F2RL2: Difference between revisions

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{{Infobox_gene}}
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'''Protease activated receptor 3''' ('''PAR-3''') also known as '''coagulation factor II receptor-like 2''' (F2RL2) and '''thrombin receptor-like 2''', is a [[protein]] that in humans is encoded by the '''F2RL2''' [[gene]].
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coagulation factor II (thrombin) receptor-like 2
| HGNCid = 3539
| Symbol = F2RL2
| AltSymbols =; PAR3
| OMIM = 601919
| ECnumber = 
| Homologene = 36151
| MGIid = 1298208
| GeneAtlas_image1 = PBB_GE_F2RL2_206795_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0015057 |text = thrombin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0009611 |text = response to wounding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2151
    | Hs_Ensembl = ENSG00000164220
    | Hs_RefseqProtein = NP_004092
    | Hs_RefseqmRNA = NM_004101
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 75947064
    | Hs_GenLoc_end = 75954996
    | Hs_Uniprot = O00254
    | Mm_EntrezGene = 14064
    | Mm_Ensembl = ENSMUSG00000021675
    | Mm_RefseqmRNA = NM_010170
    | Mm_RefseqProtein = NP_034300
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 96797656
    | Mm_GenLoc_end = 96803438
    | Mm_Uniprot = Q3UXV3
  }}
}}
'''Coagulation factor II (thrombin) receptor-like 2''', also known as '''F2RL2''' or '''protease activated receptor 3''' ('''PAR3'''), is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of [[G-protein coupled receptor|7-transmembrane receptors]] that couple to [[G protein]]s. F2RL2 is also a member of the [[protease-activated receptor]] family and activated by thrombin. F2RL2 is activated by [[proteolytic]] cleavage of its extracellular [[amino terminus]]. The new amino terminus functions as a tethered [[ligand (biochemistry)|ligand]] and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by [[thrombin]]. It mediates thrombin-triggered [[phosphoinositide]] hydrolysis and is expressed in a variety of tissues.<ref>{{cite web | title = Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2151| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of [[G-protein coupled receptor|7-transmembrane receptors]] that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the [[protease-activated receptor]] family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.<ref>{{cite web | title = Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2151| accessdate = }}</ref>
}}


==See also==
==See also==
Line 58: Line 10:


