |pmid= 12393588 |doi= 10.1182/blood-2002-02-0642 }}
* {{cite journal | vauthors = Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G | title = Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 6 | pages = 1007–15 | date = June 2003 | pmid = 12787128 | doi = 10.1046/j.1523-1747.2003.12261.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wang L, Ostberg O, Wihlborg AK, Brogren H, Jern S, Erlinge D | title = Quantification of ADP and ATP receptor expression in human platelets | journal = Journal of Thrombosis and Haemostasis | volume = 1 | issue = 2 | pages = 330–6 | date = February 2003 | pmid = 12871508 | doi = 10.1046/j.1538-7836.2003.00070.x }}
*{{cite journal | author=Burrell HE, Bowler WB, Gallagher JA, Sharpe GR |title=Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. |journal=J. Invest. Dermatol. |volume=120 |issue= 3 |pages= 440-7 |year= 2003 |pmid= 12603858 |doi= 10.1046/j.1523-1747.2003.12050.x }}
*{{cite journal | author=Jagroop IA, Burnstock G, Mikhailidis DP |title=Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets. |journal=Platelets |volume=14 |issue= 1 |pages= 15-20 |year= 2003 |pmid= 12623443 |doi= }}
*{{cite journal  | author=Greig AV, Linge C, Terenghi G, ''et al.'' |title=Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1007-15 |year= 2003 |pmid= 12787128 |doi=  }}
*{{cite journal  | author=Wang L, Ostberg O, Wihlborg AK, ''et al.'' |title=Quantification of ADP and ATP receptor expression in human platelets. |journal=J. Thromb. Haemost. |volume=1 |issue= 2 |pages= 330-6 |year= 2003 |pmid= 12871508 |doi=  }}
}}
{{refend}}
{{refend}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2392 | title = P2Y Receptors: P2Y<sub>1</sub> | accessdate = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Purinergics}}


{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

Function

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

See also

References

  1. ↑ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochemical and Biophysical Research Communications. 218 (3): 783–8. doi:10.1006/bbrc.1996.0139. PMID 8579591.
  2. ↑ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".

Further reading

External links

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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