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{{Infobox_gene}}
 
'''Frizzled-2''' is a [[protein]] that in humans is encoded by the ''FZD2'' [[gene]].<ref name="pmid7558010">{{cite journal |vauthors=Zhao Z, Lee CC, Baldini A, Caskey CT | title = A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1 | journal = Genomics | volume = 27 | issue = 2 | pages = 370–3 |date=Nov 1995 | pmid = 7558010 | pmc =  | doi = 10.1006/geno.1995.1060 }}</ref><ref name="pmid9813155">{{cite journal |vauthors=Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 |date=Dec 1998 | pmid = 9813155 | pmc =  | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2535| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Frizzled homolog 2 (Drosophila)
| HGNCid = 4040
| Symbol = FZD2
| AltSymbols =;
| OMIM = 600667
| ECnumber =
| Homologene = 20377
| MGIid = 1888513
  | GeneAtlas_image1 = PBB_GE_FZD2_210220_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007164 |text = establishment of tissue polarity}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2535
    | Hs_Ensembl = ENSG00000180340
    | Hs_RefseqProtein = NP_001457
    | Hs_RefseqmRNA = NM_001466
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 39990353
    | Hs_GenLoc_end = 39992382
    | Hs_Uniprot = Q14332
    | Mm_EntrezGene = 57265
    | Mm_Ensembl = ENSMUSG00000050288
    | Mm_RefseqmRNA = NM_020510
    | Mm_RefseqProtein = NP_065256
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 102420623
    | Mm_GenLoc_end = 102424144
    | Mm_Uniprot = Q923Z9
  }}
}}
'''Frizzled homolog 2 (Drosophila)''', also known as '''FZD2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2535| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.<ref name="entrez">{{cite web | title = Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2535| accessdate = }}</ref>
| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.<ref name="entrez">{{cite web | title = Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2535| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3060 | title = Frizzled Receptors: FZD<sub>2</sub> | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zhao Z, Lee CC, Baldini A, Caskey CT |title=A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. |journal=Genomics |volume=27 |issue= 2 |pages= 370-3 |year= 1995 |pmid= 7558010 |doi= 10.1006/geno.1995.1060 }}
*{{cite journal  |vauthors=Wang Y, Macke JP, Abella BS |title=A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4468–76 |year= 1996 |pmid= 8626800 |doi=10.1074/jbc.271.8.4468 |display-authors=etal}}
*{{cite journal  | author=Wang Y, Macke JP, Abella BS, ''et al.'' |title=A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4468-76 |year= 1996 |pmid= 8626800 |doi=  }}
*{{cite journal  |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770  | pmc=21233 |display-authors=etal}}
*{{cite journal  | author=Finch PW, He X, Kelley MJ, ''et al.'' |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770-5 |year= 1997 |pmid= 9192640 |doi=  }}
*{{cite journal  |vauthors=Tanaka S, Akiyoshi T, Mori M |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164–9 |year= 1998 |pmid= 9707618 |doi=10.1073/pnas.95.17.10164  | pmc=21479  |display-authors=etal}}
*{{cite journal  | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164-9 |year= 1998 |pmid= 9707618 |doi= }}
*{{cite journal  |vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4 }}
*{{cite journal  | author=Sagara N, Toda G, Hirai M, ''et al.'' |title=Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. |journal=Biochem. Biophys. Res. Commun. |volume=252 |issue= 1 |pages= 117-22 |year= 1998 |pmid= 9813155 |doi= 10.1006/bbrc.1998.9607 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185-9 |year= 2002 |pmid= 12067714 |doi=  }}
*{{cite journal  |vauthors=Oishi I, Suzuki H, Onishi N |title=The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway |journal=Genes Cells |volume=8 |issue= 7 |pages= 645–54 |year= 2004 |pmid= 12839624 |doi=10.1046/j.1365-2443.2003.00662.x |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |display-authors=etal}}
*{{cite journal  | author=Oishi I, Suzuki H, Onishi N, ''et al.'' |title=The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. |journal=Genes Cells |volume=8 |issue= 7 |pages= 645-54 |year= 2004 |pmid= 12839624 |doi=  }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors|g4}}
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[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]


{{WH}}
 
{{WS}}
{{transmembranereceptor-stub}}

Revision as of 05:00, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.[3]

See also

References

  1. ↑ Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics. 27 (2): 370–3. doi:10.1006/geno.1995.1060. PMID 7558010.
  2. ↑ Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
  3. ↑ 3.0 3.1 "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)".

External links

  • "Frizzled Receptors: FZD2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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