==References==
==References==
{{reflist|2}}
{{Reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Hollenberg MD, Compton SJ |title=International Union of Pharmacology. XXVIII. Proteinase-activated receptors. |journal=Pharmacol. Rev. |volume=54 |issue= 2 |pages= 203–17 |year= 2002 |pmid= 12037136 |doi=10.1124/pr.54.2.203 }}
| citations =
*{{cite journal  |vauthors=Ishihara H, Connolly AJ, Zeng D |title=Protease-activated receptor 3 is a second thrombin receptor in humans. |journal=Nature |volume=386 |issue= 6624 |pages= 502–6 |year= 1997 |pmid= 9087410 |doi= 10.1038/386502a0 |display-authors=etal}}
*{{cite journal  | author=Hollenberg MD, Compton SJ |title=International Union of Pharmacology. XXVIII. Proteinase-activated receptors. |journal=Pharmacol. Rev. |volume=54 |issue= 2 |pages= 203-17 |year= 2002 |pmid= 12037136 |doi=  }}
*{{cite journal  |vauthors=Schmidt VA, Nierman WC, Maglott DR |title=The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 15061–8 |year= 1998 |pmid= 9614115 |doi=10.1074/jbc.273.24.15061 |display-authors=etal}}
*{{cite journal  | author=Ishihara H, Connolly AJ, Zeng D, ''et al.'' |title=Protease-activated receptor 3 is a second thrombin receptor in humans. |journal=Nature |volume=386 |issue= 6624 |pages= 502-6 |year= 1997 |pmid= 9087410 |doi= 10.1038/386502a0 }}
*{{cite journal  |vauthors=Xu WF, Andersen H, Whitmore TE |title=Cloning and characterization of human protease-activated receptor 4 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6642–6 |year= 1998 |pmid= 9618465 |doi=10.1073/pnas.95.12.6642 | pmc=22580  |display-authors=etal}}
*{{cite journal  | author=Schmidt VA, Nierman WC, Maglott DR, ''et al.'' |title=The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 15061-8 |year= 1998 |pmid= 9614115 |doi=  }}
*{{cite journal  |vauthors=Guyonnet Dupérat V, Jacquelin B, Boisseau P |title=Protease-activated receptor genes are clustered on 5q13 |journal=Blood |volume=92 |issue= 1 |pages= 25–31 |year= 1998 |pmid= 9639495 |doi=  |display-authors=etal}}
*{{cite journal  | author=Xu WF, Andersen H, Whitmore TE, ''et al.'' |title=Cloning and characterization of human protease-activated receptor 4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6642-6 |year= 1998 |pmid= 9618465 |doi=  }}
*{{cite journal  |vauthors=Kahn ML, Zheng YW, Huang W |title=A dual thrombin receptor system for platelet activation |journal=Nature |volume=394 |issue= 6694 |pages= 690–4 |year= 1998 |pmid= 9716134 |doi= 10.1038/29325 |display-authors=etal}}
*{{cite journal  | author=Guyonnet Dupérat V, Jacquelin B, Boisseau P, ''et al.'' |title=Protease-activated receptor genes are clustered on 5q13. |journal=Blood |volume=92 |issue= 1 |pages= 25-31 |year= 1998 |pmid= 9639495 |doi=  }}
*{{cite journal  |vauthors=Kahn ML, Hammes SR, Botka C, Coughlin SR |title=Gene and locus structure and chromosomal localization of the protease-activated receptor gene family |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23290–6 |year= 1998 |pmid= 9722561 |doi=10.1074/jbc.273.36.23290 }}
*{{cite journal  | author=Kahn ML, Zheng YW, Huang W, ''et al.'' |title=A dual thrombin receptor system for platelet activation. |journal=Nature |volume=394 |issue= 6694 |pages= 690-4 |year= 1998 |pmid= 9716134 |doi= 10.1038/29325 }}
*{{cite journal  |vauthors=Kahn ML, Nakanishi-Matsui M, Shapiro MJ |title=Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin |journal=J. Clin. Invest. |volume=103 |issue= 6 |pages= 879–87 |year= 1999 |pmid= 10079109 |doi=10.1172/JCI6042 | pmc=408153  |display-authors=etal}}
*{{cite journal  | author=Kahn ML, Hammes SR, Botka C, Coughlin SR |title=Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. |journal=J. Biol. Chem. |volume=273 |issue= 36 |pages= 23290-6 |year= 1998 |pmid= 9722561 |doi=  }}
*{{cite journal  |vauthors=Hauck RW, Schulz C, Schömig A |title=alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors |journal=Am. J. Physiol. |volume=277 |issue= 1 Pt 1 |pages= L22–9 |year= 1999 |pmid= 10409227 |doi=  |display-authors=etal}}
*{{cite journal  | author=Kahn ML, Nakanishi-Matsui M, Shapiro MJ, ''et al.'' |title=Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. |journal=J. Clin. Invest. |volume=103 |issue= 6 |pages= 879-87 |year= 1999 |pmid= 10079109 |doi=  }}
*{{cite journal  |vauthors=Nakanishi-Matsui M, Zheng YW, Sulciner DJ |title=PAR3 is a cofactor for PAR4 activation by thrombin |journal=Nature |volume=404 |issue= 6778 |pages= 609–13 |year= 2000 |pmid= 10766244 |doi= 10.1038/35007085 |display-authors=etal}}
*{{cite journal  | author=Hauck RW, Schulz C, Schömig A, ''et al.'' |title=alpha-Thrombin stimulates contraction of human bronchial rings by activation of protease-activated receptors. |journal=Am. J. Physiol. |volume=277 |issue= 1 Pt 1 |pages= L22-9 |year= 1999 |pmid= 10409227 |doi=  }}
