Bombesin-like receptor 3: Difference between revisions

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{{Infobox_gene}}
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The '''bombesin receptor subtype 3''' also known as '''BRS-3''' or '''BB<sub>3</sub>'''<ref name="IUPHAR-DB">{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 | title = Bombesin Receptors: BB<sub>3</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}</ref> is a [[protein]] which in humans is encoded by the ''BRS3'' [[gene]].<ref name="pmid8383682">{{cite journal | vauthors = Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF | title = BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells | journal = J. Biol. Chem. | volume = 268 | issue = 8 | pages = 5979–84 |date=March 1993 | pmid = 8383682 | doi = | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=8383682 | issn = }}</ref><ref name="pmid9262170">{{cite journal | vauthors = Ohki-Hamazaki H, Wada E, Matsui K, Wada K | title = Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse | journal = Brain Res. | volume = 762 | issue = 1-2 | pages = 165–72 |date=July 1997 | pmid = 9262170 | doi = 10.1016/S0006-8993(97)00380-6| url = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Bombesin-like receptor 3
| HGNCid = 1113
| Symbol = BRS3
| AltSymbols =;
| OMIM = 300107
| ECnumber = 
| Homologene = 1307
| MGIid = 1100501
| GeneAtlas_image1 = PBB_GE_BRS3_207369_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004946 |text = bombesin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0008343 |text = adult feeding behavior}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 680
    | Hs_Ensembl = ENSG00000102239
    | Hs_RefseqProtein = NP_001718
    | Hs_RefseqmRNA = NM_001727
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 135397712
    | Hs_GenLoc_end = 135403605
    | Hs_Uniprot = P32247
    | Mm_EntrezGene = 12209
    | Mm_Ensembl = ENSMUSG00000031130
    | Mm_RefseqmRNA = NM_009766
    | Mm_RefseqProtein = NP_033896
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 53389858
    | Mm_GenLoc_end = 53395542
    | Mm_Uniprot = O54798
  }}
}}


The '''bombesin-like receptor 3''' ('''BRS-3''') is a [[G protein-coupled receptor]].<ref name="pmid8383682">{{cite journal | author = Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF | title = BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells | journal = J. Biol. Chem. | volume = 268 | issue = 8 | pages = 5979-84 | year = 1993 | pmid = 8383682 | doi = | issn = | url = http://www.jbc.org/cgi/content/abstract/268/8/5979}}</ref> As no [[endogenous]] ligand has been identified for BRS-3, it is classified as an [[orphan receptor]].
Mammalian [[bombesin]]-like peptides are widely distributed in the [[central nervous system]] as well as in the [[gastrointestinal tract]], where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include [[gastrin-releasing peptide receptor]], [[neuromedin B receptor]], and bombesin-like receptor-3 (BRS3; this article).<ref name="pmid9262170"/><ref name="entrez">{{cite web | title = Entrez Gene: BRS3 bombesin-like receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=680| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
BB<sub>3</sub> is a [[G protein-coupled receptor]].<ref name="pmid8383682" /> BB<sub>3</sub> only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an [[orphan receptor]].<ref name="pmid8383682" /><ref name="pmid9325344">{{cite journal | vauthors = Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH, Jensen RT | last-author-amp = yes | title = Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors. | journal = J. Biol. Chem. | volume = 272 | issue = 41| pages = 26062–26071 | year = 1997 | pmid = 9325344 | doi = 10.1074/jbc.272.41.26062| url = }}</ref><ref name="pmid18055507">{{cite journal | vauthors = Jensen RT, Battey JF, Spindel ER, Benya RV | last-author-amp = yes | title = International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states. | journal = Pharmacol. Rev. | volume = 60 | issue = 1| pages = 1–42 | year = 2007 | pmid = 18055507 | doi = 10.1124/pr.107.07108| url = | pmc = 2517428 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text = Mammalian bombesin-like peptides (see MIM 137260) are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor (MIM 305670), neuromedin B receptor (MIM 162341), and bombesin-like receptor-3 (BRS3) (Ohki-Hamazaki et al., 1997).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: BRS3 bombesin-like receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=680| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist|30em}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F |title=Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. |journal=FEBS Lett. |volume=340 |issue= 3 |pages= 260-4 |year= 1994 |pmid= 8131855 |doi=  }}
*{{cite journal  | vauthors=Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F |title=Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. |journal=FEBS Lett. |volume=340 |issue= 3 |pages= 260–4 |year= 1994 |pmid= 8131855 |doi=10.1016/0014-5793(94)80150-9 }}
*{{cite journal  | author=Fathi Z, Corjay MH, Shapira H, ''et al.'' |title=BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5979-84 |year= 1993 |pmid= 8383682 |doi=  }}
*{{cite journal  | vauthors=Fathi Z, Corjay MH, Shapira H |title=BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5979–84 |year= 1993 |pmid= 8383682 |doi=  |display-authors=etal}}
*{{cite journal  | author=Kane MA, Toi-Scott M, Johnson GL, ''et al.'' |title=Bombesin-like peptide receptors in human bronchial epithelial cells. |journal=Peptides |volume=17 |issue= 1 |pages= 111-8 |year= 1996 |pmid= 8822519 |doi=  }}
*{{cite journal  | vauthors=Kane MA, Toi-Scott M, Johnson GL |title=Bombesin-like peptide receptors in human bronchial epithelial cells. |journal=Peptides |volume=17 |issue= 1 |pages= 111–8 |year= 1996 |pmid= 8822519 |doi=10.1016/0196-9781(95)02088-8 |display-authors=etal}}
*{{cite journal  | author=Ohki-Hamazaki H, Watase K, Yamamoto K, ''et al.'' |title=Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. |journal=Nature |volume=390 |issue= 6656 |pages= 165-9 |year= 1997 |pmid= 9367152 |doi= 10.1038/36568 }}
*{{cite journal  | vauthors=Ohki-Hamazaki H, Watase K, Yamamoto K |title=Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. |journal=Nature |volume=390 |issue= 6656 |pages= 165–9 |year= 1997 |pmid= 9367152 |doi= 10.1038/36568 |display-authors=etal}}
*{{cite journal  | author=Ryan RR, Weber HC, Hou W, ''et al.'' |title=Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13613-24 |year= 1998 |pmid= 9593699 |doi=  }}
*{{cite journal  | vauthors=Ryan RR, Weber HC, Hou W |title=Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13613–24 |year= 1998 |pmid= 9593699 |doi=10.1074/jbc.273.22.13613 |display-authors=etal}}
*{{cite journal  | author=Liu J, Lao ZJ, Zhang J, ''et al.'' |title=Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). |journal=Biochemistry |volume=41 |issue= 28 |pages= 8954-60 |year= 2002 |pmid= 12102638 |doi=  }}
*{{cite journal  | vauthors=Liu J, Lao ZJ, Zhang J |title=Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). |journal=Biochemistry |volume=41 |issue= 28 |pages= 8954–60 |year= 2002 |pmid= 12102638 |doi=10.1021/bi0202777 |display-authors=etal}}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | vauthors=Ross MT, Grafham DV, Coffey AJ |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |display-authors=etal}}
*{{cite journal  | author=Hou X, Wei L, Harada A, Tatamoto K |title=Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. |journal=Lung Cancer |volume=54 |issue= 2 |pages= 143-8 |year= 2007 |pmid= 16979789 |doi= 10.1016/j.lungcan.2006.08.005 }}
*{{cite journal  | vauthors=Hou X, Wei L, Harada A, Tatamoto K |title=Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. |journal=Lung Cancer |volume=54 |issue= 2 |pages= 143–8 |year= 2007 |pmid= 16979789 |doi= 10.1016/j.lungcan.2006.08.005 }}
*{{cite journal  | author=Tan YR, Qin XQ, Xiang Y, ''et al.'' |title=PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. |journal=Biochem. J. |volume=405 |issue= 1 |pages= 131-7 |year= 2007 |pmid= 17355223 |doi= 10.1042/BJ20061754 }}
*{{cite journal  | vauthors=Tan YR, Qin XQ, Xiang Y |title=PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. |journal=Biochem. J. |volume=405 |issue= 1 |pages= 131–7 |year= 2007 |pmid= 17355223 |doi= 10.1042/BJ20061754 | pmc=1925247 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


