CELSR2: Difference between revisions
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==Further reading== | ==Further reading== | ||
Revision as of 15:03, 4 September 2012
| Cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CELSR2 ; CDHF10; EGFL2; FLJ34118; FLJ42737; FLJ45143; FLJ45845; Flamingo1; KIAA0279; MEGF3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1078 | ||||||||||
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| RNA expression pattern | |||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila), also known as CELSR2, is a human gene.[1]
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.[1]
See also
References
Further reading
- Nagase T, Seki N, Ishikawa K; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
- Nakayama M, Nakajima D, Nagase T; et al. (1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
- Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. PMID 10380929.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMID 10716726.
- Vincent JB, Skaug J, Scherer SW (2001). "The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1". DNA Res. 7 (3): 233–5. PMID 10907856.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.