*{{cite journal  |vauthors=O'Brien PJ, Prevost N, Molino M |title=Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1 |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13502–9 |year= 2000 |pmid= 10788464 |doi=10.1074/jbc.275.18.13502  |display-authors=etal}}
*{{cite journal  | author=Nakanishi-Matsui M, Zheng YW, Sulciner DJ, ''et al.'' |title=PAR3 is a cofactor for PAR4 activation by thrombin. |journal=Nature |volume=404 |issue= 6778 |pages= 609-13 |year= 2000 |pmid= 10766244 |doi= 10.1038/35007085 }}
*{{cite journal  |vauthors=Cumashi A, Ansuini H, Celli N |title=Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets |journal=Thromb. Haemost. |volume=85 |issue= 3 |pages= 533–8 |year= 2001 |pmid= 11307827 |doi=  |display-authors=etal}}
*{{cite journal  | author=O'Brien PJ, Prevost N, Molino M, ''et al.'' |title=Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1. |journal=J. Biol. Chem. |volume=275 |issue= 18 |pages= 13502-9 |year= 2000 |pmid= 10788464 |doi= }}
*{{cite journal  |vauthors=Sambrano GR, Weiss EJ, Zheng YW |title=Role of thrombin signalling in platelets in haemostasis and thrombosis |journal=Nature |volume=413 |issue= 6851 |pages= 74–8 |year= 2001 |pmid= 11544528 |doi= 10.1038/35092573 |display-authors=etal}}
*{{cite journal  | author=Cumashi A, Ansuini H, Celli N, ''et al.'' |title=Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets. |journal=Thromb. Haemost. |volume=85 |issue= 3 |pages= 533-8 |year= 2001 |pmid= 11307827 |doi=  }}
*{{cite journal  |vauthors=Miike S, McWilliam AS, Kita H |title=Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2 |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6615–22 |year= 2002 |pmid= 11714832 |doi=  10.4049/jimmunol.167.11.6615}}
*{{cite journal  | author=Sambrano GR, Weiss EJ, Zheng YW, ''et al.'' |title=Role of thrombin signalling in platelets in haemostasis and thrombosis. |journal=Nature |volume=413 |issue= 6851 |pages= 74-8 |year= 2001 |pmid= 11544528 |doi= 10.1038/35092573 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Miike S, McWilliam AS, Kita H |title=Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6615-22 |year= 2002 |pmid= 11714832 |doi=  }}
*{{cite journal  |vauthors=Even-Ram SC, Grisaru-Granovsky S, Pruss D |title=The pattern of expression of protease-activated receptors (PARs) during early trophoblast development |journal=J. Pathol. |volume=200 |issue= 1 |pages= 47–52 |year= 2003 |pmid= 12692840 |doi= 10.1002/path.1338 |display-authors=etal}}
*{{cite journal  | author=Uehara A, Sugawara S, Muramoto K, Takada H |title=Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2. |journal=J. Immunol. |volume=169 |issue= 8 |pages= 4594-603 |year= 2002 |pmid= 12370398 |doi=  }}
*{{cite journal  | author=Owen WG |title=PAR-3 is a low-affinity substrate, high affinity effector of thrombin |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 166–8 |year= 2003 |pmid= 12732212 |doi=10.1016/S0006-291X(03)00732-0  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Tanaka N, Morita T, Nezu A |title=Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1) |journal=Life Sci. |volume=73 |issue= 3 |pages= 301–10 |year= 2003 |pmid= 12757837 |doi=10.1016/S0024-3205(03)00269-8 |display-authors=etal}}
*{{cite journal  | author=Even-Ram SC, Grisaru-Granovsky S, Pruss D, ''et al.'' |title=The pattern of expression of protease-activated receptors (PARs) during early trophoblast development. |journal=J. Pathol. |volume=200 |issue= 1 |pages= 47-52 |year= 2003 |pmid= 12692840 |doi= 10.1002/path.1338 }}
*{{cite journal  | author=Owen WG |title=PAR-3 is a low-affinity substrate, high affinity effector of thrombin. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 1 |pages= 166-8 |year= 2003 |pmid= 12732212 |doi=  }}
*{{cite journal  | author=Tanaka N, Morita T, Nezu A, ''et al.'' |title=Thrombin-induced Ca2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1). |journal=Life Sci. |volume=73 |issue= 3 |pages= 301-10 |year= 2003 |pmid= 12757837 |doi=  }}
}}
{{refend}}
{{refend}}


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Revision as of 04:30, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a protein that in humans is encoded by the F2RL2 gene.

Function

Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to G proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.[1]

See also

References

  1. ↑ "Entrez Gene: F2RL2 coagulation factor II (thrombin) receptor-like 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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