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{{Infobox_gene}}
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'''Probable G-protein coupled receptor 110''' is a [[protein]] that in humans is encoded by the ''GPR110'' [[gene]].<ref name="pmid12435584">{{cite journal |vauthors=Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Lett | volume = 531 | issue = 3 | pages = 407–14 |date=Nov 2002 | pmid = 12435584 | pmc =  | doi =10.1016/S0014-5793(02)03574-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR110 G protein-coupled receptor 110| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=266977| accessdate = }}</ref> This gene encodes a member of the [[adhesion-GPCRs|adhesion-GPCR]] receptor family.<ref name="isbn1-4419-7912-3">{{cite book |vauthors=Stacey M, Yona S | title = Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 1-4419-7912-3 }}</ref> Family members are characterized by an extended extracellular region with a variable number of [[N-terminal]] protein modules coupled to a [[G protein-coupled receptor|TM7]] region via a domain known as the GPCR-Autoproteolysis INducing [[GAIN domain|(GAIN)]] domain.<ref name="pmid22333914">{{cite journal |vauthors=Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = EMBO J. | volume = 31 | issue = 6 | pages = 1364–78 |date=March 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }}</ref>
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==References==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = G protein-coupled receptor 110
| HGNCid = 18990
| Symbol = GPR110
| AltSymbols =; FLJ22684; FLJ30646; KPG_012; MGC125952; PGR19; hGPCR36
| OMIM = 
| ECnumber = 
| Homologene = 15875
| MGIid = 1924846
| GeneAtlas_image1 = PBB_GE_GPR110_220907_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 266977
    | Hs_Ensembl = ENSG00000153292
    | Hs_RefseqProtein = NP_079324
    | Hs_RefseqmRNA = NM_025048
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 47075076
    | Hs_GenLoc_end = 47118041
    | Hs_Uniprot = Q5T601
    | Mm_EntrezGene = 77596
    | Mm_Ensembl = ENSMUSG00000041293
    | Mm_RefseqmRNA = NM_133776
    | Mm_RefseqProtein = NP_598537
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 42735599
    | Mm_GenLoc_end = 42789390
    | Mm_Uniprot = Q8BWD9
  }}
}}
'''G protein-coupled receptor 110''', also known as '''GPR110''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPR110 G protein-coupled receptor 110| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=266977| accessdate = }}</ref>


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| summary_text =
}}
==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
| citations =
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | author=Takeda S |title=Identification of G protein-coupled receptor genes from the human genome sequence |journal=FEBS Lett. |volume=520 |issue= 1–3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=10.1016/S0014-5793(02)02775-8 |name-list-format=vanc| author2=Kadowaki S  | author3=Haga T  | display-authors=3 | last4=Takaesu  | first4=H  | last5=Mitaku  | first5=S }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi= }}
*{{cite journal  | author=Vassilatis DK |title=The G protein-coupled receptor repertoires of human and mouse |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4903–8 |year= 2003 |pmid= 12679517 |doi= 10.1073/pnas.0230374100 | pmc=153653  |name-list-format=vanc| author2=Hohmann JG  | author3=Zeng H  | display-authors=3  | last4=Li  | first4=F  | last5=Ranchalis  | first5=JE  | last6=Mortrud  | first6=MT  | last7=Brown  | first7=A  | last8=Rodriguez  | first8=SS  | last9=Weller  | first9=JR }}
*{{cite journal | author=Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB |title=Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. |journal=FEBS Lett. |volume=531 |issue= 3 |pages= 407-14 |year= 2002 |pmid= 12435584 |doi=  }}
*{{cite journal  | author=Mungall AJ |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055  |name-list-format=vanc| author2=Palmer SA  | author3=Sims SK  | display-authors=3  | last4=Edwards  | first4=C. A. | last5=Ashurst  | first5=J. L. | last6=Wilming  | first6=L.  | last7=Jones  | first7=M. C.  | last8=Horton  | first8=R.  | last9=Hunt | first9=S. E. }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Vassilatis DK, Hohmann JG, Zeng H, ''et al.'' |title=The G protein-coupled receptor repertoires of human and mouse. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4903-8 |year= 2003 |pmid= 12679517 |doi= 10.1073/pnas.0230374100 }}
*{{cite journal  | author=Bjarnadóttir TK |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 |name-list-format=vanc| author2=Fredriksson R  | author3=Höglund PJ  | display-authors=3  | last4=Gloriam  | first4=David E.  | last5=Lagerström  | first5=Malin C.  | last6=Schiöth  | first6=Helgi B. }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Fredriksson R, Höglund PJ, Gloriam DE, ''et al.'' |title=Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. |journal=FEBS Lett. |volume=554 |issue= 3 |pages= 381-8 |year= 2003 |pmid= 14623098 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23-33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Revision as of 08:57, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene.[1][2] This gene encodes a member of the adhesion-GPCR receptor family.[3] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[4]

References

  1. ↑ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584.
  2. ↑ "Entrez Gene: GPR110 G protein-coupled receptor 110".
  3. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
  4. ↑ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

Further reading


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