TAS2R8: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Taste receptor type 2 member 8''' is a [[protein]] that in humans is encoded by the ''TAS2R8'' [[gene]].<ref name="pmid10761934">{{cite journal | vauthors = Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS | title = A novel family of mammalian taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 693–702 | date = Apr 2000 | pmid = 10761934 | pmc =  | doi = 10.1016/S0092-8674(00)80705-9 }}</ref><ref name="pmid10766242">{{cite journal | vauthors = Matsunami H, Montmayeur JP, Buck LB | title = A family of candidate taste receptors in human and mouse | journal = Nature | volume = 404 | issue = 6778 | pages = 601–4 | date = Apr 2000 | pmid = 10766242 | pmc = | doi = 10.1038/35007072 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAS2R8 taste receptor, type 2, member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50836| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Taste receptor, type 2, member 8
| HGNCid = 14915
| Symbol = TAS2R8
| AltSymbols =; T2R8; TRB5
| OMIM = 604794
| ECnumber = 
| Homologene = 88894
| MGIid = 
| GeneAtlas_image1 = PBB_GE_TAS2R8_221398_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008527 |text = taste receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} {{GNF_GO|id=GO:0050909 |text = sensory perception of taste}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 50836
    | Hs_Ensembl = ENSG00000121314
    | Hs_RefseqProtein = NP_076407
    | Hs_RefseqmRNA = NM_023918
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 10849917
    | Hs_GenLoc_end = 10850846
    | Hs_Uniprot = Q9NYW2
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Taste receptor, type 2, member 8''', also known as '''TAS2R8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R8 taste receptor, type 2, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50836| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene product belongs to the family of candidate [[taste receptor]]s that are members of the [[G-protein-coupled receptor]] superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.<ref name="entrez">{{cite web | title = Entrez Gene: TAS2R8 taste receptor, type 2, member 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50836| accessdate = }}</ref>
}}


==See also==
==See also==
Line 58: Line 10:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | author = Kinnamon SC | title = A plethora of taste receptors | journal = Neuron | volume = 25 | issue = 3 | pages = 507–10 | year = 2000 | pmid = 10774719 | doi = 10.1016/S0896-6273(00)81054-5 }}
| citations =
*{{cite journal | author = Margolskee RF | title = Molecular mechanisms of bitter and sweet taste transduction | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 1–4 | year = 2002 | pmid = 11696554 | doi = 10.1074/jbc.R100054200 }}
*{{cite journal | author=Kinnamon SC |title=A plethora of taste receptors. |journal=Neuron |volume=25 |issue= 3 |pages= 507-10 |year= 2000 |pmid= 10774719 |doi= }}
*{{cite journal | vauthors = Montmayeur JP, Matsunami H | title = Receptors for bitter and sweet taste | journal = Curr. Opin. Neurobiol. | volume = 12 | issue = 4 | pages = 366–71 | year = 2002 | pmid = 12139982 | doi = 10.1016/S0959-4388(02)00345-8 }}
*{{cite journal | author=Margolskee RF |title=Molecular mechanisms of bitter and sweet taste transduction. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 1-4 |year= 2002 |pmid= 11696554 |doi= 10.1074/jbc.R100054200 }}
*{{cite journal | vauthors = Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ | title = T2Rs function as bitter taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 703–11 | year = 2000 | pmid = 10761935 | doi = 10.1016/S0092-8674(00)80706-0 }}
*{{cite journal | author=Montmayeur JP, Matsunami H |title=Receptors for bitter and sweet taste. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 4 |pages= 366-71 |year= 2002 |pmid= 12139982 |doi= }}
*{{cite journal | vauthors = Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ | title = Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways | journal = Cell | volume = 112 | issue = 3 | pages = 293–301 | year = 2003 | pmid = 12581520 | doi = 10.1016/S0092-8674(03)00071-0 }}
*{{cite journal  | author=Adler E, Hoon MA, Mueller KL, ''et al.'' |title=A novel family of mammalian taste receptors. |journal=Cell |volume=100 |issue= 6 |pages= 693-702 |year= 2000 |pmid= 10761934 |doi=  }}
*{{cite journal | vauthors = Fischer A, Gilad Y, Man O, Pääbo S | title = Evolution of bitter taste receptors in humans and apes | journal = Mol. Biol. Evol. | volume = 22 | issue = 3 | pages = 432–6 | year = 2005 | pmid = 15496549 | doi = 10.1093/molbev/msi027 }}
*{{cite journal | author=Chandrashekar J, Mueller KL, Hoon MA, ''et al.'' |title=T2Rs function as bitter taste receptors. |journal=Cell |volume=100 |issue= 6 |pages= 703-11 |year= 2000 |pmid= 10761935 |doi=  }}
*{{cite journal | vauthors = Go Y, Satta Y, Takenaka O, Takahata N | title = Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates | journal = Genetics | volume = 170 | issue = 1 | pages = 313–26 | year = 2006 | pmid = 15744053 | pmc = 1449719 | doi = 10.1534/genetics.104.037523 }}
*{{cite journal  | author=Matsunami H, Montmayeur JP, Buck LB |title=A family of candidate taste receptors in human and mouse. |journal=Nature |volume=404 |issue= 6778 |pages= 601-4 |year= 2000 |pmid= 10766242 |doi= 10.1038/35007072 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Zhang Y, Hoon MA, Chandrashekar J, ''et al.'' |title=Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. |journal=Cell |volume=112 |issue= 3 |pages= 293-301 |year= 2003 |pmid= 12581520 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Fischer A, Gilad Y, Man O, Pääbo S |title=Evolution of bitter taste receptors in humans and apes. |journal=Mol. Biol. Evol. |volume=22 |issue= 3 |pages= 432-6 |year= 2005 |pmid= 15496549 |doi= 10.1093/molbev/msi027 }}
*{{cite journal | author=Go Y, Satta Y, Takenaka O, Takahata N |title=Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. |journal=Genetics |volume=170 |issue= 1 |pages= 313-26 |year= 2006 |pmid= 15744053 |doi= 10.1534/genetics.104.037523 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g3}}
[[Category:G protein coupled receptors]]
 
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[[Category:G protein-coupled receptors]]
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{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.[1][2][3]

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]

See also

References

  1. ↑ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
  2. ↑ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.
  3. ↑ 3.0 3.1 "Entrez Gene: TAS2R8 taste receptor, type 2, member 8".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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