==External links==
==External links==
* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 IUPHAR GPCR Database - BB<sub>3</sub> receptor]
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 | title = Bombesin Receptors: BB<sub>3</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{MeshName|bombesin+receptor+subtype+3}}
* {{MeshName|bombesin+receptor+subtype+3}}
* {{UCSC gene info|BRS3}}


{{NLM content}}


{{NLM content}}
{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{transmembranereceptor-stub}}

Revision as of 00:55, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (protein)

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Wikidata
View/Edit Human

The bombesin receptor subtype 3 also known as BRS-3 or BB3[1] is a protein which in humans is encoded by the BRS3 gene.[2][3]

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).[3][4]

BB3 is a G protein-coupled receptor.[2] BB3 only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.[2][5][6]

References

  1. ↑ "Bombesin Receptors: BB3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  2. ↑ 2.0 2.1 2.2 Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF (March 1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. PMID 8383682.
  3. ↑ 3.0 3.1 Ohki-Hamazaki H, Wada E, Matsui K, Wada K (July 1997). "Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse". Brain Res. 762 (1–2): 165–72. doi:10.1016/S0006-8993(97)00380-6. PMID 9262170.
  4. ↑ "Entrez Gene: BRS3 bombesin-like receptor 3".
  5. ↑ Mantey SA, Weber HC, Sainz E, Akeson M, Ryan RR, Pradhan TK, Searles RP, Spindel ER, Battey JF, Coy DH & Jensen RT (1997). "Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a uniquepharmacology compared with other mammalian bombesin receptors". J. Biol. Chem. 272 (41): 26062–26071. doi:10.1074/jbc.272.41.26062. PMID 9325344.
  6. ↑ Jensen RT, Battey JF, Spindel ER & Benya RV (2007). "International Union of Pharmacology: The Bombesin Receptors. Nomenclature, distribution, pharmacology, signaling and functions in normal and diseased states". Pharmacol. Rev. 60 (1): 1–42. doi:10.1124/pr.107.07108. PMC 2517428. PMID 18055507.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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